Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections

Morrissey, C. Orla

doi:10.1007/s12281-012-0128-4

Cited by 15 publications

(8 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high mortality rates associated with invasive infections occur despite the availability of antifungals with less toxicity and improved potency [9] . Early treatment has been related to better outcomes, but this is dependent on diagnostic tests that are both rapid and highly sensitive [12] . As traditional histology- and culture-based methods have poor sensitivity and often only make a diagnosis late when the fungal burden is high, research has turned its focus to developing improved molecular and serological assays [12] .…”

Section: Discussionmentioning

confidence: 99%

“…Early treatment has been related to better outcomes, but this is dependent on diagnostic tests that are both rapid and highly sensitive [12] . As traditional histology- and culture-based methods have poor sensitivity and often only make a diagnosis late when the fungal burden is high, research has turned its focus to developing improved molecular and serological assays [12] . Several Trichosporon -specific tests have been developed in the last two decades, including PCR-based methods, flow cytometry, and proteomics [3] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Maxfield¹,

Matthews²,

Ambrosetti³

et al. 2015

IDCases

View full text Add to dashboard Cite

Trichosporon fungemia is a life-threatening opportunistic infection that is increasing in frequency. Invasive disease occurs almost exclusively in immunocompromised hosts, particularly in neutropenic adults with hematological malignancies and uncommonly in children. We report the case of a pediatric patient where disseminated trichosporonosis progressed while on micafungin, between treatments with voriconazole and amphotericin B, demonstrating the difficulty with and importance of prolonged and continuous treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Maxfield¹,

Matthews²,

Ambrosetti³

et al. 2015

IDCases

View full text Add to dashboard Cite

show abstract

“…Many of the fungi in these groups are ubiquitous in nature and are not necessarily pathogenic. However, within the past few years a number of clinical cases involving infections by these fungi have been detected (mainly respiratory, skin and nail infections) (Nucci and Anaissie, 2007;Cortez et al, 2008;Knutsen and Slavin, 2011;Morrissey, 2013). Most of these cases have involved patients who are immunocompromised, and thus, relatively more vulnerable to infection by opportunistic pathogens.…”

Section: Fungimentioning

confidence: 99%

Routine screening of harmful microorganisms in beach sands: Implications to public health

Sabino

Rodrigues

Costa

et al. 2014

Science of The Total Environment

View full text Add to dashboard Cite

Beaches worldwide provide recreational opportunities to hundreds of millions of people and serve as important components of coastal economies. Beach water is often monitored for microbiological quality to detect the presence of indicators of human sewage contamination so as to prevent public health outbreaks associated with water contact. However, growing evidence suggests that beach sand can harbor microbes harmful to human health, often in concentrations greater than the beach water. Currently, there are no standards for monitoring, sampling, analyzing, or managing beach sand quality. In addition to indicator microbes, growing evidence has identified pathogenic bacteria, viruses, and fungi in a variety of beach sands worldwide. The public health threat associated with these populations through direct and indirect contact is unknown because so little research has been conducted relating to health outcomes associated with sand quality. In this manuscript, we present the consensus findings of a workshop of experts convened in Lisbon, Portugal to discuss the current state of knowledge on beach sand microbiological quality and to develop suggestions for standardizing the evaluation of sand at coastal beaches. The expert group at the "Microareias 2012" workshop recommends that 1) beach sand should be screened for a variety of pathogens harmful to human health, and sand monitoring should then be initiated alongside regular water monitoring; 2) sampling and analysis protocols should be standardized to allow proper comparisons among beach locations; and 3) further studies are needed to estimate human health risk with exposure to contaminated beach sand. Much of the manuscript is focused on research specific to Portugal, but similar results have been found elsewhere, and the findings have worldwide implications.

show abstract

“…Invasive candidiasis (IC) continues to be a life-threatening infectious disease affecting an ever-increasing number of hospitalized patients and, of particular concern, causing considerably high morbidity and mortality. In the USA, Candida species is among the five major pathogens leading to nosocomial blood stream infections (BSIs) and causing 8–10% of nosocomial BSIs (Pappas, 2006 ; Pfaller and Diekema, 2007 ; Morrissey, 2013 ; Sievert et al, 2013 ). Though a variety of Candida species can produce invasive infection, Candida albicans ( C. albicans ) continues to be identified as a leading pathogen.…”

Section: Introductionmentioning

confidence: 99%

Serological response and diagnostic value of recombinant candida cell wall protein enolase, phosphoglycerate kinase, and β-glucosidase

Chen

et al. 2015

Front. Microbiol.

View full text Add to dashboard Cite

There are no specific signs and symtoms for invasive candidiasis (IC), which makes its diagnosis a challenge. Efforts have been made for decades to establish serological assays for rapid diagnosis of IC, but none of them have found widespread clinical use. Using a systemic candiasis murine model, serological response to recombinant proteins of enolase (rEno1), phosphoglycerate kinase (rPgk1), and β-glucosidase (rBgl2) were evaluated and rEno1 was found to possess the strongest immunoreactivity, followed by rPgk1 and rBgl2. Likewise, IgG antibody titers to rEno1, rPgk1, and rBgl2 in the positive sera of proven IC patients were determined by ELISA. Results show anti-rEno1 antibody possesses the highest titer, followed by rPgk1 and rBgl2. Antibodies against rEno1, rPgk1, and rBgl2 were detected by ELISA tests in a group of 52 proven IC patients or 50 healthy subjects, The sensitivity, specificity, positive and negative predictive values were 88.5, 90.0, 90.2, and 88.2% for anti-rEno1 detection, 86.5, 92.0, 91.8, and 86.8% for anti-rPgk1 detection, and 80.8, 90.0, 89.4, and 81.8% for anti-rBgl2 detection, respectively. The data clearly demonstrate that the recombinant proteins of Eno1, Pgk1, and Bgl2 are promising candidates for IC serodiagnosis. There's great possibility that the recombinant Eno1 will be more applicable in serodiagnosis and vaccine research on account of its strong serological response.

show abstract

Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections

Cited by 15 publications

References 67 publications

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Routine screening of harmful microorganisms in beach sands: Implications to public health

Serological response and diagnostic value of recombinant candida cell wall protein enolase, phosphoglycerate kinase, and β-glucosidase

Contact Info

Product

Resources

About