Detection of compatibility between baclofen and excipients with aid of infrared spectroscopy and chemometry

Rojek, Barbara; Wesołowski, Marek; Suchacz, Bogdan

doi:10.1016/j.saa.2013.07.102

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…Several techniques have been applied in compatibility studies with excipients, such as differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), X-ray diffraction (XRD), solid-state nuclear magnetic resonance (ssNMR) and isothermal stress testing (IST) coupled with liquid chromatography (LC) (Chadha and Bhandari, 2014). Some of these techniques are more commonly used due to fast analyses, low material consumption, and the ability to detect impurities/degradation products (Chadha and Bhandari, 2014, Pires et al, 2017, Rojek et al, 2013, Verma and Garg, 2005).…”

Section: Introductionmentioning

confidence: 99%

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

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Rosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, and based on its pharmacological potential and poor bioavailability, several solid dosage forms have been developed to RA delivery. Therefore, in literature, there are no reports about RA compatibility with excipients. In this regard, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms at a 1:1 (RA:excipient) ratio using differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), solid-state nuclear magnetic resonance (ssNMR), and isothermal stress testing (IST) coupled with liquid chromatography (LC). The excipients selected were hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), lactose monohydrate (LAC), polyvinylpyrrolidone (PVP), talc (TALC), croscarmellose sodium (CCS), and magnesium stearate (MgSTE). According to DSC results, physical interactions were found between RA and HPMC, LAC, CCS, and MgSTE. The TG analyses confirmed the physical interactions and suggested chemical incompatibility. FTIR revealed physical interaction of RA with TALC and MgSTE and the ssNMR confirmed the physical interaction showed by FTIR and excluded the presence of chemical incompatibility. By IST, the greatest loss of RA content was found to CCS and MgSTE (>15%), demonstrating chemical incompatibilities with RA. High temperatures used in DSC and TG analyses could be responsible for incompatibilities in binary mixtures (BMs) with HPMC and LAC, while temperature above 25 °C and presence of water were factors that promote incompatibilities in BMs with CCS and MgSTE. Overall results demonstrate that RA was compatible with MCC and PVP.

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Section: Introductionmentioning

confidence: 99%

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

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“…The FTIR method always acts as a non-destructive complementary method, for the detection of possible interactions between the components. If the FTIR measurement for a mixture were a combination of the characteristic peaks, without any absence, shift or substantial broadening of the peaks, of the individual components, then no interactions could be inferred [37,38].…”

Section: Infrared Analysismentioning

confidence: 99%

Pre-formulation Compatibility Studies of 5-Amino-1H-tetrazole Nitrate with Several Typical Materials by Thermal and Non-thermal Techniques

Guo¹,

Han²,

Lin³

et al. 2018

Cent. Eur. J. Energ. Mater.

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The aim of the present study was to assess the physicochemical compatibility of a promising energetic salt, 5-amino-1H-tetrazole nitrate (5-ATN), with some typical materials. Thermal techniques (differential scanning calorimetry (DSC) and vacuum stability test (VST)) and non-thermal techniques (X-ray diffractometry (XRD) and Fourier Transform Infrared Spectroscopy (FTIR)) were applied. Five energetic materials (TNT, RDX, HMX, CL-20 and AP) and three common additives (Al, DOS and F2604-2) were tested to evaluate their compatibility with 5-ATN. Based on the DSC results, except for AP that was only partially compatible with 5-ATN, all of the selected materials exhibited good compatible with 5-ATN. The VST test further confirmed the compatibility of the 5-ATN/AP mixtures. Combined with the thermal methods, the FTIR results agreed with the DSC findings. The XRD results showed some differences.

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“…They are non-destructive and extremely useful for providing structural information about molecules in terms of their functional groups, the orientation of those groups and information on isomers. In association with chemometric methods they can also be used to provide quantitative information [14][15][16]. IR and Raman spectroscopies are similar insofar as they both produce spectra based on vibrational transitions within a molecule and use the same spectral regions [6].…”

Section: Infrared and Raman Spectroscopymentioning

confidence: 99%

“…4) consist of a complex series of sharp peaks corresponding to the vibrations of spectral groups within the molecule. Two spectral ranges, 3,600-2,800 cm -1 and 1,800-1,000 cm -1 , were chosen for interpretation [15]. The fingerprint region (1,800-1,000 cm -1 ) is most valuable because it is partially devoid of absorption bands arising from excipients, and thus enables a better recognition of changes in the structure of the Mg salts.…”

Section: Infrared and Raman Spectroscopymentioning

confidence: 99%

“…A screening of the literature data has shown that among others, thermoanalytical and spectroscopic techniques can be used to a large extent in the drug and food analysis. Numerous papers published recently revealed some examples of usefulness of differential scanning calorimetry (DSC) [7][8][9][10][11], thermogravimetry (TG) [7,8,12,13], Fourier-transform infrared (FTIR) [10,[13][14][15], near infrared (NIR) [11,14,16] and Raman [9,14,[17][18][19][20] techniques for analytical purposes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of magnesium compounds in dietary supplements and medicinal products by DSC, Infrared and Raman techniques

Wesołowski

Leyk

Szynkaruk

2014

J Therm Anal Calorim

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The aim of this study was to learn to what extent the selected instrumental techniques, differential scanning calorimetry (DSC), as well as Fourier-transform infrared (FTIR) and Raman spectroscopies, can be used to detect both organic or inorganic magnesium compounds in the dietary supplements and medicinal products. Besides magnesium compounds as the active pharmaceutical ingredients (APIs), the preparations contain also other organic and inorganic APIs and several excipients. The study will be extended over the analysis of the products manufactured by various firms but containing the same API at different levels. In this way, it will be possible to assess the impact of excipients on the DSC scans and the FTIR and Raman spectra of a dominant constituent present in a studied preparation. The study on thirty commercially available dietary supplements and medicinal products has shown that in the majority of cases the DSC, FTIR and Raman techniques could be used for the detection of APIs in these commercial products. This was possible with the aid of the endothermic DSC peaks and the so-called matching factors of the FTIR and Raman spectra to those of substances used as standards. Both the complex composition and low levels of API in the studied preparations have been identified as the factors which have a strong impact on the usefulness of the three techniques for the detection of APIs in the dietary and medicinal products.

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Detection of compatibility between baclofen and excipients with aid of infrared spectroscopy and chemometry

Cited by 11 publications

References 11 publications

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Pre-formulation Compatibility Studies of 5-Amino-1H-tetrazole Nitrate with Several Typical Materials by Thermal and Non-thermal Techniques

Detection of magnesium compounds in dietary supplements and medicinal products by DSC, Infrared and Raman techniques

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