Detection of Ductal Carcinoma in Situ with Mammography, Breast Specific Gamma Imaging, and Magnetic Resonance Imaging: A Comparative Study

Brem, Rachel F.; Fishman, Michael; Rapelyea, Jocelyn A.

doi:10.1016/j.acra.2007.04.004

Cited by 78 publications

(52 citation statements)

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“…Preliminary studies have demonstrated that BSGC scintigraphy may also be useful in the detection of DCIS, with sensitivity similar to or even higher than that of mammography, in comparative studies (10,11). In a series of 13 patients with 13 surgically proven DCISs, scintigraphy and mammography showed the same sensitivity (92.3%), with 1 DCIS evidenced only at scintigraphy and 1 DCIS ascertained only at mammography (10).…”

Section: Discussionmentioning

confidence: 68%

“…In a series of 13 patients with 13 surgically proven DCISs, scintigraphy and mammography showed the same sensitivity (92.3%), with 1 DCIS evidenced only at scintigraphy and 1 DCIS ascertained only at mammography (10). In another series of 20 patients with 22 biopsy-proven DCISs, 91% of lesions were detected by BSGC scintigraphy and 82% by mammography, with 2 DCISs evidenced only at BSGC (11). In the present study performed on a consecutive series of 33 patients with pure DCIS, we further evaluated the usefulness of BSGC scintigraphy in the detection of DCIS and correlated the scintigraphic features with mammographic findings and histopathologic subtype.…”

Section: Discussionmentioning

confidence: 85%

“…Preliminary studies have demonstrated that BSGC scintigraphy may also be useful in the detection of DCIS, with sensitivity ranging from 87.5% to 92.3% (10)(11)(12).…”

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confidence: 99%

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Breast Scintigraphy with Breast-Specific γ-Camera in the Detection of Ductal Carcinoma In Situ: A Correlation with Mammography and Histologic Subtype

et al. 2012

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Ductal carcinoma in situ (DCIS) is a subtype of breast cancer encountered increasingly in clinical practice because of the widespread use of screening mammography. In the present study, we evaluated the usefulness of breast-specific g-camera (BSGC) scintigraphy in DCIS identification, describing the scintigraphic findings and their correlation with mammography and histologic subtype. Methods: Thirty-three women, aged 41-81 y, with surgically proven DCIS were retrospectively reviewed. Before surgery, all patients underwent breast scintigraphy using a high-resolution semiconductor-based BSGC, starting 10 min after intravenous injection of 740 MBq of 99m Tc-tetrofosmin. All patients had previously undergone mammography. A definitive histologic diagnosis was obtained in all cases after scintigraphy, and the scintigraphic findings were correlated with mammography and histologic subtype. Results: Mammography was positive in 30 of 33 patients (sensitivity, 90.9%), showing calcifications in 22 of 30 (73.3%), masses in 3 of 30 (10%), and masses plus calcifications in the remaining 5 of 30 (16.7%). Scintigraphy was positive in 31 of 33 patients (sensitivity, 93.9%), showing patchy irregular uptake in patients with calcifications and focal uptake in masses; sensitivity was higher in low-to intermediate-grade DCIS than in intermediate/high-and high-grade DCIS (100% vs. 91.3%), but the difference was not statistically significant. Two comedo-type DCIS (one 20-mm intermediate/high-grade and one 15-mm high-grade) with heterogeneously or highly dense breasts at mammography and one papillary low/intermediate-grade DCIS associated with Paget disease were true positive only at scintigraphy. Moreover, scintigraphy better assessed disease extent than did mammography in 5 additional patients. Two comedo-type DCIS (one 6-mm intermediate/highgrade and one 15-mm high-grade) were true positive only at mammography. The difference in sensitivity between scintigraphy and mammography was not statistically significant. The combined use of mammography and scintigraphy achieved 100% sensitivity. Conclusion: BSGC scintigraphy proved to be a highly sensitive diagnostic tool in the detection of DCIS, irrespective of histologic subtype, and with a scintigraphic pattern of uptake that correlated well with mammography findings. In our series, BSGC scintigraphy demonstrated a slightly higher sensitivity than mammography and a better assessment of local disease extent. Thus, BSGC scintigraphy should represent a useful adjunctive tool in breast cancer diagnosis.Key Words: DCIS; breast-specific g-camera scintigraphy; mammography Duct al carcinoma in situ (DCIS) of the breast is a noninvasive subtype of primary breast cancer characterized by a malignant proliferation of ductal epithelium with no histologic evidence of invasion through the ductal basement membrane (1). The mortality associated with a pure DCIS without invasion is thus extremely low, generally lower than 1%-2% (2).However, different behaviors have been observed after the initial treatment; ...

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 85%

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Breast Scintigraphy with Breast-Specific γ-Camera in the Detection of Ductal Carcinoma In Situ: A Correlation with Mammography and Histologic Subtype

et al. 2012

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“…[12][13][14] MRI is capable of detecting small lesions undetected by mammography. 15 However it has many false positives 16,17 and is prohibitively expensive. 18 Besides women under 40, 43% of women 40-74 yrs old 19 and a) Author to whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Development of array piezoelectric fingers towards in vivo breast tumor detection

Chung

Brooks

et al. 2016

Review of Scientific Instruments

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We have investigated the development of a handheld 4 × 1 piezoelectric finger (PEF) array breast tumor detector system towards in vivo patient testing, particularly, on how the duration of the DC applied voltage, the depression depth of the handheld unit, and breast density affect the PEF detection sensitivity on 40 patients. The tests were blinded and carried out in four phases: with DC voltage durations 5, 3, 2, to 0.8 s corresponding to scanning a quadrant, a half, a whole breast, and both breasts within 30 min, respectively. The results showed that PEF detection sensitivity was unaffected by shortening the applied voltage duration from 5 to 0.8 s nor was it affected by increasing the depression depth from 2 to 6 mm. Over the 40 patients, PEF detected 46 of the 48 lesions (46/48)-with the smallest lesion detected being 5 mm in size. Of 28 patients (some have more than one lesion) with mammography records, PEF detected 31/33 of all lesions (94%) and 14/15 of malignant lesions (93%), while mammography detected 30/33 of all lesions (91%) and 12/15 of malignant lesions (80%), indicating that PEF could detect malignant lesions not detectable by mammography without significantly increasing false positives. PEF's detection sensitivity is also shown to be independent of breast density, suggesting that PEF could be a potential tool for detecting breast cancer in young women and women with dense breasts. Published by AIP Publishing. [http://dx

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“…Thus, the breast-specific g-camera makes possible the acquisition of images with positions comparable to mammography. There are multiple references to the excellent clinical results obtained with this technologic advance (5)(6)(7)(8)(9).…”

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confidence: 99%

The SNM Practice Guideline on Breast Scintigraphy

Goldsmith¹

2010

J Nucl Med

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Detection of Ductal Carcinoma in Situ with Mammography, Breast Specific Gamma Imaging, and Magnetic Resonance Imaging: A Comparative Study

Cited by 78 publications

References 9 publications

Breast Scintigraphy with Breast-Specific γ-Camera in the Detection of Ductal Carcinoma In Situ: A Correlation with Mammography and Histologic Subtype

Breast Scintigraphy with Breast-Specific γ-Camera in the Detection of Ductal Carcinoma In Situ: A Correlation with Mammography and Histologic Subtype

Development of array piezoelectric fingers towards in vivo breast tumor detection

The SNM Practice Guideline on Breast Scintigraphy

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