2003
DOI: 10.1111/j.1523-5378.2003.00186.x
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Detection of a Putative Novel Wolinella Species in Patients with Squamous Cell Carcinoma of the Esophagus

Abstract: Helicobacteraceae were detected in approximately 50% of South African patients with esophageal carcinoma. Furthermore, a novel bacterium was identified that might be linked to the enhanced incidence of esophagitis and subsequent malignant disease in South Africa.

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Cited by 24 publications
(24 citation statements)
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“…DNA sequencing and consecutive biocomputing were performed as previously described (1,3). RFLP analysis was performed using restriction enzymes BfaI and BstUI.…”
mentioning
confidence: 99%
“…DNA sequencing and consecutive biocomputing were performed as previously described (1,3). RFLP analysis was performed using restriction enzymes BfaI and BstUI.…”
mentioning
confidence: 99%
“…Biopsy specimens from the terminal ileum and the colon of each patient were analyzed by a group-specific PCR assay with primers C97 (5Ј-GCTATGACGGGTATCC-3Ј) and H2 (5Ј-TCGCAATGAGTATTCCTCTT-3Ј) as previously described (2,3). In order to identify the Helicobacter species, amplification products were sequenced as described before (3).…”
mentioning
confidence: 99%
“…In order to identify the Helicobacter species, amplification products were sequenced as described before (3).…”
mentioning
confidence: 99%
“…While such organisms (as previously stated) are morphologically consistent with the genus Helicobacter (26), it is surprising that given the large numbers of these organisms, a sequence similar to that of Wolinella was recovered. Despite the fact that only one species (W. succinogenes) has been described to date, another putative novel species (namely, "Candidatus W. africanus") was recently detected by PCR in patients with esophageal carcinoma (3). Given the substantial difference in nucleotide sequence (approximately 7 to 12%) from more than 40 Helicobacter and Campylobacter sequences, it is likely that this sequence represents a novel species.…”
Section: Discussionmentioning
confidence: 99%
“…Despite this limitation, its detection in the gut of this host, given the ability of other species to cause similar conditions of disease in other marine mammals (16,17), is novel and reflects the potential for multiple genera of the family Helicobacteraceae to infect this host. Coinfection of a host by closely related taxa has some precedence in the literature and has been reported for Campylobacter, Helicobacter, and Wolinella species (3,24). While any of these species may have been responsible for the development of gastritis in this animal, they also may have been mere bystanders (3), as species of Helicobacter, like those of Wolinella, may be nonpathogenic in their natural host (25,26).…”
Section: Discussionmentioning
confidence: 99%