Detection of Cancer through Nano Amperometric Biosensor by Viscosity

Abstract

Biosensors are invented by Lenard C. Clarke in 1962 to perform experiments on Bio electric potentials. It consists of 3 electrodes namely, Working electrode, Reference electrode and Counter Electrode. Working electrode is made of Glassy carbon and Stainless steel. Reference electrode is made of Silver or Silver chloride; Counter electrode is made of platinum. The substrate is made of glass. The solution that is poured into the biosensor is called Analyte. It is otherwise called Bulk solution. When substrate appears in Bulk Solution, the operation of biosensor takes place. Michaels Manton equations are taken into consideration for illustration of basic working of Biosensor. The basic biosensor contains a Ligand and a transducer. The ligand is biological element in which I used is GODX chemical (Glucose Oxidase), and Transducer is one which converts one form of energy to another form. The output of Transducer is electrical signal. The Viscosity which is Applied Physics Variable is used in detection of Cancer Pathogen. Viscosity [1] is defined as ratio of shear stress to velocity gradient in a fluid. It plays a key role in detection of cancer pathogen in a blood sample. Viscosity variables are simulated in MATLAB software and numerical simulation is performed and from the output graphs, it is found that Viscosity is high for Non-Cancerous cells and low for cancerous samples.