Detection of Carotid Artery Plaque Ulceration Using 3-Dimensional Ultrasound

Heliopoulos, John; Vadikolias, Κonstantinos; Piperidou, Charitomeni; Mitsias, Panayiotis

doi:10.1111/j.1552-6569.2009.00450.x

Cited by 43 publications

(48 citation statements)

References 44 publications

(79 reference statements)

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“…29 The application of color-flow Doppler-assisted duplex imaging, which combines the B-mode and blood-flow velocity information, 32 also shows limitations in providing adequate information to identify plaque ulcerations. 31,33 Second, the intrareader reproducibility of both Bmode and Doppler sonography is low ( ranges from 0.11 to 0.89 31,[34][35][36] ), which is not sufficient for reliable diagnosis.…”

Section: Sonographymentioning

confidence: 99%

“…36,42 3D sonographic images can be obtained by using dedicated 3D probes or by using 2D sonographic probes with the help of positioning sensors and postreconstruction algorithms to combine 2D sections into a 3D volume. 43,44 This process improves image quality, provides more information about plaque morphology and echomorphology, and has been used to noninvasively quantify plaque stenosis 45 and volume 46,47 and examine the regression and progression of plaque ulceration.…”

mentioning

confidence: 99%

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Imaging Carotid Atherosclerosis Plaque Ulceration: Comparison of Advanced Imaging Modalities and Recent Developments

Yuan

Usman

Das

et al. 2016

AJNR Am J Neuroradiol

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SUMMARY: Atherosclerosis remains the leading cause of long-term mortality and morbidity worldwide, despite remarkable advancement in its management. Vulnerable atherosclerotic plaques are principally responsible for thromboembolic events in various arterial territories such as carotid, coronary, and lower limb vessels. Carotid plaque ulceration is one of the key features associated with plaque vulnerability and is considered a notable indicator of previous plaque rupture and possible future cerebrovascular events. Multiple imaging modalities have been used to assess the degree of carotid plaque ulceration for diagnostic and research purposes. Early diagnosis and management of carotid artery disease could prevent further cerebrovascular events. In this review, we highlight the merits and limitations of various imaging techniques for identifying plaque ulceration.ABBREVIATIONS: CE-MRA ϭ contrast-enhanced MRA; CDUS ϭ color Doppler ultrasound; CEUS ϭ contrast-enhanced ultrasound; US ϭ ultrasound; XRA ϭ x-ray

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Section: Sonographymentioning

confidence: 99%

mentioning

confidence: 99%

Imaging Carotid Atherosclerosis Plaque Ulceration: Comparison of Advanced Imaging Modalities and Recent Developments

Yuan

Usman

Das

et al. 2016

AJNR Am J Neuroradiol

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“…The sensitivity and specificity of the DU on detecting ulceration have improved over the years 36,38,39 . Both B-mode imaging and flow disturbance originated by ulceration can be used to identify surface abnormalities on DU [42][43][44] . The improvement of ultrasound imaging and possibility of 3D format certainly will assist in increasing the likelihood of ulcer detection.…”

Section: Surfacementioning

confidence: 99%

“…42 . A high-resolution MR imaging and a multi-detector CT angiography have also shown very good results of ulceration detection 40,45 .…”

Section: Surfacementioning

confidence: 99%

“…Frequently, the method used in CT and MRI is the demarcation of the regions of interest in multiple planes generating the area of the plaque that is added together creating a 3D image [68][69][70] . The ultrasonic assessment of the plaque volume is achieved using a real-time cine-loop recording application, which utilizes the sequential 2D gray scale imaging 42 . The gender differences related to the plaque volume was evaluated in a study with 131 asymptomatic carotid plaques using a 3.0-Tesla, which showed that an increased volume of lipid-rich necrotic core (LRNC) is more prevalent in men 70 .…”

Section: Volumementioning

confidence: 99%

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Stratifying risk: asymptomatic carotid disease

et al. 2012

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Stroke generates significant healthcare expenses and it is also a social and economic burden. The carotid artery atherosclerotic plaque instability is responsible for a third of all embolic strokes. The degree of stenosis has been deliberately used to justify carotid artery interventions in thousands of patients worldwide. However, the annual risk of stroke in asymptomatic carotid artery disease is low. Plaque morphology and its kinetics have gained ground to explain cerebrovascular and retinal embolic events. This review provides the readers with an insightful and critical analysis of the risk stratification of asymptomatic carotid artery disease in order to assist in selecting potential candidates for a carotid intervention.

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Noninvasive atherosclerosis imaging modalities and their application to investigating cardiovascular drug effects in rheumatoid arthritis

Furer

Fayad

Farkouh

et al. 2011

Drug Development Research

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Rheumatoid arthritis (RA) is a systemic inflammatory disorder that affects not only joints but also the cardiovascular (CV) system. Premature endothelial dysfunction and accelerated atherosclerosis are pertinent findings in patients with RA, resulting in increased CV morbidity and mortality. Thus, detection of subclinical atherosclerosis is important in RA management. A range of promising imaging modalities is currently available to visualize early vascular disease and monitor changes in atherosclerotic plaque burden, serving as important tools in CV risk stratifications and as surrogate markers for CV endpoints in intervention trials. This review summarizes various noninvasive imaging modalities, implemented in widespread clinical use, such as vascular ultrasonography and cardiac computer tomography, as well as novel emerging technologies, such as magnetic resonance imaging and positron emission tomography. These novel technologies make a step forward in the evaluation and quantification of atherosclerotic plaque features, permitting the detection of vulnerable plaque as well as functional assessment of vessel wall metabolic activity that was previously not achievable. Application of the imaging modalities to monitor CV drug effects in therapeutic clinical trials in both the general and RA population is further presented and discussed. Drug Dev Res 72:739-749,

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Detection of Carotid Artery Plaque Ulceration Using 3-Dimensional Ultrasound

Abstract: 3D ultrasound reliably characterized the surface morphology of atherosclerotic carotid plaques. A trend of superiority of 3D ultrasound over 2D was found in detecting ulcers of carotid artery plaque.

Cited by 43 publications

References 44 publications

Imaging Carotid Atherosclerosis Plaque Ulceration: Comparison of Advanced Imaging Modalities and Recent Developments

Imaging Carotid Atherosclerosis Plaque Ulceration: Comparison of Advanced Imaging Modalities and Recent Developments

Stratifying risk: asymptomatic carotid disease

Noninvasive atherosclerosis imaging modalities and their application to investigating cardiovascular drug effects in rheumatoid arthritis

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