Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

Okitsu, Shoko; Khamrin, Pattara; Thongprachum, Aksara; Nishimura, Shigeyuki; Kalesaran, Angela F. C.; Takanashi, Sayaka; Shimizu, Hiroyuki; Hayakawa, Satoshi; Mizuguchi, Masashi; Ushijima, Hiroshi

doi:10.1016/j.meegid.2014.09.019

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…Only on the basis of statistical analysis on clinical manifestation of cosavirus and its co-infection, we can conclude its significant association with gastroenteritis. Our data only supports the previous studies reported association of cosavirus in gastroenteritis from other countries 16,[28][29][30][31][32][33] . Previously cosavirus was only reported in stool samples of patient suspected for the acute flaccid paralysis (AFP) in India 34 .…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwsupporting

confidence: 78%

“…In 2012 Stocker et al reported presence for the cosavirus in Patients with gastroenteritis as well as in control group 30 . Very low prevalence (0.01% to 3.6%) of cosavirus was reported from other countries like in Japan, Thailand and Brazil 28,30,33 . In this study we found 3% prevalence of cosavirus.…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 85%

“…Cosavirus is reported globally in acute gastroenteritis cases, AFP cases, lung transplant recipient and in sewage water [28][29][30][31][32] , still its significant presence is not defined in gastroenteritis cases. In 2012 Stocker et al reported presence for the cosavirus in Patients with gastroenteritis as well as in control group 30 .…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

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2016

IJPSR

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Viral gastroenteritis is one of the major causes of childhood mortality in India. About 30 to 50 % gastroenteritis caused by unknown etiological agents. This study was aimed to identify unknown RNA viral etiology and their clinical manifestation with pediatric acute gastroenteritis, conducted at tertiary care hospital of Uttar Pradesh, North India from July 2012 to December 2013. A total of 234 patients with their clinical profiling were enrolled in this study. Identification of viruses was performed by serological (ELISA for rotavirus) and molecular methods (PCR for astrovirus, norovirus and cosavirus). Quantitative and qualitative data analysis performed by Chi-square and student t-test. Total subjects positive for infection was 35%.Co-infection present in 21% cases. Rotavirus, astrovirus, norovirus and cosavirus were detected in 25%, 10%, 7% and 3% subjects respectively. Other than diarrhea, vomiting was a significant symptom (p=0.0002). Severity of diarrhea was more than vomiting with 5.5±2.7 vs. 3.3±2.6 episodes in 24 hrs. Mean duration of symptoms 3.7±9.1. Eighty percent virus positivity were below the age of 6 years (39.2 ±34.6, median=34 months) and 65% males were positive. This study defines the viral etiology and their clinical association with gastroenteritis. This is the first report of prevalence and co-infection of cosavirus in this region. The outcome of the study provides a baseline data which can be used to design and develop the preventive strategies against unknown etiologies like cosavirus.

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Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwsupporting

confidence: 78%

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 85%

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

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2016

IJPSR

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“…Human Cosavirus infection reports are still very limited worldwide, but the association of the viruses with gastroenteritis is increasing 4 , 8 , 9 . In Brazil, there is only one study considering Cosaviruses role; nevertheless its association with gastroenteritis could not be established 3 .…”

Section: Resultsmentioning

confidence: 99%

Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil

Costa

Luchs

Milagres

et al. 2018

Sci Rep

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In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute flaccid paralysis patient. This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus.

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“…ictvonline.org/virusTaxonomy.asp). However, five additional species (B to F) of at least 30 genotypes have been reported [1,2,8,9].…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel cosavirus species in faeces of children and its relationship with acute gastroenteritis in China

et al. 2017

Clinical Microbiology and Infection

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Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

Cited by 19 publications

References 25 publications

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Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil

Identification of a novel cosavirus species in faeces of children and its relationship with acute gastroenteritis in China

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