Detection of antibody-antigen reaction by silicon nitride slot-ring biosensors using protein G

Taniguchi, Tomoya; Hirowatari, Anna; Ikeda, Takeshi; Fukuyama, Masafumi; Amemiya, Yoshihito; Kuroda, Akio; Yokoyama, Shiyoshi

doi:10.1016/j.optcom.2015.11.068

Cited by 51 publications

(35 citation statements)

References 32 publications

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“…Despite wide use of antibodies [4][5][6], they still suffer from chemical instability, synthesis difficulty, large size, and high cost. Aptamers, single-stranded RNA or DNA oligonucleotide selected by the systematic evolution of ligands by exponential enrichment (SELEX) methodology, interact with targets by forming special three-dimensional conformations.…”

Section: Introductionmentioning

confidence: 99%

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Zhao

Zhang

Wei

et al. 2017

Biomed. Opt. Express

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Abstract:The aptamer and target molecule binding reaction has been widely applied for construction of aptasensors, most of which are labeled methods. In contrast, terahertz technology proves to be a label-free sensing tool for biomedical applications. We utilize terahertz absorption spectroscopy and molecular dynamics simulation to investigate the variation of binding-induced collective vibration of hydrogen bond network in a mixed solution of MUC1 peptide and anti-MUC1 aptamer. The results show that binding-induced alterations of hydrogen bond numbers could be sensitively reflected by the variation of terahertz absorption coefficients of the mixed solution in a customized fluidic chip. The minimal detectable concentration is determined as 1 pmol/μL, which is approximately equal to the optimal immobilized concentration of aptasensors. 575-579 (2012). 33. J.-J. Max and C. Chapados, "IR spectroscopy of aqueous alkali halide solutions: pure salt-solvated water spectra and hydration numbers," J.

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Section: Introductionmentioning

confidence: 99%

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Zhao

Zhang

Wei

et al. 2017

Biomed. Opt. Express

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“…The sensor operated at 1.3 µm and achieved a bulk sensitivity of 212 nm/RIU and a bulk sLoD of 2 × 10 −4 RIU. Afterward, numerous MRR sensors with the slot waveguide design have been reported [76][77][78]. Zhang et al [79] investigated a new approach for RI sensing using SOI slot waveguide racetrack resonators.…”

Section: Slot Waveguidementioning

confidence: 99%

Progress of infrared guided-wave nanophotonic sensors and devices

Dong

Lee

2020

Nano Convergence

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Nanophotonics, manipulating light-matter interactions at the nanoscale, is an appealing technology for diversified biochemical and physical sensing applications. Guided-wave nanophotonics paves the way to miniaturize the sensors and realize on-chip integration of various photonic components, so as to realize chip-scale sensing systems for the future realization of the Internet of Things which requires the deployment of numerous sensor nodes. Starting from the popular CMOS-compatible silicon nanophotonics in the infrared, many infrared guided-wave nanophotonic sensors have been developed, showing the advantages of high sensitivity, low limit of detection, low crosstalk, strong detection multiplexing capability, immunity to electromagnetic interference, small footprint and low cost. In this review, we provide an overview of the recent progress of research on infrared guided-wave nanophotonic sensors. The sensor configurations, sensing mechanisms, sensing performances, performance improvement strategies, and system integrations are described. Future development directions are also proposed to overcome current technological obstacles toward industrialization.

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“…With respect to the system in which WGM resonators are equipped, advances such as transduction and data-processing or filtering techniques [ 21 ], dynamic referencing [ 111 ], surface functionalization [ 112 , 113 , 114 ], and the integration of microfluidics have been reported. Many WGMs are integrated into microfluidic chips to streamline testing with a small sample volume [ 104 ].…”

Section: Whispering Gallery Mode (Wgm)-based Biosensorsmentioning

confidence: 99%

Label-Free Optical Resonator-Based Biosensors

Rho

Breaux

Kim

2020

Sensors

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The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising platform not only for general medical diagnostics but also for point-of-care applications. This review aims to provide an overview of recent progresses in label-free optical resonator-based biosensors published mostly over the last 5 years. We categorized them into Fabry-Perot interferometer-based and whispering gallery mode-based biosensors. The principles behind each biosensor are concisely introduced, and recent progresses in configurations, materials, test setup, and light confinement methods are described. Finally, the current challenges and future research topics of the optical resonator-based biosensor are discussed.

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Detection of antibody-antigen reaction by silicon nitride slot-ring biosensors using protein G

Cited by 51 publications

References 32 publications

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Progress of infrared guided-wave nanophotonic sensors and devices

Label-Free Optical Resonator-Based Biosensors

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