Detection of cancer biomarkers by piezoelectric biosensor using PZT ceramic resonator as the transducer

Recent advances in biosensor development for the detection of cancer biomarkers

“…Another label-free piezoelectric biosensor is reported by Su et al (2013) for the detection of PSA and AFP. Here, antibodies of AFP and PSA are immobilized on lead titanate zirconite (PZT) ceramic resonator transducers.…”

Molecular biosensors: promising new tools for early detection of cancer

“…The results confirmed that this ceramic resonator-based piezoelectric biosensor could be used with different chemical interfaces, and the small size of the resonators provides an opportunity to fabricate sensor arrays for multiplex detection, which is crucial in the precise diagnosis of cancer cases. 66 Furthermore, bioassays measuring the activity or presence of target cancer biomarker molecules through molecular sensing systems enable more sensitive and rapid detection when nanomaterials are used as signal amplifiers or tags. 48 Magnetic-based immunoassay techniques have been developed in which target analyte molecules or microorganisms can be labeled with magnetic nanoparticles via an appropriate antibody.…”

The Emergence of Interdisciplinary Research in Cancer Diagnostics

“…The target is selectively attached to the resonator using a ligand (antibody or aptamer). The sensing signal is measured in terms of the resonance frequency of the piezoelectric crystal [30,31]. Thermal technique is probably the least sought approach in cancer detection.…”