Detection and prevalence of serotypes of feline syncytial spumaviruses

Flower, Robert L.; Wilcox, G. E.; Cook, R. D.; Ellis, T.M.

doi:10.1007/bf01310964

Cited by 38 publications

(22 citation statements)

References 13 publications

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“…Among the FFVs two different serotypes have been characterized: the FUV7 like FVs and the F17/951-like serotypes [35,36,37,38]. Originally, the two distinct serotypes of FFV have been identified due to differential neutralization patterns, mainly based on sequence differences in Env Su (Env surface domain) [39].…”

Section: Classification Of a Complex Group Of Virusesmentioning

confidence: 99%

Non-Simian Foamy Viruses: Molecular Virology, Tropism and Prevalence and Zoonotic/Interspecies Transmission

Kehl

Tan

Materniak

2013

Viruses

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Within the field of retrovirus, our knowledge of foamy viruses (FV) is still limited. Their unique replication strategy and mechanism of viral persistency needs further research to gain understanding of the virus-host interactions, especially in the light of the recent findings suggesting their ancient origin and long co-evolution with their nonhuman hosts. Unquestionably, the most studied member is the primate/prototype foamy virus (PFV) which was originally isolated from a human (designated as human foamy virus, HFV), but later identified as chimpanzee origin; phylogenetic analysis clearly places it among other Old World primates. Additionally, the study of non-simian animal FVs can contribute to a deeper understanding of FV-host interactions and development of other animal models. The review aims at highlighting areas of special interest regarding the structure, biology, virus-host interactions and interspecies transmission potential of primate as well as non-primate foamy viruses for gaining new insights into FV biology.

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Section: Classification Of a Complex Group Of Virusesmentioning

confidence: 99%

Non-Simian Foamy Viruses: Molecular Virology, Tropism and Prevalence and Zoonotic/Interspecies Transmission

Kehl

Tan

Materniak

2013

Viruses

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“…FFV-derived vectors were propagated in Crandell feline kidney (CRFK) cells as described previously (10,35). CRFK-derived FFV-FAB cells suited for the rapid and sensitive titration of FFV infectivity were selected and maintained in CRFK cell medium supplemented with 500 g of G418 per ml (Roche, Mannheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

Application of Chimeric Feline Foamy Virus-Based Retroviral Vectors for the Induction of Antiviral Immunity in Cats

Schwantes

Truyen

Weikel

et al. 2003

J Virol

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In order to define the potential and applicability of replication-competent foamy virus-based vaccine vectors, recombinant feline foamy virus (FFV) vectors encoding defined segments of the feline calicivirus (FCV) capsid protein E domain were constructed. In cell cultures, these FFV-FCV vectors efficiently transduced and expressed a hybrid fusion protein consisting of the essential FFV Bet protein and the attached FCV E domains. The stability of the vectors in vitro was inversely correlated to the size of the heterologous insert. The deletion of a part of the FFV U3 sequence in these FFV-FCV vectors did not interfere with replication and titer in cell cultures but increased the genetic stability of the hybrid vectors. Selected chimeric vectors were injected into immunocompetent cats and persisted in the transduced host concomitant with a strong and specific humoral immune response against vector components. In a substantial number of cats, antibodies directed against the FCV E domain were induced by the FFV-FCV vectors, but no FCV-neutralizing activities were detectable in vitro. When the vaccinated cats were challenged with a high-titer FCV dose, sterile immunity was not induced by any of the hybrid FFV-FCV vectors. However, the FFV-FCV vector with a truncated U3 region of the long terminal repeat promoter significantly reduced the duration of FCV shedding after challenge and suppressed the appearance of FCV-specific ulcers. Possible mechanisms contributing to the partial protection will be discussed.The great success of applied virology during the last century has been mainly due to the development and application of efficient and safe antiviral vaccines. These prevent virus-mediated disease or spread of the infectious agent and have even resulted in the eradication of poxvirus (reviewed in reference 7). These achievements are on one hand based on the injection of defined virus-derived proteins, as in the case of the hepatitis B virus vaccine or inactivated viruses, which are both capable of inducing a stable and broadly reactive humoral immunity. Alternatively, attenuated, apathogenic virus variants and/or related viruses inducing a stable cross-protection are used. Modified live virus vaccines have the great advantage of mimicking the natural route and mode of virus replication, inducing not only a humoral, mainly immunoglobulin G (IgG)-mediated immunity, but also stimulating the cell-mediated and/or mucosal arm of the adaptive immune response (7). Although these strategies have been efficient in controlling various viruses pathogenic to humans and livestock animals, vaccines against some virus infections are presently either not available or display only a limited degree of protection (23).Over the last several years, novel vaccination strategies have been developed based on recombinant, chimeric viruses used to deliver and efficiently express heterologous vaccine antigens in the recipient (28). These novel strategies include not only prophylactic preexposure vaccination but also therapeutic postexposure im...

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“…Interestingly, more than one SFV serotype has been found to infect one species of primates and co-infection of a single animal with different SFVs has been reported ( [Hooks et al, 1972] and [Leendertz et al, 2008]). In cats, two distinct serotypes of FFV have been identified due to differential neutralization patterns ( [Hackett and Manning, 1971], [Mochizuki and Konishi, 1979] and [Flower et al, 1985]). FFV serotypes 951, F17 and others ( [Riggs et al, 1969] and [Helps and Harbour, 1997]) represent the F17/951-like serotype, whereas the FUV7-like viruses comprise the second serotype.…”

Section: Introductionmentioning

confidence: 99%

Pattern of seroreactivity against feline foamy virus proteins in domestic cats from Germany

Bleiholder

Mühle

Hechler

et al. 2011

Veterinary Immunology and Immunopathology

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Detection and prevalence of serotypes of feline syncytial spumaviruses

Cited by 38 publications

References 13 publications

Non-Simian Foamy Viruses: Molecular Virology, Tropism and Prevalence and Zoonotic/Interspecies Transmission

Non-Simian Foamy Viruses: Molecular Virology, Tropism and Prevalence and Zoonotic/Interspecies Transmission

Application of Chimeric Feline Foamy Virus-Based Retroviral Vectors for the Induction of Antiviral Immunity in Cats

Pattern of seroreactivity against feline foamy virus proteins in domestic cats from Germany

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