Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up.

Chadwick, R. G.; Galizzi, J; Heathcote, Jenny; Lyssiotis, T; Cohen, B. J.; Scheuer, Peter J.; Sherlock, Sheila

doi:10.1136/gut.20.5.372

Cited by 36 publications

(7 citation statements)

References 15 publications

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“…The prognosis for CLH is, therefore, considered to be as good as that of CPH (21). The histological follow-up of our 32 patients confirms that evidence of progression could not be found during 4% years.…”

Section: 0%)supporting

confidence: 72%

“…Based on a careful follow-up study of five patients, Wilkinson et al (10) suggested that CLH would not progress to liver cirrhosis in a period as long as 8 years. The prognosis for CLH is, therefore, considered to be as good as that of CPH (21). The histological follow-up of our 32 patients confirms that evidence of progression could not be found during 4% years.…”

Section: Follow-upsupporting

confidence: 65%

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Chronic Lobular Hepatitis: A Clinicopathological and Prognostic Study

et al. 1982

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A series of 80 patients with chronic lobular hepatitis (CLH) was reviewed clinically and histologically to demonstrate etiology, clinical presentation, course, and prognosis of this disorder. Data from our study indicate that CLH in Taiwan is a disease of viral origin, mostly hepatitis B (67.5%) and some non-A, non-B. It occurs predominantly in young males (81.3%); frequently commences as acute viral hepatitis (57.5%); and has clinical and laboratory features similar to convalescent viral hepatitis or even indistinguishable from full-blown acute viral hepatitis. Clinical and histological follow-up study indicate that CLH may extend for several years with remissions and relapses. No evidence of progression to cirrhosis was observed at least in a 4%-year period of follow-up. It is concluded that CLH is a persistent but nonprogressive disease although the number of non-A, non-B CLH is too small to ascertain its nonprogressive course. The prognosis is generally good, and no specific therapy is required.Chronic lobular hepatitis (CLH) was first proposed and described by Popper and Schaffner (1) as "acute hepatitis" lasting for longer than 3 months. Although the term CLH was not accepted by the International Association for the Study of the Liver (IASL) (2) it has repeatedly appeared in the literature not only by Popper and Schaffner (3, 4) but also by European investigators (5-8). The most recent report of an international group also adopted CLH as one form of chronic hepatitis (9).However, only a few clinical studies on small series of CLH have been documented since the term was proposed (10-12). On the other hand, chronic hepatitis has been defined by the IASL as hepatitis with a minimum duration of 6 months (2). The original definition of CLH by Popper and Schaffner (1) should be modified in time scale. It is, therefore, relevant at this time to further investigate this type of chronic hepatitis by a large series of patients. MATERIALS AND METHODSThe patients were selected by extensive clinical and pathological review from a consecutive series of patients who had been studied by liver biopsy in our Liver Unit

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Section: 0%)supporting

confidence: 72%

Section: Follow-upsupporting

confidence: 65%

Chronic Lobular Hepatitis: A Clinicopathological and Prognostic Study

et al. 1982

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“…The diagnosis of chronic persistent hepatitis (CPH) is based on histological, biochemical, and clinical findings (1,2). Generally, the prognosis of CPH is regarded as good (2)(3)(4)(5). There are data, however, suggesting that histological changes compatible with CPH might not always identify a homogeneous disease entirety.…”

mentioning

confidence: 99%

“…There are data, however, suggesting that histological changes compatible with CPH might not always identify a homogeneous disease entirety. Several authors (2,4,6) have found that in at least some of the patients, the disease progresses to chronic active hepatitis (CAH) or cirrhosis. On the basis of the findings in a single patient, it has been suggested that the presence of hepatitis B e antigen (HBeAg) in patients with CPH might indicate a poor prognosis (7).…”

mentioning

confidence: 99%

Chronic Persistent Hepatitis: Serological Classification and Meaning of the Hepatitis B E System

et al. 1982

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In order to evaluate the prognostic implications of the hepatitis B e system in patients with chronic persistent hepatitis (CPH), 53 consecutive patients were studied. Fourteen of 16 patients with HBsAg and HBeAg were followed from 12 to 120 months (mean, 38 months). Eleven of the 14 patients were persistently HBeAg positive and five of these developed chronic active hepatitis (CAH) or cirrhosis. A further nine patients were HBsAg positive but HBeAg negative at time of CPH diagnosis (mean follow-up, 47 months). One of these nine patients developed CAH during follow-up. The remaining 28 patients were all HBsAg negative, and only 2 of the 28 patients progressed to CAH or cirrhosis during the time of follow-up (mean, 43 months). It is concluded that the persistence of HBeAg in patients with CPH indicates a serious prognosis with a frequent transition to CAH or cirrhosis.

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“…Some patients develop the appearances of chronic lobular hepatitis (Dudley et al 1972) or chronic active hepatitis without cirrhosis (Chadwick et al 1979). One patient is reported to have developed cirrhosis seven months after an initial biopsy showed the appearances of CPH (Dietrichson 1975).…”

Section: Aetiological Agentsmentioning

confidence: 99%

Chronic Hepatitis: A Review

Bradbear

1985

J R Soc Med

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Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up.

Cited by 36 publications

References 15 publications

Chronic Lobular Hepatitis: A Clinicopathological and Prognostic Study

Chronic Lobular Hepatitis: A Clinicopathological and Prognostic Study

Chronic Persistent Hepatitis: Serological Classification and Meaning of the Hepatitis B E System

Chronic Hepatitis: A Review

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