Detection of cocaine and its metabolites in urine using solid phase extraction-ion mobility spectrometry with alternating least squares

Lu, Yao; O’Donnell, Ryan M.; Harrington, Peter de B.

doi:10.1016/j.forsciint.2009.04.007

Cited by 47 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The previously reported K0 value was 1.16. 35 From the experimental results, we can conclude that the new IMS equipped with corona discharge ionization source had excellent detection limit of cocaine (0.02 ng) and relatively good reproducibility.…”

mentioning

confidence: 80%

“…Recently, it has been analyzed using IMS. 11,[35][36][37] Lu and coworkers 35 analyzed cocaine and its metabolites, benzoylecgonine and cocaethylene in urine using solid phase extraction (SPE) coupled with IMS, and reported that the detection limits of benzoylecgonine and cocaethylene are 10 ng/mL (10 ppb) and 4 ng/mL (40 ppb), respectively. Dussy and coworkers 36 examined the validation of a qualitative IMS procedure for the detection of trace amounts of cocaine on incriminated material using a vacuum cleaner for sampling and reported that the detection limit of cocaine was 0.2 ng.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Choi¹,

Kim²,

Kim³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

Ion mobility spectrometry (IMS) was a technique originally applied for the detection of trace compounds. 1-3 IMS has been widely used to detect chemical warfare agents, 4-6 explosives, [7][8][9][10] and illegal drugs 10-13 since it combines both high sensitivity (detection limits down to the ng/L range to pg/L range, ppb range and ppt range) and relatively low technical expenditure with high-speed data acquisition. The time required to acquire a single spectrum is in the range of several tens ms. The working principle is based on the drift of ions at ambient pressure under the influence of an external electric field. 14-20 IMS works in a similar way to a time-of-flight mass spectrometer (TOFMS). The major difference is that TOFMS requires a vacuum but IMS does not. The mean free path of the ions in IMS is very smaller than in TOFMS. A typical IMS is comprised of an ionization source associated with an ion reaction chamber, an ion drift tube, an ion/molecule injection shutter placed between the ion reaction chamber and the ion drift tube, and an ion collector (detector, Faraday plate). An ion swarm drifting under the electric field experiences a separation process based on ions with different masses or structures having different drift velocities. Collecting these ions on a Faraday plate delivers a time-dependent signal corresponding to the mobility of the arriving ions. This ion mobility spectrum contains information on the nature of the different trace compounds present in the sample gas.Mass spectrometry is an important tool for the structural analysis of unknown chemicals. Soft ionization techniques such as matrix-assisted laser desorption and ionization (MALDI) and atmospheric pressure ionization (API) have been used for determination of molecular weight of an analyte. [21][22][23][24][25][26][27][28][29][30][31][32][33][34] Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are the most currently used as API sources. In APCI, a corona discharge makes solvent reactant ions that are used to ionize the analyte by chemical ionization. [31][32][33][34] Solvent and analyte are vaporized by pneumatic nebulization. APCI relies upon gas-phase ion-molecule reactions to place a charge on neutral analytes, so it is especially important to understand these reactions. The solvent-derived ions serve as reagents for proton transfer ionization.Cocaine is a powerfully addictive drug because of its instantaneous and overwhelming effects on the central nervous system. It is generally analyzed by gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), GC, or LC. Recently, it has been analyzed using IMS. 11,[35][36][37] Lu and coworkers 35 analyzed cocaine and its metabolites, benzoylecgonine and cocaethylene in urine using solid phase extraction (SPE) coupled with IMS, and reported that the detection limits of benzoylecgonine and cocaethylene are 10 ng/mL (10 ppb) and 4 ng/mL (40 ppb), respectively. Dussy and coworkers 36 examined the validation of a qualita...

show abstract

mentioning

confidence: 80%

mentioning

confidence: 99%

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Choi¹,

Kim²,

Kim³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

show abstract

“…Quando consumida, essa substância é rapidamente metabolizada e convertida, quase em sua totalidade, em produtos de biotransformação, sendo eliminada na urina como benzoilecgonina (15 a 50%), ecgonina métil éster (15 a 35%), ecgonina (1 a 8%), norcocaína (2 a 6%) e A B na forma inalterada (cerca de 3%). O seu principal produto de biotransformação, a benzoilecgonina (Figura 1), é usualmente monitorado em amostras de urina para verificar a exposição à cocaína [4][5][6] . A urina, por sua vez, é considerada a matriz biológica de escolha para monitorar o uso de drogas ilícitas, pois apresenta coleta simples, de forma não invasiva, além de possuir uma ampla janela de detecção quando comparada ao sangue, permitindo a análise de substâncias com um intervalo de tempo maior entre a exposição e o procedimento laboratorial [7][8][9] .…”

Section: Segundo O úLtimo Relatório Publicado Pelo United Nations Offunclassified

Estimativa Da Incerteza De Medição Em Análises De Benzoilecgonina Em Urina Por Gc-Ms

Eller¹,

Takai²,

Oliveira³

et al. 2016

BJFS

View full text Add to dashboard Cite

Abstract:Epidemiological studies indicate that the consumption of illegal substances is associated with a serious public health problem. To sum up, the present situation demands an immediate action, with major focus on reliable analytical methods which can be capable of detecting such compounds in biological fluids. Furthermore, the application of drug analysis in urine has increased significantly and for this reason, forensic toxicologists are being asked to determine and report their measurement uncertainty (MU) in drug analysis. The purpose of this study was to estimate the MU of confirmatory toxicological analysis of benzoylecgonine in urine by GC-MS. The limit of detection was 5.0 ng.ml -1 . The calibration curves were linear over the specified range (7.5 -3200 ng.ml

show abstract

“…To obtain accurate, reliable and sensitive results for the IMS analysis of clinical samples, sample preparation methods, including extraction, preconcentration, and cleanup, are required [19][20][21][22][23].…”

Section: Analysis Of Complex Clinical Samplesmentioning

confidence: 99%

Spray nebulization for sample introduction in ion mobility spectrometry

Armenta

Gonzálvez

Blanco

2013

Analytica Chimica Acta

View full text Add to dashboard Cite

Detection of cocaine and its metabolites in urine using solid phase extraction-ion mobility spectrometry with alternating least squares

Cited by 47 publications

References 17 publications

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Estimativa Da Incerteza De Medição Em Análises De Benzoilecgonina Em Urina Por Gc-Ms

Spray nebulization for sample introduction in ion mobility spectrometry

Contact Info

Product

Resources

About