Detection of Ciprofloxacin-Resistant, <i>β</i>-Lactamase–Producing <i>Neisseria meningitidis</i> Serogroup Y Isolates — United States, 2019–2020

McNamara, Lucy A.; Cubeñas-Potts, Caelin; Blain, Amy; Retchless, Adam C.; Reese, Natashia; Swint, Stephanie; Lonsway, David; Karlsson, Maria; Lunquest, Kristy; Sweitzer, John; Wang, Xin; Hariri, Susan; Fox, LeAnne M.; Dhungana, Nirmala; Gabrio-Brannon, Ryan; Kyle, Jennifer L.; Martin, Brittany; Barnes, Meghan; Moore, Ashley; Hannagan, Susan; Keating, Page; Li, Sandy; Albertson, Justin; Fleming, Wayne; Lurie, Perrianne; Russell, Christina; Reid, Kara; Sanders, Kelsey; DeBolt, Chas; Graff, Nicholas; Lam, Esther; Hanisch, Benjamin; Taormina, Gillian

doi:10.15585/mmwr.mm6924a2

Cited by 45 publications

(24 citation statements)

References 8 publications

(8 reference statements)

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“…As the present study constituted a genomic survey, we focussed on antibiotic resistance/reduced susceptibility determinants commonly associated with cc4821, rather than phenotypic MICs. Further work may include consideration of other potential resistance determinants such as multidrug efflux systems or beta lactamase, the latter of which has recently been reported among meningococci in North America and Europe [ 37 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…A small number of well distributed isolates also possessed mutant parC alleles that may further increase fluoroquinolone MICs. Notably, the RoW cluster does not possess a mutant gyrA, however, it may be susceptible to stable acquisition of fluoroquinolone resistance given the situation in the broader clonal complex and the gradual emergence of fluoroquinolone resistance in Western countries [35,[37][38][39]. Interestingly, all of the RoW isolates possessed a mutant penA allele associated with reduced penicillin susceptibility (0.094 to 1 mg/L).…”

Section: Discussionmentioning

confidence: 99%

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Genomic analysis of the meningococcal ST-4821 complex–Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage

Lucidarme

Zhu

et al. 2020

PLoS ONE

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Introduction The ST-4821 complex (cc4821) is a leading cause of serogroup C and serogroup B invasive meningococcal disease in China where diverse strains in two phylogenetic groups (groups 1 and 2) have acquired fluoroquinolone resistance. cc4821 was recently prevalent among carriage isolates in men who have sex with men in New York City (USA). Genome-level population studies have thus far been limited to Chinese isolates. The aim of the present study was to build upon these with an extended panel of international cc4821 isolates. Methods Genomes of isolates from Asia (1972 to 2017), Europe (2011 to 2018), North America (2007), and South America (2014) were sequenced or obtained from the PubMLST Neisseria database. Core genome comparisons were performed in PubMLST. Results Four lineages were identified. Western isolates formed a distinct, mainly serogroup B sublineage with alleles associated with fluoroquinolone susceptibility (MIC <0.03 mg/L) and reduced penicillin susceptibility (MIC 0.094 to 1 mg/L). A third of these were from anogenital sites in men who have sex with men and had unique denitrification gene alleles. Generally 4CMenB vaccine strain coverage was reliant on strain-specific NHBA peptides. Discussion The previously identified cc4821 group 2 was resolved into three separate lineages. Clustering of western isolates was surprising given the overall diversity of cc4821. Possible association of this cluster with the anogenital niche is worthy of monitoring given concerns surrounding antibiotic resistance and potential subcapsular vaccine escape.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genomic analysis of the meningococcal ST-4821 complex–Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage

Lucidarme

Zhu

et al. 2020

PLoS ONE

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“…In addition, there is not a large threat of antibiotic resistance with this pathogen. Quite recently, however, there have been reports of an uptick in penicillin- and/or ciprofloxacin-resistant cases N. meningitidis serogroup Y [ 35 ]. There are several bacterial species that are resistant to antibiotics.…”

Section: Chemoenzymatic Synthesis Of Meningococcal Oligosaccharidesmentioning

confidence: 99%

Recent and Future Advances in the Chemoenzymatic Synthesis of Homogeneous Glycans for Bacterial Glycoconjugate Vaccine Development

Adegbite

McCarthy

2021

Vaccines

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Vaccines are important in preventing disease outbreaks and controlling the spread of disease in a population. A variety of vaccines exist, including subunit, recombinant, and conjugate vaccines. Glycoconjugate vaccines have been an important tool to fight against diseases caused by a number of bacteria. Glycoconjugate vaccines are often heterogeneous. Vaccines of the future are becoming more rationally designed to have a defined oligosaccharide chain length and position of conjugation. Homogenous vaccines could play an important role in assessing the relationship between vaccine structure and immune response. This review focuses on recent advances in the chemoenzymatic production of defined bacterial oligosaccharides for vaccine development with a focus on Neisseria meningitidis and selected WHO-prioritized antibacterial resistant-pathogens. We also provide some perspective on future advances in the chemoenzymatic synthesis of well-defined oligosaccharides.

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“…In early 2020, two β-lactamase-producing MenY isolates were detected in the United States; however, in addition to containing bla ROB-1 , these isolates were also resistant to ciprofloxacin 41 A call for MenY isolates from across the USA led to the finding of 33 β-lactamase positive isolates (2013–2020); 11 were also ciprofloxacin-resistant (2019–2020). Twenty-two of the 33 cases were recovered from Hispanic individuals.…”

Section: Introductionmentioning

confidence: 99%

Surveillance and control of meningococcal disease in the COVID-19 era: A Global Meningococcal Initiative review

Alderson

Arkwright

Bai

et al. 2022

Journal of Infection

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Detection of Ciprofloxacin-Resistant, β-Lactamase–Producing Neisseria meningitidis Serogroup Y Isolates — United States, 2019–2020

Cited by 45 publications

References 8 publications

Genomic analysis of the meningococcal ST-4821 complex–Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage

Genomic analysis of the meningococcal ST-4821 complex–Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage

Recent and Future Advances in the Chemoenzymatic Synthesis of Homogeneous Glycans for Bacterial Glycoconjugate Vaccine Development

Surveillance and control of meningococcal disease in the COVID-19 era: A Global Meningococcal Initiative review

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