Detection of DNA hybridization and extension reactions by an extended-gate field-effect transistor: Characterizations of immobilized DNA–probes and role of applying a superimposed high-frequency voltage onto a reference electrode

Kamahori, Masao; Ishige, Yu; Shimoda, Maki

doi:10.1016/j.bios.2007.10.013

Cited by 30 publications

(10 citation statements)

References 21 publications

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“…By converting the VDS–ID curve into VG using the VG–ID curve at constant VDS = 1 V, they were able to establish that the surface charge density changes due to DNA hybridization [ 32 ], and thus, by observing the change in surface charge density, they were able to detect DNA hybridization. This fully electric hybridization detection sensor has a detection limit of 7 fmol, provided that the probe density is 2.6 × 10 12 molecules/cm 2 [ 33 ].…”

Section: Vlsi Architectures In Dna Detectionmentioning

confidence: 99%

VLSI Structures for DNA Sequencing—A Survey

2020

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DNA sequencing is a critical functionality in biomedical research, and technical advances that improve it have important implications for human health. Novel methods by which sequencing can be accomplished in more accurate, high-throughput, and faster ways are in development. Here, we review VLSI biosensors for nucleotide detection and DNA sequencing. Implementation strategies are discussed and split into function-specific architectures that are presented for reported design examples from the literature. Lastly, we briefly introduce a new approach to sequencing using Gate All-Around (GAA) nanowire Metal Oxide Semiconductor Field Effect Transistors (MOSFETs) that has significant implications for the field.

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Section: Vlsi Architectures In Dna Detectionmentioning

confidence: 99%

VLSI Structures for DNA Sequencing—A Survey

2020

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“…The electronic integration can also benefit from the unique capability of DNA to self-assemble in programmable structures (46) to realize 2D or 3D dense integration of nanometer sized devices (47). Also, the integration of biomolecules provides electronic components with natural optimized interfaces for bio sensing (48).…”

Section: Electrical Conduction Of Dna and Nano-dot Coated Dna In Airmentioning

confidence: 99%

Silicon nanotweezers for biomechanical and bioelectrical assays

Collard¹

2013

Front Biosci

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In modern life, technologies enabling detection of biological molecules at a low threshold, for health and ecological concerns, are in high demand. Directly interrogating the molecules is a promising direction to clarify the noisy response of conventional assays arising from simultaneous different reactions. Besides sophisticated biophysical instrument such as the atomic force microscope, this paper proposes silicon nanotweezers (SNT) as a new microsystem for molecular manipulation. SNT can trap molecules and sense their biomechanical and bioelectrical response in minute operations. In this review SNT characteristics are overviewed; their operation modes are illustrated by molecule and cell trapping, manipulation and characterization in air and in solution. As they are tiny and can be mass produced by highly parallel microsystem technology, SNT can be seen as a potential molecular and cellular probe for routine analysis and bio detection.

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“…Since it is very important for FET-based biosensors to achieve good isolation between the device and the solution, extended gate field effect transistor is frequently used (Chen et al 2003;Ishige et al 2009;Kamahori et al 2007;Kamahori et al 2008;Kim et al 2006). The extended-gate field effect transistor consists of two parts: one a sensing structure containing the sensitive membrane and the other a MOSFET structure.…”

Section: Introductionmentioning

confidence: 99%

A field effect transistor (FET)-based immunosensor for detection of HbA1c and Hb

Bian

Tong

Sun

et al. 2010

Biomed Microdevices

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A field effect transistor (FET)-based immunosensor was developed for diabetes monitoring by detecting the concentrations of glycated hemoglobin (HbA1c) and hemoglobin (Hb). This immunosensor consists of a FET-based sensor chip and a disposable extended-gate electrode chip. The sensor chip was fabricated by standard CMOS process and was integrated with signal readout circuit. The disposable electrode chip, fabricated on polyester plastic board by Micro-Electro-Mechanical-Systems (MEMS) technique, was integrated with electrodes array and micro reaction pool. Biomolecules were immobilized on the electrode based on self-assembled monolayer and gold nanoparticles. Experimental results showed that the immunosensor achieved a linear response to HbA1c with the concentration from 4 to 24 μg/ml, and a linear response to Hb with the concentration from 60 to 180 μg/ml.

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Detection of DNA hybridization and extension reactions by an extended-gate field-effect transistor: Characterizations of immobilized DNA–probes and role of applying a superimposed high-frequency voltage onto a reference electrode

Cited by 30 publications

References 21 publications

VLSI Structures for DNA Sequencing—A Survey

VLSI Structures for DNA Sequencing—A Survey

Silicon nanotweezers for biomechanical and bioelectrical assays

A field effect transistor (FET)-based immunosensor for detection of HbA1c and Hb

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