Detection of bio-organism simulants using random binding on a defect-free photonic crystal

Abstract

The defect-free photonic crystal (PC) slab geometry was explored for size-selective detection of bio-organism simulants. Through feedback between finite-difference time-domain simulations and experiments, we generated a conservative limit of detection estimate for randomized pore filling of a two-dimensional PC slab, and predict that random binding affords the label-free PC-based optical detection of low numbers (of the order of 10) of biological particles.

Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing

“…Baker et al utilized a defect-free slab-PhC design to demonstrate size-selective detection of latex particles. 67 In their experiments, the infiltration of latex particles with diameters of 260 and 320 nm within the PhC lattice holes of 280 nm in diameter was investigated. A significant red-shift in the band-edge of the crystal was observed for the infiltration of smaller particles, thus demonstrating size selective particle detection.…”

Real‐Time Template‐Assisted Manipulation of Nanoparticles in a Multilayer Nanofluidic Chip

“…The functionality of the assembled structure depends on the designed nanochannel pattern and its effective index of refraction as determined by the size of the nanochannels, the nanoparticle's properties, such as its index of refraction, and the depth to which the nanoparticles are trapped in the nanochannels. For example, the transmission peak would shift when nanoparticles are captured onto the nanochannels, analogous to a recent paper that used photonic crystals for detection of bioorganism simulants 23…”

Ultra-sensitive and dual-polarization refractive-index biosensors based on annular photonic crystals

“…Another crucial feature of PCs for bio-sensing application is their compact structure and natural micro channels that make them to be an ideal platform for microfluidic or optofluidic lab-on-chip technologies [18,21]. The PCs-based biosensors can be further divided into four sub types, i.e., one-dimensional (1D) PCs biosensors [9,10], two-dimensional (2D) PCs biosensors [11][12][13][14][15][16][17][18], three-dimensional (3D) PCs biosensors [19], and photonic crystal fiber biosensors [20]. However, as compared to SPR biosensors, the RI sensitivity and DL of PCs biosensors are still not satisfactory.…”