1997
DOI: 10.1002/mrm.1910380306
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Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: Correlation with PET, microdialysis, and behavioral data

Abstract: The metabolic activation resulting from direct dopaminergic stimulation can be detected using auto-radiography, positron emission tomography (PET) or, potentially, fMRI techniques. To establish the validity of the latter possibility, we have performed a number of experiments. We measured the regional selectivity of two different dopaminergic ligands: the dopamine release compound D-amphetamine and the dopamine transporter antagonist 2 beta-carbomethoxy-3 beta-(4-fluoropheny) tropane (CFT). Both compounds led t… Show more

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Cited by 236 publications
(224 citation statements)
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“…Indeed, simultaneous measures of dopamine, blood flow and O 2 in rats have shown that terminal activity induced by stimulation of the VTA dopaminergic neurons increases blood flow in the caudate/putamen and caused an increase in local O 2 (Venton et al, 2003). Moreover, phMRI studies have shown that dopamine releasing agents or agents that block dopamine reuptake increase the BOLD signal in NAc (for review, Knutson and Gibbs, 2007) and that unilateral lesions of dopamine neurons in rat striatum abolished this effect (Chen et al, 1997;Chen et al, 1999;Knutson and Gibbs, 2007). Similarly, a neuroimaging study combining [ 11 C]raclopride positron emission tomography and fMRI showed a strong correlation between BOLD activation during reward anticipation and reward-related dopamine release in the ventral striatum in humans performing a monetary incentive delay task (Schott et al, 2008).…”
Section: Physiological Origin Of the O 2 Signalmentioning
confidence: 99%
“…Indeed, simultaneous measures of dopamine, blood flow and O 2 in rats have shown that terminal activity induced by stimulation of the VTA dopaminergic neurons increases blood flow in the caudate/putamen and caused an increase in local O 2 (Venton et al, 2003). Moreover, phMRI studies have shown that dopamine releasing agents or agents that block dopamine reuptake increase the BOLD signal in NAc (for review, Knutson and Gibbs, 2007) and that unilateral lesions of dopamine neurons in rat striatum abolished this effect (Chen et al, 1997;Chen et al, 1999;Knutson and Gibbs, 2007). Similarly, a neuroimaging study combining [ 11 C]raclopride positron emission tomography and fMRI showed a strong correlation between BOLD activation during reward anticipation and reward-related dopamine release in the ventral striatum in humans performing a monetary incentive delay task (Schott et al, 2008).…”
Section: Physiological Origin Of the O 2 Signalmentioning
confidence: 99%
“…The so-called blood oxygenation level-dependent (BOLD) signal can be used not only to study activity changes induced by sensory or cognitive stimuli but also changes induced by drugs, a variant that is termed pharmacological fMRI (phMRI). Several studies have been able to demonstrate BOLD signal increases following administration of non-selective dopamine agonists in animal models of PD (Chen et al, 1997(Chen et al, , 1999Nguyen et al, 2000;Kalisch et al, 2005). The value of this technique is demonstrated by the contrasting effects that apomorphine and the dopamine releasing compound amphetamine have on behavior and basal ganglia signal in rats with unilateral nigrostriatal lesions induced by 6-OHDA.…”
Section: Introductionmentioning
confidence: 99%
“…The value of this technique is demonstrated by the contrasting effects that apomorphine and the dopamine releasing compound amphetamine have on behavior and basal ganglia signal in rats with unilateral nigrostriatal lesions induced by 6-OHDA. Apomorphine induces contralateral turning behavior (an index of striatal denervation supersensitivity) and accordingly increases the BOLD signal on the lesioned side, whereas amphetamine produces ipsilateral turning (related to the extent of nigrostriatal damage) and increases BOLD on the intact side (Ungerstedt, 1976;Chen et al, 1997;Nguyen et al, 2000). This consistency between lateralized BOLD signal changes and well-characterized neurophysiological effects motivated us to compare, by means of phMRI, different selective and non-selective dopamine agonists in rats with unilateral nigrostriatal damage.…”
Section: Introductionmentioning
confidence: 99%
“…fMRI with drug challenges has consistently shown that D1-like agonism is associated with increased hemodynamics changes, while D2-like agonism is associated with negative hemodynamic changes 100103 . Data further show that hemodynamic changes (measured using either BOLD or CBV) are strongly correlated with dopamine release measured using microdialysis at high dopamine levels, and are mediated for opposing changes at low dopamine release levels due to the higher affinity of D2 over D1 receptors 104108 . Together, these animal data are surprisingly robust, with numerous studies across different dopamine antagonists and agonists of specific sub-types showing no exceptions to the coupling rules of D1/D5 yielding positive changes and D2/D3 yielding negative changes 11 .…”
Section: Multi-modal Imaging Of Receptor Functional Dynamics Witmentioning
confidence: 75%