Detection of bronchioloalveolar cancer by means of PET/CT and 18F-fluorocholine, and comparison with 18F-fluorodeoxyglucose

Balogova, Sona; Huchet, Virginie; Kerrou, Khaldoun; Nataf, Valérie; Gutman, Fabrice; Antoine, Martine; Ruppert, Anne-Marie; Prignon, Aurélie; Lavolée, Armelle; Montravers, F.; Mayaud, C; Cadranel, J.; Talbot, Jean-Noël

doi:10.1097/mnm.0b013e3283369654

Cited by 45 publications

(21 citation statements)

References 15 publications

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“…Globally, the uptake of radiolabeled choline in malignant tumors could be due to the highest synthesis of cell membrane induced by the faster mitosis of cellular types expressing an high rate of replication, as known for malignant tumors, hepato-cellular (51) and bronchiolo-alveolar carcinoma (21).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…All these experiences probably contributed to develop new clinical applications for radiolabeled choline PET/CT; some recently published papers investigate the possible role of this tracer in imaging brain tumors (BT) (17,18), parathyroid adenomas (19) and urothelial carcinoma (20). In fact, the uptake of radiolabeled choline can provide important information about the extension and growth of tumors (21) or inflammation (22).…”

Section: Introductionmentioning

confidence: 99%

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PET/CT with 18 F–choline: Physiological whole bio-distribution in male and female subjects and diagnostic pitfalls on 1000 prostate cancer patients

Calabria

Chiaravalloti

Cicciò

et al. 2017

Nuclear Medicine and Biology

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PET/CT with 18 F–choline: Physiological whole bio-distribution in male and female subjects and diagnostic pitfalls on 1000 prostate cancer patients

Calabria

Chiaravalloti

Cicciò

et al. 2017

Nuclear Medicine and Biology

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“…However the most common limits of this technique are represented by well-differentiated cancer forms and in general tumors with low proliferative index [6, 7]. Bronchioloalveolar lung adenocarcinoma or clear cell tumor of the kidney is the most common example of low neoplastic uptake of 18 F-FDG [8].…”

Section: Discussionmentioning

confidence: 99%

PET/CT Imaging in Oncology: Exceptions That Prove the Rule

Casali

Froio

Carbonelli

et al. 2013

Case Reports in Oncological Medicine

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18F-FDG PET/CT is a diagnostic three-dimensional non-invasive device, routinely employed in neurology, cardiology, and oncology, and which contributes to patient care giving functional informations about glucose metabolism. In particular, staging, restaging, follow-up and response to treatment of tumors are the most common applications in oncologic field. Many neoplasms show increased glucose metabolism and consequent 18F-FDG uptake. Nevertheless, some relative differentiated cancers, such as clear cell carcinoma of the kidney and bronchioloalveolar adenocarcinoma, show tipically faintly/no uptake resulting in a consequent negative PET/CT scan. This case report represents an extreme case in which three relative well-differentiated cancer forms, all characterized by low glucose metabolism, affect the same patient at the same time while 18F-FDG PET/CT scan is negative.

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“…Several studies have been performed using radiopharmaceuticals that follow the lipid metabolism, such as 11 C or 18 F-choline (30–32). Choline is an essential component of the phospholipids in the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

Clinical importance of [18F]fluorodeoxyglucose positron emission tomography/computed tomography in the management of patients with bronchoalveolar carcinoma: Role in the detection of recurrence

et al. 2013

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[18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been reported to have a low sensitivity in the initial diagnosis of bronchoalveolar carcinoma (BAC) due to BAC’s low metabolic activity. The aim of this study was to assess the value of [18F]FDG-PET/CT in the detection of BAC recurrence. Between February 2007 and September 2011, the [18F]FDG-PET/CT scans that were performed on patients with known, histologically proven BAC were studied. A total of 24 [18F]FDG-PET/CT scans were performed in 22 patients, including 16 males and 6 females, with a mean age of 65±9 years. Among the scans, 15 were performed to assess for possible recurrence with equivocal findings in conventional imaging methods and 9 for restaging post-therapy. In all cases conventional imaging studies (CT and MRI) were performed 5–30 days prior to PET/CT. Among the 24 [18F]FDG-PET/CT scans, 18 were positive and 6 negative. Among the 15 [18F]FDG-PET/CT scans performed for suspected recurrence, 34 lesions were detected and the mean maximum standardized uptake value (SUVmax) was 6.8±3.26. In nine scans, upstaging was observed, while two were in agreement with the findings of the conventional modalities. A greater number of lesions were detected in two scans and fewer lesions were detected in one, with no change in staging. Only one scan was negative. By contrast, in patients examined for restaging, there were only five lesions with a mean SUVmax of 4.86±3.18. Agreement between the findings of [18F]FDG-PET/CT and the conventional modalities was observed in 8 out of 9 cases. Although [18F]FDG-PET/CT has been reported to have a low sensitivity in the initial diagnosis of BAC, the present results indicate that when there is recurrence, the lesions become [18F]FDG avid. [18F]FDG-PET/CT may provide further information in patients evaluated for recurrence and thus improve patient management.

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Detection of bronchioloalveolar cancer by means of PET/CT and 18F-fluorocholine, and comparison with 18F-fluorodeoxyglucose

Abstract: In this population of patients with ground-glass opacities selected on CT suggestive of BAC or with a history of BAC and a recent lung anomaly on CT, FCH detected all malignant lesions with at least a 2.0 cm short axis. However, FDG had similar performance.

Cited by 45 publications

References 15 publications

PET/CT with 18 F–choline: Physiological whole bio-distribution in male and female subjects and diagnostic pitfalls on 1000 prostate cancer patients

PET/CT with 18 F–choline: Physiological whole bio-distribution in male and female subjects and diagnostic pitfalls on 1000 prostate cancer patients

PET/CT Imaging in Oncology: Exceptions That Prove the Rule

Clinical importance of [18F]fluorodeoxyglucose positron emission tomography/computed tomography in the management of patients with bronchoalveolar carcinoma: Role in the detection of recurrence

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