Detection of angiographically significant coronary artery disease with accelerated intermittent imaging after intravenous administration of ultrasound contrast material

Incremental Benefit of Myocardial Contrast to Combined Dipyridamole-Exercise Stress Echocardiography for the Assessment of Coronary Artery Disease

“…[5][6][7] However, the presence and extent of CAD at coronary angiography have traditionally been used as the reference standard for the assessment of CAD. Limited comparative data 6,7,20,[23][24][25] have been obtained between MCE and angiography (Table 3). In 45 patients undergoing mainly dobutamine stress echocardiography, Cwajg et al 23 showed a greater sensitivity for real-time, contrast-enhanced than for standard stress echocardiography (87% versus 56%) and a better recognition of disease extent by MCE (85% versus 39%).…”

“…Limited comparative data 6,7,20,[23][24][25] have been obtained between MCE and angiography (Table 3). In 45 patients undergoing mainly dobutamine stress echocardiography, Cwajg et al 23 showed a greater sensitivity for real-time, contrast-enhanced than for standard stress echocardiography (87% versus 56%) and a better recognition of disease extent by MCE (85% versus 39%). These results were surprisingly unfavorable for standard imaging, perhaps reflecting the limitations of lower-frame-rate, real-time imaging.…”

Impact of previous myocardial infarction on the incremental value of myocardial contrast to two-dimensional supine bicycle stress echocardiography in evaluation of coronary artery disease

“…Experimental and clinical studies have shown that when compared with WMAs, perfusion defects occur earlier, require a lower stress threshold to occur, and affect a greater myocardial area [5,7,8,[10][11][12][13]. In our study, the incremental value of MCE was especially evident in patients with SVD or 50-69% stenosis.…”

“…It has been demonstrated that MCE not only closely agrees with single photon emission computed tomography (SPECT) [2,3] and positronemission tomography [4] but also enhances sensitivity of two-dimensional echocardiography (2DE) to detect obstructive International Journal of Cardiology 136 (2009) 47 -55 www.elsevier.com/locate/ijcard coronary artery disease (CAD) [5][6][7][8][9]. This higher incremental value of MCE over 2DE is explained by the discrepancy between perfusion and wall motion abnormalities (WMAs) in the ischemic cascade [5,7,8,[10][11][12][13].…”

Myocardial Perfusion Imaging Using Contrast Echocardiography

“…Almost all the questions addressed with catheter-administered contrast have been examined using a variety of pervenous agents. The results have clearly demonstrated that pervenous contrast agents are capable of providing perfusion abnormalities in various ischemic syndromes [6,18,[34][35][36] (Figure 1). …”