Detection and Typing of Human Papillomavirus in Verrucous Carcinoma of the Oral Cavity Using the Polymerase Chain Reaction

Noble-Topham, S E; Fliss, Dan M.; Hartwick, R. W. J.; McLachlin, C. Meg; Freeman, Jeremy L.; Noyek, Arnold M.; Andrulis, IL

doi:10.1001/archotol.1993.01880240033005

Cited by 37 publications

(27 citation statements)

References 50 publications

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“…Specifically, HPV 6b/11 DNA, HPV 16 DNA, hPV 18 DNA, and hPV 16 DNA plus hPV 18 DNA were detected in one (4%), one (4%), nine (36%), and one (4%) cases, respectively. The detection of hPV 18 DNA in 40% of OVCs reveals an association between hPV and OVC although the potential etiologic and prognostic significance of HPV in OVC deserves further exploration (34). On the contrary, other scholars argued that the role of hPV might be occasional as there was no verified correlation between OVC and HPV in their work (36)(37)(38).…”

Section: Etiologymentioning

confidence: 94%

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Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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Section: Etiologymentioning

confidence: 94%

“…Some researchers considered that hPV was a possible pathogeny of OVC (32)(33)(34)(35). NobleTopham et al reported the detection of hPV DNA in 12 (48%) of 25 OVC patients.…”

Section: Etiologymentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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“…The presence of HPV in verrucous carcinomas has been analyzed by several authors [3,4,33,42,43,46,49,62] with the detection rate of 37.7% (60/159; range 0-100%) (summarized in [68]). Interestingly, the most prevalent HPV type was HPV 6/11 (47%), followed by HPV 16/18 (35.3%) and HPV 2 (17.7%).…”

Section: Hpv and Verrucous Carcinomamentioning

confidence: 99%

Human papillomavirus infections and oral tumors

Syrjänen

2003

Medical Microbiology and Immunology

145

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In the past 20 years, there has been an increasing interest in human papillomaviruses (HPV) because of their potential role in the pathogenesis of malignant tumors. In 1983, we published the first evidence that HPV might be involved in oral squamous cell carcinomas. The identification of morphological similarities between oral and cervical mucosa lead us to this original proposal. In a recent meta-analysis, HPV was indeed confirmed as an independent risk factor for oral carcinoma. To date, totally more than 100 types of HPV have been identified. As in anogenital cancers, HPV type 16 is the most prevalent type in oral carcinomas. The benign oral lesions, associated with HPV infection, include squamous cell papilloma, condyloma acuminatum, verrucca vulgaris and focal epithelial hyperplasia (FEH). Papillomas and condylomas are mostly caused by HPV type 6 or 11, while oral verrucas are associated with the skin types 2 or 4. A family history of FEH has been suggested. The FEH lesions are caused by HPV types 13 and 32, only detected in oral epithelium. In immunocompromised patients, benign HPV-induced lesions are characterized by atypical morphology and the simultaneous detection of multiple HPV types. Oral benign HPV lesions are mostly asymptomatic, and may persist or regress spontaneously.

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“…Most of the tumors were glottic in location, but both of the supraglottic tumors contained HPV-18. A study of oral cavity verrucous carcinomas from 25 patients found that 40% of the cases contained HPV-18 DNA, and that only 12% of the cases contained HPV-6, HPV-11 or HPV-16 [104]. Therefore, there might be some difference in the susceptibility of different tissues to infection by or expression of HPV-18.…”

Section: Vefrltcolts Carcinomamentioning

confidence: 99%

A possible role for human papillomaviruses in head and neck cancer

Steinberg

DiLorenzo

1996

Cancer Metast Rev

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Human papillomaviruses (HPVs) cause benign tumors in the respiratory tract. Mounting evidence suggests that they also play a role in the etiology of a subset of head and neck cancers. Carcinomas in patients with a history of recurrent respiratory papillomatosis clearly are caused by persisting HPV interacting with one of more carcinogenic agents. Verrucous carcinomas of the oral cavity, tonsillar and tongue carcinomas are strongly linked with HPVs, based on molecular epidemiologic data. Tonsillar cancer have been shown to express HPV RNA, presumed necessary to induce and maintain a carcinoma, supporting a viral etiology. This paper reviews the molecular and cellular basis for considering HPVs as causative agents of cancer, and reviews the literature that considers the possible role of HPVs in head and neck cancer.

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Detection and Typing of Human Papillomavirus in Verrucous Carcinoma of the Oral Cavity Using the Polymerase Chain Reaction

Cited by 37 publications

References 50 publications

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Human papillomavirus infections and oral tumors

A possible role for human papillomaviruses in head and neck cancer

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