A possible role for human papillomaviruses in head and neck cancer

Steinberg, Bettie M.; DiLorenzo, Teresa P.

doi:10.1007/bf00049489

Cited by 80 publications

(51 citation statements)

References 156 publications

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“…Although there is some support for the hypothesis that HPV-induced tumors may have different biologic behavior than those caused by other carcinogenic agents 44 and that cells infected with HPV may be more susceptible to the action of other carcinogens, such as tobacco, alcohol, or other agents, 37 the epidemiologic evidence for an association between HPV status and clinical outcome is highly contradictory. Independently of the role that these viruses may play etiologically in UADT cancers-still an unresolved issueour results support the hypothesis that is unlikely that the presence of HPV DNA plays any role in patient prognosis.…”

Section: Discussionmentioning

confidence: 92%

“…The prevalence rate of HPV infection shows great variation among different studies, and the presence of the virus in tumors does not necessarily mean that it plays an etiologic or prognostic role. 37 The current investigation did not attempt to shed light on the role of HPV as a possible etiologic factor in UADT cancers, but rather as a prognostic variable.…”

Section: Discussionmentioning

confidence: 99%

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Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Pintos

Franco

Black

et al. 1999

Cancer

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Pintos

Franco

Black

et al. 1999

Cancer

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“…Other aetiological factors such as diet [46,47], oral hygiene and dentition [48,49], mouthwashes [50,51] and viral infections [52,53] have also been identi®ed but their role is inconsistent.…”

Section: Risk Factorsmentioning

confidence: 99%

Oral cancer in the UK: to screen or not to screen

1998

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Although oral squamous cell carcinoma accounts for only a small proportion of malignant neoplasms in the UK, oral cancer incidence and mortality rates have been rising in recent years. The natural history of oral cancer is not adequately understood at present and there is very little information about the epidemiology of precancerous lesions in the UK. There are also insucient data to provide ®rm evidence that the percentage of cases arising de novo is greater in the UK and the Western world as compared to the Indian subcontinent. Screening for oral cancer by visual examination is simple, inexpensive and causes little discomfort; however, there is no evidence for the eectiveness of screening for oral cancer either in reducing mortality from the disease or in reducing the incidence of invasive disease by detection and treatment of precancerous lesions. There is currently insucient evidence to recommend population screening for oral cancer in the UK. Measures aimed at primary prevention of the disease may be a more feasible method of disease control at present. #

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“…[4][5][6][7] Recently, molecular epidemiologic studies have shown a strong correlation between oncogenic HPV infections and a subset of oropharyngeal cancers. [8][9][10][11][12] It is not currently understood whether these HPV infections are an independent etiologic factor or a co-factor in the development of such tumours. Interestingly, a relative risk reduction from death of approximately 50% has been observed in HPV-associated tumours compared to those without detectable HPV DNA.…”

Section: Introductionmentioning

confidence: 99%

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas

Martínez

Wang

Hobson

et al. 2007

European Journal of Cancer

174

138

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Human papillomaviruses (HPVs) have been implicated in the pathogenesis of a subset of squamous cell carcinoma of the head and neck (SCCHN). The goal of this study was to compare the cellular gene expression profiles of HPV-positive and HPV-negative oropharyngeal carcinomas with those of the normal oral epithelium. Using Affymetrix Human U133A GeneChip, our results showed that 397 genes were differentially expressed in HPV-positive SCCHN compared to the normal oral epithelium. The up-regulated genes included those involved in cell cycle regulation (CDKN2A), cell differentiation (SFRP4) and DNA repair (RAD51AP1), while the down-regulated genes included those involved in proteolysis (PRSS3). We also found 162 differentially expressed genes in HPVnegative SCCHN compared to the normal oral mucosa. The up-regulated genes included those involved in cell proliferation (AKR1C3) and transcription regulation (SNAPC1), while downregulated genes included those involved in apoptosis (CLU) and RNA processing (RBM3). Our studies also identified a subgroup of 59 differentially expressed genes in HPV-positive SCCHN as compared to both HPV-negative SCCHN and normal oral tissues. Such up-regulated genes included those involved in nuclear structure and meiosis (SYCP2), DNA repair (RFC5), and transcription regulation (ZNF238). Genes involved in proteolysis (KLK8) and signal transduction (CRABP2) were found to be down-regulated in HPV-positive SCCHN. The results of GeneChip experiments were validated by quantitative real-time RT-PCR analysis of a few representative genes. Our results reveal specific gene expression patterns in HPV-positive and HPV-negative oropharyngeal squamous carcinomas that may serve as potential biomarkers for the development of SCCHN. Novelty and impact of the paper: Using a 22,200 human transcript oligonucleotide microarray platform, we have examined the gene expression profiles in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas as compared to the normal oropharyngeal mucosa. Our study has identified several new genes whose expression is specifically associated with the presence of HPV-16 in the oropharyngeal squamous mucosa. Furthermore, we have identified several genes whose expression is altered in HPVnegative SCCHN as compared to the normal oral mucosa. Results of our study could contribute to the understanding of pathogenic mechanisms involved in the development of HPV-positive and HPV-negative oropharyngeal cancers and consequently in the identification of potential biomarkers associated with these two subtypes of squamous cell carcinomas.

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A possible role for human papillomaviruses in head and neck cancer

Cited by 80 publications

References 156 publications

Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Oral cancer in the UK: to screen or not to screen

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas

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