Detection of Diphtheritic Polyneuropathy by Acute Flaccid Paralysis Surveillance, India

Mateen, Farrah J.; Bahl, Sunil; Khera, Ajay; Sutter, Roland W.

doi:10.3201/eid1909.130117

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…9 Mateen et al found palatal palsy only in 13% cases. 10 The onset of neurological complications in our series was seen from 6-51 days after respiratory symptoms. Similarly, in the Latvian study of 50 adult patients with diphtheritic paralysis, neurological complications appeared in 2-50 days (median, 10 days) after the onset of respiratory diphtheria.…”

Section: Discussionmentioning

confidence: 68%

A clinical study of complications of diphtheria

Arya

Maharia

Kadela

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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Background: Diphtheria is an acute infectious preventable disease of childhood caused by C. diphtheriae. Diphtheria is a localized infection of mucous membrane or skin.Methods: The present study was carried out in the Department of Otorhinolaryngology S.P. Medical College and associated group of hospital. In this study all cases of diphtheria and all age groups which attended ENT OPD and emergency department during period from 1/1/2010 to 31/12/2010 were included. Results: In the present study highest numbers of cases were recorded among 5-10 years of age followed by 0-5 year of age group. 57.59% patients were male and 42.41% patients were female. It was found that occurrence of diphtheria was highest in month November and October and was quit frequent during September and December. No cases during April, June and July. It was observed that most common post diphtheria complication was myocarditis (23.42%) followed by neurological complication.Conclusions: In order to prevent complication of the disease active immunization is customary and in order to detect the disease at early stage and for prompt treatment masses should be educated regarding the dreadful nature of the disease.

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Section: Discussionmentioning

confidence: 68%

A clinical study of complications of diphtheria

Arya

Maharia

Kadela

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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“…Causative role uncertain. PCR on fecal samples [ 30 ] Bacterial Diphtheria Africa, Central and South America, Asia, Europe Neurological toxicity from absorption and dissemination of diphtheria toxin Culture from throat and nose Need confirmation of toxin production [ 31 ] Lyme disease North America, Europe AFP is rare presentation Serological testing PCR on CSF [ 32 ] Botulism Worldwide Isolation of Clostridium botulinum from wound site Serum assay for botulinum toxin Electromyography [ 33 ] Rickettsia conorii Europe, Africa Cause of Mediterranean spotted fever. Rash very common.…”

Section: Discussionmentioning

confidence: 99%

Acute Flaccid Paralysis: The New, The Old, and The Preventable

Macesic

Hall

Mahony³

et al. 2015

Open Forum Infectious Diseases

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“…DP is a common and potentially severe complication occurring in ∼20% of diphtheria patients, although recovery is possible 12. Dysphagia and dysphonia secondary to hypopharyngeal and palatal muscle weakness tend to have an onset in the order of days to weeks, with segmental demyelination of peripheral nerves resulting in limb weakness, loss of tendon reflexes and sensory disturbance developing weeks to months after the initial infection 13–16.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary approach to the management of a case of classical respiratory diphtheria requiring percutaneous endoscopic gastrostomy feeding

Haywood¹,

Vijendren

Acharya

et al. 2017

BMJ Case Reports

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We present a case of a Caucasian woman aged 67 years referred with a 4-day history of sore throat, dysphagia, fever and nasal blockage. Examination revealed a swollen neck and pharyngeal pseudomembrane. A throat swab was positive on culture for , with toxin expression confirmed on PCR and Elek testing. A diagnosis of classical respiratory diphtheria was made, with subsequent confirmation of the patient's domesticated dog as the source of infection. The dog had recently been attacked by a wild badger and was being treated for an ear infection. The patient made a good recovery with intravenous antimicrobial and supportive therapy; however, she subsequently developed a diphtheritic polyneuropathy in the form of a severe bulbar palsy with frank aspiration necessitating percutaneous endoscopic gastrostomy feeding. A mild sensorimotor peripheral neuropathy was also diagnosed. The patient eventually made an almost complete recovery.

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Detection of Diphtheritic Polyneuropathy by Acute Flaccid Paralysis Surveillance, India

Cited by 16 publications

References 18 publications

A clinical study of complications of diphtheria

A clinical study of complications of diphtheria

Acute Flaccid Paralysis: The New, The Old, and The Preventable

Multidisciplinary approach to the management of a case of classical respiratory diphtheria requiring percutaneous endoscopic gastrostomy feeding

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