Detection of anti-diabetics in equine plasma and urine by liquid chromatography?tandem mass spectrometry

Disorders of glucose metabolism–post mortem analyses in forensic cases: part I

“…To our knowledge, the inclusion of all oral antidiabetics in one analytical procedure was only described twice, meaning LC-MS/MS methods for the determination of sulfonylureas, glinides, and glitazones in equine plasma [100] and in human urine [101]. Recently, such a method to determine all of the oral antidiabetics in human serum has been submitted by us also [102].…”

Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs

“…Several analytical methods have been reported for the detection of anti-diabetic drugs in plasma or urine, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) [6,7], high performance liquid chromatography (HPLC) with ultraviolet (UV) [8][9]. Ho et al [6] developed an LC-MS/MS for simultaneous detection of 10 anti-diabetics in equine plasma and urine.…”

Solving signal instability to maintain the second-order advantage in the resolution and determination of multi-analytes in complex systems by modeling liquid chromatography–mass spectrometry data using alternating trilinear decomposition method assisted with piecewise direct standardization

“…However, most oral antidiabetics can cause life-threatening hypoglycaemias and can therefore be misused with suicidal or homicidal intent [60][61][62]. Besides, SOADs can be also used as a stopper in racehorses by reducing the blood glucose level [63]. Therefore, rapid screening for multiple antidiabetic agents in a single analysis has been of significant importance in clinical and forensic toxicology, and anti-doping control.…”