Detection and typing of enteroviruses from CSF specimens from patients diagnosed with meningitis/encephalitis

Tavakoli, Norma P.; Wang, Heng; Nattanmai, Seela; Dupuis, Michelle; Fusco, Heather; Hull, Rene

doi:10.1016/j.jcv.2008.06.016

Cited by 40 publications

(52 citation statements)

References 28 publications

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“…Enteroviruses detected by molecular biology RT-PCR or Real Time PCR or cellular culture analysis show an incidence varying from 10 to 46% 9,12,15,17,19 . Herpesviruses, HHV6, VZV, and a mixed infection by HHV6/EV, were detected in a lower proportion [20][21][22] . In the present study in addition to enterovirus, positive samples for HSV (10%), EBV (3%) and HHV6 (3%) were observed.…”

Section: Discussionmentioning

confidence: 97%

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

Vidal

Almeida²,

Messias-Reason³

et al. 2011

Arq. Neuro-Psiquiatr.

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Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.

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Section: Discussionmentioning

confidence: 97%

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

Vidal

Almeida²,

Messias-Reason³

et al. 2011

Arq. Neuro-Psiquiatr.

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“…On physical exam she was alert and oriented with mild nuchal rigidity; otherwise, the rest of the examination was unremarkable. The serum white blood count was 11,000 cells/mm 3 , hemoglobin 13 g/dL, hematocrit 40% and platelets 301,000 cells/mm 3 This patient is the 29-year-old female roommate of the patient described above who presented with severe headaches around the same time the previously described patient had headaches. She also complained of a low grade fever and pain in the neck associated with photophobia and nausea but no vomiting.…”

Section: Casementioning

confidence: 60%

“…Enteroviruses are members of the family Picornaviridae and are responsible for a wide range of clinical manifestations, ranging from asymptomatic infection, mild febrile illness, conjunctivitis, and respiratory tract infections to more serious conditions such as meningoencephalitis and myocarditis [1][2][3]. The exact incidence of infection is difficult to appreciate due to the propensity of enteroviral infections to be asymptomatic [2], particularly in adults [4].…”

Section: Discussionmentioning

confidence: 99%

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Meningoencephalitis due to Enteroviral Infection – An Often Overlooked Etiology

McBath¹,

Sj²

2015

Journal of Immunology and Infectious Diseases

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Case Report Open AccessEnteroviruses have been implicated in recent outbreaks around the country, with symptoms ranging from gastrointestinal-like illness to respiratory infections. These viruses are well known causes of a much wider variety of clinical presentations and, due to the ease with which they spread from patient to patient, are a commonly reported cause of outbreaks. We report a case series of enteroviral infections of the central nervous system that involves three adults and two children, all of whom live in the same home.Enteroviruses are responsible for causing several recent well-publicized outbreaks in the United States, including gastrointestinal and upper respiratory infections. Enteroviruses are also capable of infecting the central nervous system, leading to manifestations of meningitis and encephalitis. Because enteroviruses are often overlooked as the etiology of CNS infections, we explore data from national surveillance, typical presentation and diagnostic information, as well as patterns of infection and transmission in an effort to remind practitioners to be mindful of this frequent cause of infection and its propensity to be spread from person to person. We present a case series that includes two confirmed cases of enteroviral meningoencephalitis, a presumed index case, and two cases involving children.

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“…The best diagnostic confirmatory approach is the PCR of CSF samples [54]. The most frequent encephalitis associated enterovirus found in United States is Coxsackie virus B5, followed by Echovirus 18 and 6 [55]. In Brazil there are no specific data on enterovirus encephalitis but in a study from 1998 to 2003 the most frequently isolated virus in enterovirus meningitis was Echovirus 30 [56].…”

Section: Enterovirus Encephalitismentioning

confidence: 99%