Detection and prevalence of early diabetic retinopathy in juvenile diabetics with diabetes for 10 years or more

Cahill, Mark; Wallace, David E.; Travers, S.; Lipinski, H; Aldington, S J; Costigan, Colm; Mooney, David J.

doi:10.1038/eye.2000.234

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Early complications of DR have been reported in adolescents with T1D between 2 to 5 years diabetes duration despite more intensive management [7]. reported to range between 2.3% and 57.6% [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. In Wales between 2003 and 2018 in 4,172 people diagnosed with T1D up to the age of 18 years eligible for screening (in those with T1D from 12 years) with gradable retinal photographs, the prevalence of background DR was 26.7%, referable DR 10.7% and proliferative DR 4.1% [26].…”

Section: Introductionmentioning

confidence: 99%

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Thomas¹,

Ng²

2020

Journal of Diabetes and Clinical Research

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Prevalence of DR is variable as reported in several studies. This variability is due to differences in study populations such as age, type of diabetes, and location i.e. community or hospital setting, methods of detecting diabetic retinopathy fundoscopy, digital photography and slit lamp examination and grading protocols used. The global prevalence of DR was 34.6% from a pooled analysis of 22,896 individuals with diabetes [8], this was updated in the International Diabetes Federation (IDF) atlas 9 th edition with any DR reported to be 27.0%, nonproliferative DR 25.2%, proliferative DR 1. 4% and DME 4.6% between 2015 and 2019 [9]. The lowest prevalence of any DR was reported in South East Asia at 12.5% and highest in the Western Pacific at 36.3%. The prevalence of DR in children and young people with diabetes has been

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Section: Introductionmentioning

confidence: 99%

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Thomas¹,

Ng²

2020

Journal of Diabetes and Clinical Research

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“…The Epidemiology of Diabetes Interventions and Complications and The Diabetes Control and Complications Trial showed that optimal T1D management significantly reduces the risk of development of DR, as demonstrated by the reduction of DR prevalence from 14-20% before the year 2000 to 3.7-6% after 2000 [61,117,118]. Despite the pediatric population being the one with the lowest risk of DR, the related literature refers to a prevalence ranging from 2.3% to 44% [119,120]. Whereas the risk of developing DR is minimal in children under 10 years old, puberty is considered the most important risk factor for developing and progressing retinopathy [121,122].…”

Section: Diabetic Retinopathymentioning

confidence: 99%

Pediatric Type 1 Diabetes: Mechanisms and Impact of Technologies on Comorbidities and Life Expectancy

Urbano

Farella

Brunetti

et al. 2023

IJMS

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Type 1 diabetes (T1D) is one of the most common chronic diseases in childhood, with a progressively increasing incidence. T1D management requires lifelong insulin treatment and ongoing health care support. The main goal of treatment is to maintain blood glucose levels as close to the physiological range as possible, particularly to avoid blood glucose fluctuations, which have been linked to morbidity and mortality in patients with T1D. Indeed, the guidelines of the International Society for Pediatric and Adolescent Diabetes (ISPAD) recommend a glycated hemoglobin (HbA1c) level < 53 mmol/mol (<7.0%) for young people with T1D to avoid comorbidities. Moreover, diabetic disease strongly influences the quality of life of young patients who must undergo continuous monitoring of glycemic values and the administration of subcutaneous insulin. In recent decades, the development of automated insulin delivery (AID) systems improved the metabolic control and the quality of life of T1D patients. Continuous subcutaneous insulin infusion (CSII) combined with continuous glucose monitoring (CGM) devices connected to smartphones represent a good therapeutic option, especially in young children. In this literature review, we revised the mechanisms of the currently available technologies for T1D in pediatric age and explored their effect on short- and long-term diabetes-related comorbidities, quality of life, and life expectation.

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“…The prevalence of DR has been found in CYP with diabetes to range between 10.5% and 57.6% depending on the age, duration of diabetes, methods of detecting DR and the care setting (ref. [18][19][20][21][22][23][24][25][26][27][28][29][30]. The youngest ages at which DR and STDR have been recorded is 5 and 15 years respectively, with the shortest duration of diabetes being 5 years and only five cases of STDR have been observed in children below the age of 18 years (ref.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for having diabetic retinopathy at first screening in persons with type 1 diabetes diagnosed under 18 years of age

Rafferty

Owens

Luzio

et al. 2020

Eye

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Objective: To determine the risk factors for having diabetic retinopathy (DR) in children and young people (CYP) with type 1 diabetes (T1DM) at first screening.Methods: Records from the Diabetes Eye Screening Wales (DESW) service for people in Wales, UK, with T1DM diagnosed under age 18 years were combined with other electronic health record (EHR) data in the Secure Anonymised Information Linkage (SAIL) Databank. Data close to the screening date were collected, and risk factors derived from multivariate, multinomial logistic regression modelling.Results: Data from 4,172 persons, with median (Lower Quartile, Upper Quartile) age 16.3 (13.0, 22.3) years and duration of diabetes 6.6 (2.3, 12.3) years were analysed. 62.6% (n = 2,613) had no DR, 26.7% (n = 1,112) background DR and 10.7% (n = 447) had referable DR (RDR). No RDR was observed under 19 years of age. Factors associated with an increased risk of DR were diabetes duration, elevated HbA1c and diastolic blood pressure. People diagnosed with T1DM before age 12 years had an odds ratio of 1.23 for developing DR for each year they had diabetes, compared with an odds ratio of 1.34 for those diagnosed at age 12 years or older.Conclusions: This study found that 37.4% of the study cohort had DR at first screening, the risk being greater the longer the duration of diabetes or higher the HbA1c and diastolic blood pressure. In addition, people diagnosed at 12 years of age or over were more likely to have DR with each additional year with diabetes.

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Detection and prevalence of early diabetic retinopathy in juvenile diabetics with diabetes for 10 years or more

Cited by 6 publications

References 24 publications

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Pediatric Type 1 Diabetes: Mechanisms and Impact of Technologies on Comorbidities and Life Expectancy

Risk factors for having diabetic retinopathy at first screening in persons with type 1 diabetes diagnosed under 18 years of age

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