Detection of Circulating Galactomannan in Serum Samples for Diagnosis of<i>Penicillium marneffei</i>Infection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

Huang, Yu-Tsung; Hung, Chien‐Ching; Liao, Chun-Hsing; Sun, Hsin‐Yun; Chang, Shan-Chwen; Chen, Yee‐Chun

doi:10.1128/jcm.00050-07

Cited by 89 publications

(54 citation statements)

References 22 publications

(30 reference statements)

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“…Second, false positive reactions may occur owing to a variety of factors, including administration of b lactam antibiotics (Pinel et al 2003) or infusion of gluconate-containing Plasma-Lyte (Petraitiene et al 2011). Third, there is considerable cross-reactivity with other fungi producing disseminated infection (Huang et al 2007;Wheat et al 2007;Xavier et al 2009). …”

Section: Galactomannanmentioning

confidence: 99%

Fungal Diagnostics

Kozel

Wickes²

2014

Cold Spring Harbor Perspectives in Medicine

144

108

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Early diagnosis of fungal infection is critical to effective treatment. There are many impediments to diagnosis such as a diminishing number of clinical mycologists, cost, time to result, and requirements for sensitivity and specificity. In addition, fungal diagnostics must meet the contrasting needs presented by the increasing diversity of fungi found in association with the use of immunosuppressive agents in countries with high levels of medical care and the need for diagnostics in resource-limited countries where large numbers of opportunistic infections occur in patients with AIDS. Traditional approaches to diagnosis include direct microscopic examination of clinical samples, histopathology, culture, and serology. Emerging technologies include molecular diagnostics and antigen detection in clinical samples. Innovative new technologies that use molecular and immunoassay platforms have the potential to meet the needs of both resource-rich and resource-limited clinical environments.

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Section: Galactomannanmentioning

confidence: 99%

Fungal Diagnostics

Kozel

Wickes²

2014

Cold Spring Harbor Perspectives in Medicine

144

108

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“…Although there are no established tests for the definitive serodiagnosis of PMI, circulating galactomannans may be an indicator of PMI (14). Glucans are a major constituent of the cell walls of pathogenic fungi (with the exceptions of the Mucor, Rhizopus, Blastomyces dermatitidis, and Cryptococcus species) (15).…”

Section: Discussionmentioning

confidence: 99%

<i>Penicillium marneffei</i> Infection with β-D-glucan Elevation: A Case Report and Literature Review

et al. 2016

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We herein report a case of Penicillium marneffei infection (PMI) in a Japanese man who was infected with human immunodeficiency virus-1 (HIV-1), who was diagnosed on the basis of a bone marrow culture and who was effectively treated with itraconazole. Our review of the PMI cases reported in Japan suggests that increased serum (1 3)-β-D-glucan levels are a useful diagnostic tool in cases of suspected PMI.

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“…The assay had a reported sensitivity of 56 % in liver transplant recipients and only 30 % in lung transplant recipients indicating that this assay when used in serum may not have a diagnostic role in these populations [30, 31]. The assay has also been examined in serum samples from HIV infected patients diagnosed with penicilliosis (15), cryptococcosis (22) and 11 HIV infected patients with no IFI (controls) [32]. The ODI was significantly elevated in those with penicilliosis indicating that the test may have a role for the early diagnosis of this infection in endemic areas.…”

Section: Serological Markers For the Diagnosis Of Ifimentioning

confidence: 99%

Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections

Morrissey

2013

Curr Fungal Infect Rep

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Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure even with the availability of new more potent and less toxic antifungal agents. New non-culture-based serological and PCR assays have been developed. These appear more sensitive and are able to make an earlier diagnosis as compared with traditional diagnostic methods. Early diagnosis is central to reducing IFI-related morbidity and mortality. This review describes the diagnostic potential of the new serological and PCR assays and outlines how these assays have been incorporated into algorithms to improve the management of IFI.

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Detection of Circulating Galactomannan in Serum Samples for Diagnosis ofPenicillium marneffeiInfection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

Abstract: Galactomannan (GM) is a heteropolysaccharide in the cell walls of most

Cited by 89 publications

References 22 publications

Fungal Diagnostics

Fungal Diagnostics

<i>Penicillium marneffei</i> Infection with β-D-glucan Elevation: A Case Report and Literature Review

Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections

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