Detection of Chlamydia trachomatis in fallopian tube tissue in women with postinfectious tubal infertility

Patton, Dorothy L.; Askienazy-Elbhar, M.; Henry-Suchet, J; Campbell, Lee Ann; Cappuccio, Alison L.; Tannous, W; Wang, San Pin; Kuo, Cho‐Chou

doi:10.1016/s0002-9378(94)70084-2

Cited by 140 publications

(80 citation statements)

References 17 publications

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“…Chlamydia antigen, DNA and RNA have been detected in human patients that were culture-negative (Rahman et al, 1992;Patton et al, 1994;Gerard et al, 1998), suggesting the presence of unculturable Chlamydia organisms that remain within hosts. In mice, the immune system itself may induce Chlamydia organisms into an unculturable form.…”

Section: Trachomatis Persistence and Immunopathologymentioning

confidence: 99%

Immune-mediated control of Chlamydia infection

Roan

Starnbach²

2007

Cell Microbiol

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SummaryInfection with the bacterium Chlamydia trachomatis can lead to a variety of diseases, including ectopic pregnancy, infertility and blindness. Exposure of the host to C. trachomatis stimulates multiple innate and adaptive immune effectors that can contribute towards controlling bacterial replication. However, these effectors are often insufficient to resolve the infection and prevent re-infection, and the continued presence of C. trachomatis within the host may induce immune effectors to chronically produce inflammatory cytokines. This may eventually lead to the tissue pathologies associated with the infection. Reducing the incidence and sequelae of infection will ultimately require the development of a C. trachomatis vaccine that can stimulate sterilizing immunity while avoiding immune-mediated pathology.

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Section: Trachomatis Persistence and Immunopathologymentioning

confidence: 99%

Immune-mediated control of Chlamydia infection

Roan

Starnbach²

2007

Cell Microbiol

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“…The fact that symptoms of genital chlamydial infections are vague and that they may run a chronic course, e.g. in the fallopian tubes 9,10 , further stress the need for rescreening. The optimal time lag before such controls should be performed is, however, not yet determined.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, in one study nondetectable levels of the drug were found in the morning of the ® fth day after start of such a therapy. Persistence of C. trachomatis in tubal tissue may occur in spite of repeated courses of tetracycline given to cases with chronic tubal infection 9,10 . Such an infection may be detectable by immunohistological staining of tissue sections, but may be undetectable by culture and/or PCR/LCR tests.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Is there a need for rescreening of patients treated for genital chlamydial infections?

Mårdh

Persson

2002

Int J STD AIDS

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Summary:The present communication reviews reasons to perform rescreening of chlamydia-infected persons. It brings up dif® culties to differentiate between relapse and reinfection. Studies on follow-up of chlamydia-positive cases after therapy are reviewed. It also highlights reasons for therapeutic failure, like compliance, pharmacological factors, including poor bioavailability, wrong dose regimens, lack of adherence to drug intake, neglect of partner noti® cation and concomitant therapy in consorts, possible development of resistance to drugs generally prescribed, false negative or false positive diagnostic tests and reinfection from extra-genital not`cured' sites. The review points to the need to establish programmes for routine rescreening of chlamydia-infected persons.

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“…It has been shown that C. trachomatis infection in monkeys induced delayed hypersensitivity, which is proposed to be the pathogenic mechanism of tubal damage in this species (Patton et al, 1994). There have been reports of serologic evidence of past chlamydial infections (Ness and Brooks-Nelson, 1999;Patton et al, 1994b;Robertson et al, 1987) in women with tubal infertility, and it has been reported that interleukin-1 (IL-1) initiates Fallopian tube destruction following a C. trachomatis infection (Hvid et al, 2007). In a retrospective study of 84 infertile women with tubal occlusion, the sera collected from 28% of these women were positive for chlamydial anti-IgG antibody, compared to only 11% positivity to the chlamydial anti-IgG antibody in sera collected from 253 infertile controls (Merki-Feld et al, 2007).…”

Section: Chlamydia Tubal Pathology and Tubal Factor Infertilitymentioning

confidence: 99%