The SNM Practice Guideline on Breast Scintigraphy

Goldsmith, Stanley J.

doi:10.2967/jnumed.110.084400

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…The BSGI data were classified into 5 categories according to the 2010 guidelines of the Breast Imaging Reporting and Data System (BIRADS) of the Society and Nuclear Medicine and Molecular Imaging. [ 10 ] Scores of 1, 2, and 3were classified as negative, and scores of 4 and 5were defined as positive. The scores were visually assessed by consensus between the 2 readers.…”

Section: Methodsmentioning

confidence: 99%

Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer

Lee¹,

Chung²,

Shin

et al. 2018

Medicine

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Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and 18F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes.A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUVmax) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes.In all tumors, there was a moderate positive correlation between TBR and SUVmax (r = 0.520, P < .001). Both TBR and SUVmax were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67.There is a moderate degree of association between TBR of sestamibi and SUVmax of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUVmax were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.

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Section: Methodsmentioning

confidence: 99%

Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer

Lee¹,

Chung²,

Shin

et al. 2018

Medicine

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“…www.onk.ns.ac.rs/Archive Vol 20, No. 3-4, December 2012 contributing to reduce the number of unnecessary biopsies (21,22). Conners A.L et al, 2012 reported data selected from a database of over 3 000 examinations with 99mTc-Sestamibi performed on a dual-head cadmium-zinc-telluride (CZT) gamma camera mounted on a modified mammographic gantry.…”

Section: Role Of Scintimammography With the Cationic Lipophilic 99mtcmentioning

confidence: 99%

SPECT-CT in breast cancer

Sergieva¹,

Alexandrova²,

Baitchev³

et al. 2012

Arch Oncol

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The most important prognostic factors for breast cancer are the size of primary tumor and axillary lymph node status. Role of scintimammography with the cationic lipophilic 99mTc-Tetrofosmin and 99mTc-Sestamibi in preoperative evaluation and post-treatment follow-up of patients with breast cancer is well known. The added diagnostic value of SPECT-CT has recently been investigated. Scintigraphy provides a description of function or process whereas CT depicts the precise localization and type of morphological changes that have occurred in the lesions. Combined SPECT-CT imaging enables to localize positive primary tumors and/or loco-regional lymph nodes; to evaluate effect of neoadjuvant chemotherapy in locally advanced and non-operable breast tumors. SPECT-CT studies are useful in post-therapeutic follow-up of patients to visualize suspicious local recurrence, lymphadenopathy and disease extension. CT part of the study can increase the specificity of SPECT by more accurate anatomical assessment of the sites of abnormal activity with unclear character such as radiation pulmonitis, postoperative parenchymal changes, fibrocystic changes etc. According to the results reported in literature, all the axillary metastatic nodes that were false negative on SPECT image were non-palpable, small lesion size (<10 mm) with partial metastatic involvement or micrometastases in most cases. Lymphatic mapping of SLNs is now routinely done in breast cancer patients for correct N-staging. SPECT-CT has been used for clear depiction of the SLNs to provide the useful information for intraoperative gamma-probe detection in cases that are difficult to interpret planar images, in cases with unusual drainage or in cases of nonvisualization. SPECT-CT scintimammogarphy is preferable in terms of physical characteristic, execution time and cost-effectiveness, thus suggesting wider application of this procedure. SPECT-CT is a potential new tool for LN localization and radioguided surgery in the coming years

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“…3,8,9 In a similar fashion to the "Magic Bullet" concept of targeted therapy described by German physicist, Paul Ehrlich, TRNT is able to locate a specific tumour-associated target and deliver radioactive atoms to destroy it. 10,11 While standard chemotherapies commonly act indiscriminately on both normal and cancerous rapidly dividing cells, TRNT brings the radionuclide directly to the tumour via a specific, celltargeting vector. Once the radiopharmaceutical is retained at the site of action, the radiation that it produces can then kill the vicinal cancer cells.…”

Section: Introductionmentioning

confidence: 99%