Detection of Coronary Stenoses and Quantification of the Degree and Spatial Extent of Blood Flow Mismatch During Coronary Hyperemia With Myocardial Contrast Echocardiography

Ismail, Suad; Jayaweera, Ananda R.; Goodman, Norman C.; Camarano, Gustavo; Skyba, Danny M.; Kaul, Sanjiv

doi:10.1161/01.cir.91.3.821

Cited by 56 publications

(8 citation statements)

References 19 publications

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“…It can also be used to assess the presence and extent of collateral perfusion during acute coronary occlusion and its impact on myocardial viability [30, 31]. MCE has also been used successfully for the detection of stable chronic coronary artery disease in the absence of prior infarction [32, 35]. …”

Section: Role Of Myocardial Contrast Echocardiography In Clinical Pramentioning

confidence: 99%

Myocardial Contrast Echocardiography in the Evaluation of Hypertensive Heart Disease

Madu

2011

Cardiol Res

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Myocardial contrast echocardiography (MCE) has an established role in left ventricular assessment by improving the ventricular opacification and endocardial border definition especially in patients with sub-optimal echocardiographic images. With advances in cardiac ultrasound imaging technology and the development of new contrast agents, the clinical utility of this technique has greatly expanded to include assessment of coronary reperfusion in the setting of acute myocardial infarction, determination of myocardial viability within infarct zones as well as assessment of coronary microcirculation and flow reserve in patients with microvascular coronary disease. Improvements in image quality with intravenous contrast agents can facilitate image acquisition and enhance delineation of regional wall motion abnormalities at peak levels of exercise. Numerous studies have confirmed the clinical utility of contrast enhancement during echocardiographic studies, particularly in patients undergoing stress testing. In this paper, we explore the evidence in support of MCE and its potential clinical applications. Our review aims to summarize (1) the basic principles of myocardial contrast echocardiography including recent advances in the ultrasound technology and contrast agents (2) its clinical applications in the diagnosis of cardiovascular diseases and finally, (3) its potential role in risk stratification and assessment of microvascular perfusion in patients with hypertensive heart disease.

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Section: Role Of Myocardial Contrast Echocardiography In Clinical Pramentioning

confidence: 99%

Myocardial Contrast Echocardiography in the Evaluation of Hypertensive Heart Disease

Madu

2011

Cardiol Res

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“…Experimental studies had previously demonstrated the ability of MCE to detect coronary stenosis and to quantify the degree of MBF mismatch during pharmacological stress. [62][63][64] Studies also showed that coronary stenosis can be detected 65,66 and abnormal coronary blood flow reserve can be accurately measured 67 with MCE in humans with venous administration of microbubbles.…”

Section: Mce For Cad Detectionmentioning

confidence: 99%

Myocardial Contrast Echocardiography

Kaul

2008

Circulation

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117

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“…18 During adenosine or dipyridamole vasodilation in dogs, peak MVI ratios within different myocardial regions following bolus injections of microbubbles have been shown to correlate closely with MBF ratios determined with radioactive microspheres. 19,20 When using intermittent harmonic imaging during dobutamine or adenosine stress, the peak MVI ratios (stenosed divided by normally perfused bed) correlate closely with minimal lumen diameter of the stenosed artery. 21 These animal studies led to the rst comparative studies in humans.…”

Section: Stress Echocardiographymentioning

confidence: 99%

Myocardial Contrast Echocardiography: A New Gold Standard for Perfusion Imaging?

Porter

Cwajg

2001

Echocardiography

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Recent developments have permitted myocardial contrast echocardiography (MCE) to become a new method of noninvasively assessing myocardial perfusion in humans. Preliminary studies of myocardial perfusion imaging during adenosine, dipyridamole, and dobutamine stress echocardiography have shown excellent agreement with either radionuclide uptake or quantitative angiography. This article reviews the recent advances in microbubble technology, ultrasound imaging, and myocardial physiology that have made contrast echocardiography a potential new gold standard for perfusion imaging in the new millennium.

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Detection of Coronary Stenoses and Quantification of the Degree and Spatial Extent of Blood Flow Mismatch During Coronary Hyperemia With Myocardial Contrast Echocardiography

Cited by 56 publications

References 19 publications

Myocardial Contrast Echocardiography in the Evaluation of Hypertensive Heart Disease

Myocardial Contrast Echocardiography in the Evaluation of Hypertensive Heart Disease

Myocardial Contrast Echocardiography

Myocardial Contrast Echocardiography: A New Gold Standard for Perfusion Imaging?

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