Myocardial Perfusion Imaging Using Contrast Echocardiography

Nesser, H. Joachim; Morcerf, Fernando; Teupe, Claudius; Pandian, Natesa G.

doi:10.1007/s00059-002-2375-6

Herz

2002

DOI: 10.1007/s00059-002-2375-6

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Myocardial Perfusion Imaging Using Contrast Echocardiography

H. Joachim Nesser

Fernando Morcerf

Claudius Teupe

et al.

Abstract: The technique continues to evolve from intermittent gated examination to real-time perfusion imaging that allows evaluation of both perfusion and functional parameters. The opportunity to target sites of pathology with specially engineered microbubbles could also aid in many therapeutic applications besides diagnostic imaging.

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Cited by 3 publications

References 36 publications

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Resting Myocardial Contrast Echocardiography for the Evaluation of Coronary Microcirculation Dysfunction in Patients With Early Coronary Artery Disease

Sheng

Zhang

et al. 2016

Clinical Cardiology

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Background: Coronary microcirculation dysfunction can occur in patients with chest pain suggestive of coronary artery disease (CAD). The present study aimed to determine the diagnostic value of resting myocardial contrast echocardiography (MCE) for early CAD with myocardial microcirculation dysfunction by evaluating the continuous imaging time, peak time, and peak intensity. Hypothesis: Resting MCE is an effective and noninvasive method for evaluation of coronary microcirculation dysfunction in patients with early coronary artery disease. Methods:The present study included 20 consecutive patients without obvious clinical evidence of early CAD and 20 healthy volunteers. Resting MCE was performed to evaluate the myocardial microcirculation perfusion, and the follow-up evaluation of myocardial microcirculation perfusion was performed with technetium 99 m 2-methoxy-isobutyl-isonitrile ( 99m Tc-MIBI) single-photon emission computed tomography (SPECT).Results: Peak intensity was significantly lower in patients with high risk of CAD than in controls (P < 0.0001).The peak time and continuous imaging time were significantly higher in patients with high risk of CAD than in controls (P < 0.0001). None of the 40 subjects experienced discomfort, such as cough and chest tightness, during the resting MCE procedure, and the heart rate and blood pressure showed no abnormalities during the entire procedure. SPECT imaging showed reversible myocardial perfusion reduction in 80% (16/20) of the patients with high risk of CAD. Abnormalities of heart rate and blood pressure and adverse reactions were noted during the process of SPECT examination. Conclusions:Resting MCE is an effective and noninvasive method for detecting abnormalities of coronary microcirculation and can help in the clinical analysis, risk assessment, and treatment of early occult CAD.

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Resting Myocardial Contrast Echocardiography for the Evaluation of Coronary Microcirculation Dysfunction in Patients With Early Coronary Artery Disease

Sheng

Zhang

et al. 2016

Clinical Cardiology

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Real-Time Myocardial Contrast Echocardiography in Rat: Infusion Versus Bolus Administration

Qian

Wei

et al. 2009

Ultrasound in Medicine & Biology

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BR38, a New Ultrasound Blood Pool Agent

Schneider

Anantharam²,

Arditi³

et al. 2011

Investigative Radiology

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Myocardial Perfusion Imaging Using Contrast Echocardiography

Cited by 3 publications

References 36 publications

Resting Myocardial Contrast Echocardiography for the Evaluation of Coronary Microcirculation Dysfunction in Patients With Early Coronary Artery Disease

Resting Myocardial Contrast Echocardiography for the Evaluation of Coronary Microcirculation Dysfunction in Patients With Early Coronary Artery Disease

Real-Time Myocardial Contrast Echocardiography in Rat: Infusion Versus Bolus Administration

BR38, a New Ultrasound Blood Pool Agent

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