Detection of articular cartilage lesions: Experimental evaluation of low- and high-field-strength MR imaging at 0.18 and 1.0 T

Woertler, Klaus; Strothmann, Marc; Tombach, Bernd; Reimer, Peter

doi:10.1002/1522-2586(200006)11:6<678::aid-jmri15>3.0.co;2-y

Cited by 71 publications

(58 citation statements)

References 36 publications

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“…One of the requirements for reliable assessment of cartilage pathology is therefore the use of high-field systems with !1.0 T (32). These are usually whole-body 1.5 T magnets [ Fig.…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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“…One of the requirements for reliable assessment of cartilage pathology is therefore the use of high-field systems with !1.0 T (32). These are usually whole-body 1.5 T magnets [ Fig.…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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“…A recent study shows that low-field dedicated extremity MRI can provide similar information on bone erosions and synovitis as expensive high-field MRI units [6]. There have been several comparisons of diagnostic performance of diagnosing meniscal tears, cruciate ligaments, and cartilage lesions between low-field and high-field MRI data [7]- [9] reporting everything from compatible performance to the high-field unit outperforming the low-field unit. There has also been a comparison between lowfield MRI and arthroscopy [10] finding a good correspondence between the two for cruciate ligament and lesion detection in the knee.…”

Section: Introductionmentioning

confidence: 99%

Segmenting Articular Cartilage Automatically Using a Voxel Classification Approach

Folkesson

Dam

Olsen

et al. 2007

IEEE Trans. Med. Imaging

166

159

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Abstract-We present a fully automatic method for articular cartilage segmentation from magnetic resonance imaging (MRI) which we use as the foundation of a quantitative cartilage assessment. We evaluate our method by comparisons to manual segmentations by a radiologist and by examining the interscan reproducibility of the volume and area estimates. Training and evaluation of the method is performed on a data set consisting of 139 scans of knees with a status ranging from healthy to severely osteoarthritic. This is, to our knowledge, the only fully automatic cartilage segmentation method that has good agreement with manual segmentations, an interscan reproducibility as good as that of a human expert, and enables the separation between healthy and osteoarthritic populations. While high-field scanners offer high-quality imaging from which the articular cartilage have been evaluated extensively using manual and automated image analysis techniques, low-field scanners on the other hand produce lower quality images but to a fraction of the cost of their high-field counterpart. For low-field MRI, there is no well-established accuracy validation for quantitative cartilage estimates, but we show that differences between healthy and osteoarthritic populations are statistically significant using our cartilage volume and surface area estimates, which suggests that low-field MRI analysis can become a useful, affordable tool in clinical studies.

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“…In der Praxis hat sich die Niederfeld-MRT bei der Abklärung verschiedener Knochen-, Band-und Sehnenpathologien peripherer Gelenke bereits bewährt [2,4,5]. Für die kontrastreiche Darstellung des hyalinen Gelenkknorpels an Niederfeldgeräten werden T 1 -gewichtete Gradientenecho-Sequenzen empfohlen [7,11]. An Hochfeld-Systemen ist ein höheres Signal-RauschVerhältnis und damit eine bessere Detailerkennbarkeit zu erzielen.…”

Section: Diskussionunclassified

“…An Hochfeld-Systemen ist ein höheres Signal-RauschVerhältnis und damit eine bessere Detailerkennbarkeit zu erzielen. In Verbindung mit der frequenzselektiven Fettsät-tigung kann auch der Kontrast zu den umgebenden Strukturen optimiert werden [11]. Dennoch bleibt die Beurteilung des Gelenkknorpels bei der ODT problematisch.…”

Section: Diskussionunclassified

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Nachweis einer radiographisch okkulten Osteochondrosis dissecans tali mit der MRT

Wirth¹,

Wieser²,

Witt³

et al. 2003

Der Unfallchirurg

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Posttraumatic disorders of the ankle are a common cause of chronic pain. Magnetic resonance imaging (MRI) has proved to be highly useful in clarifying a wide spectrum of underlying lesions which frequently cannot be detected on radiographs. Even if the assessment of the lateral collateral ligaments of the ankle is not regarded as a primary indication for MRI, it allows the diagnosis of subchondral contusions or cysts, anterolateral impingement syndrome, sinus tarsi syndrome, osteochondral fractures and osteochondrosis dissecans of the talus (ODT),which may not be detected with other imaging modalities. A 42 year old female patient suffered from persisting non-specific pain following an inversion trauma 4 months previously. MRI enabled the detection of an ODT which was not diagnosed on plain radiographs and which was verified upon arthroscopy. A superficial cartilage defect, as shown arthroscopically,was not delineated using MRI. Our observations indicate that MRI may be useful in patients with unclear persisting pain following ankle trauma and that it may contribute to the early detection of lesions which require surgical intervention.

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Detection of articular cartilage lesions: Experimental evaluation of low- and high-field-strength MR imaging at 0.18 and 1.0 T

Cited by 71 publications

References 36 publications

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Segmenting Articular Cartilage Automatically Using a Voxel Classification Approach

Nachweis einer radiographisch okkulten Osteochondrosis dissecans tali mit der MRT

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