Detection of e Antigen and Antibody: Correlations With Hepatitis B Surface and Hepatitis B Core Antigens, Liver Disease, and Outcome in Hepatitis B Infections

Trépo, Christian; Magnius, Lars O.; Schaefer, Robert A.; Prince, Alfred M.

doi:10.1016/s0016-5085(76)80364-2

Cited by 107 publications

(24 citation statements)

References 15 publications

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“…Other etiologies for inflammation, e.g., recent alcohol consumption, HCV and hepatitis delta virus infection, were excluded. There was expression of HBsAg in all cases, and there was a significant correlation between expression of cytoplasmic HBcAg staining with interface hepatitis and lobular inflammation 21–23. Although detectable HBV DNA levels were not present in many cases, it is important to emphasize that the less sensitive liquid hybridization assay for HBV DNA previously employed for clinical indications was used rather than the more sensitive polymerase chain reaction assay that is currently available.…”

Section: Discussionmentioning

confidence: 99%

“…HBeAg and HBV DNA levels greater than 5 pg/mL are also useful indicators of inflammation in chronic hepatitis 23. The presence of HBeAg is associated with elevated aminotransferase levels and active inflammation, and HBeAg to anti‐HBe seroconversion is usually accompanied by normalization of aminotransferase levels and decreased inflammation 6, 13, 14, 22. Likewise, detectable serum HBV DNA is associated with lobular inflammation, and its persistence predicts histologic progression 2, 3, 10, 28, 29…”

Section: Discussionmentioning

confidence: 99%

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Histopathology and clinical correlates of end-stage hepatitis B cirrhosis: A possible mechanism to explain the response to antiviral therapy

Sigal

Ala²,

Ivanov³

et al. 2004

Liver Transpl

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In chronic liver disease associated with histological necroinflammation, clinical severity is frequently greater in those with higher grades of activity. Conventional wisdom assumes that necroinflammation is mild or absent in patients with end-stage hepatitis B virus (HBV) cirrhosis due to the frequent presence of mildly elevated aminotransferase levels, the absence of hepatitis B e antigen (HBeAg), and low or undetectable HBV deoxyribonucleic acid (DNA) levels. However, a histopathologic analysis of such patients has not been undertaken. The aims of this study were 1) to assess severity and histological features of inflammation, 2) to correlate the severity of inflammation with biochemical and virologic parameters, and 3) to define the relationship between inflammation and clinical severity in explanted livers from patients undergoing liver transplantation for HBV cirrhosis. Characteristics of 34 consecutive patients undergoing liver transplantation for HBV cirrhosis were correlated with inflammation and immunohistological findings in the explanted livers. High-grade inflammation (grades 3 and 4) was found in many cases (47.1% interface hepatitis; 14.8% lobular inflammation; and 20.6% portal inflammation). The presence of positive cytoplasmic staining for hepatitis B core antigen (HBcAg) was associated with grade 3 or 4 interface hepatitis (P ‫؍‬ .046) and lobular hepatitis (P ‫؍‬ .005). There was no correlation between inflammatory activity and age, Asian ethnicity, aminotransferase levels, total bilirubin levels, HBeAg seropositivity, and detect-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathology and clinical correlates of end-stage hepatitis B cirrhosis: A possible mechanism to explain the response to antiviral therapy

Sigal

Ala²,

Ivanov³

et al. 2004

Liver Transpl

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“…HBe antigen has also been promoted as a useful prognostic pointer (Trepo et al, 1976). This antigen was found in the sera of two of eight HBsAg positive patients from whom blood was available; both progressed to chronic active liver disease.…”

Section: Discussionmentioning

confidence: 99%

Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up.

Chadwick¹,

Galizzi²,

Heathcote³

et al. 1979

Gut

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SUMMARY Twenty-six untreated patients with chronic persistent hepatitis were followed prospectively for one to 17 years (mean 5 6 years). The patients developed no clinical features of chronic liver disease. Raised serum transaminase levels were usually, but not consistently, the only biochemical abnormality; gamma globulin values were normal. Serum markers of past or present hepatitis B infection were found initially in 14 patients: another two developed markers during their follow-up. Nine patients progressed to a mild or moderate chronic active hepatitis as shown by serial needle liver biopsies but there was no evidence of cirrhosis. This progression was not associated with any clinical or biochemical deterioration. Seven of these patients had presented with insidious symptoms, seven had serum markers of hepatitis B infection, and the four who were HBsAg positive had relatively lower serum HBsAg concentrations than did those patients who continued with chronic persistent hepatitis.

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“…However, the occurrence of HBsAg, HBcAg, and HBeAg in the cytoplasm and nuclei of the hepatocytes, as detected by immunohistological methods, indicated an ongoing infection with HBV. Trepo et al 6 reported that the presence of HBeAg was correlated with a high titer of HBsAg, and with immunofluorescent detection of HBcAg in the nuclei of hepatocytes. The present patient, who lacked symptoms of hepatitis in The report in 1970 by Gocke et al 7 of four patients with HB-associated PAN was described as "the first recognition in man of a systemic vasculitis mediated by an immunologic reaction to a virus."…”

Section: Discussionmentioning

confidence: 99%

An autopsy case of hepatitis B (HB) antigen-positive polyarteritis nodosa, with reference to immunopathological studies of vascular lesions

Nonogaki

Aoki

Yoshikawa

et al. 2000

Modern Rheumatology

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An autopsy case of an 11-year-old boy with polyarteritis nodosa is described in which the onset of the disease was associated with the presence of hepatitis B (HB) antigens (Ag) in the cytoplasm and nuclei of hepatocytes as detected by immunohistological methods. Deposits of HBsAg, HBeAg, IgG, IgM, C3, and C1q were demonstrated in systemic vascular lesions. It is considered that the arteritis was due to deposition in the arteries of immune complexes formed by HBAg and HB antibodies.

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Detection of e Antigen and Antibody: Correlations With Hepatitis B Surface and Hepatitis B Core Antigens, Liver Disease, and Outcome in Hepatitis B Infections

Cited by 107 publications

References 15 publications

Histopathology and clinical correlates of end-stage hepatitis B cirrhosis: A possible mechanism to explain the response to antiviral therapy

Histopathology and clinical correlates of end-stage hepatitis B cirrhosis: A possible mechanism to explain the response to antiviral therapy

Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up.

An autopsy case of hepatitis B (HB) antigen-positive polyarteritis nodosa, with reference to immunopathological studies of vascular lesions

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