Identification of a novel cosavirus species in faeces of children and its relationship with acute gastroenteritis in China

Yu, Jie-mei; Ao, Yuanyun; Li, L.-L.; Duan, Zhaojun

doi:10.1016/j.cmi.2017.02.018

Cited by 12 publications

(12 citation statements)

References 24 publications

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“…Summarizing, the analysis showed that the values of virus prevalence in drinking water, sewage polluted water and human blood were dependent on each other [13].…”

Section: Resultsmentioning

confidence: 97%

Assessment of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan

Ahmad¹,

Adnan²,

Nadeem³

et al. 2018

Ann Agric Environ Med.

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of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan. Ann Agric Environ Med. 2018; 25(4): 708-713. AbstractIntroduction. Molecular studies have confirmed the silent circulation of enterovirus (EntV) and hepatitis A virus in the environment, even in the absence of clinical manifestation. Viral pathogens are among the major causes of disease outbreaks, particularly in the bigger cities and both in the developed and underdeveloped nations. Materials and method. Between June 2016 -June 2017, 97 samples of drinking water, river water polluted with sewage and blood were selected and obtained from high risk communities in Pakistan. Negatively charged membrane filters were used to concentrate the virus, followed by the use of specific PCR primers set for quick identification of the waterborne viruses. Results. Enteroviruses were recovered from 40%, 28.57% and 33.33% of river water polluted with sewage samples in Lahore, Islamabad and Rawalpindi, respectively, while the presence of 13.13% and 11.76% of viral load was also confirmed in the drinking water of Lahore and Rawalpindi, respectively. A high prevalence of HAV (12.5% and 21.05%) was also verified in the clinical samples. Phylogenetic analysis indicated close resemblance of HAV isolates with the Indian strains. This study is the first ever comparative analysis of the EntV and HAV isolated from environmental samples and clinical specimen on a molecular level. Conclusions. The parallel surveillance of EntV and HAV in the river water polluted with sewage, and clinical samples is quite helpful for controlling and reducing the disease burden of the waterborne illnesses.

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“…Summarizing, the analysis showed that the values of virus prevalence in drinking water, sewage polluted water and human blood were dependent on each other [13].…”

Section: Resultsmentioning

confidence: 97%

Assessment of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan

Ahmad¹,

Adnan²,

Nadeem³

et al. 2018

Ann Agric Environ Med.

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“…EVs have the highest proportion of co-infection with HCoSV followed by AdVs, RoVs, and NoVs. The high rate of co-infection with classic enteric viruses may indicate the role of these viruses in causing symptoms in patients infected with these newly discovered viruses ( 6 , 46 ). The other possible point that is against the pathologic role of these viruses in the development of GE is the low viral load in patients with GE, which might be due to transient infection and the lack of replication in the gastrointestinal tract ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

2022

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Background: Bufavirus (BuV), Human Cosavirus (HCoSV), and Saffold (SAFV) virus are three newly discovered viruses and have been suggested as possible causes of gastroenteritis (GE) in some studies. The aim of the present study was to estimate the overall prevalence of viruses and their association with GE.Methods: A comprehensive systematic search was conducted in Scopus, Web of Science, PubMed, and Google scholar between 2007 and 2021 to find studies on the prevalence of BuV, HCoSV, and SAFV viruses.Result: Meta-analysis of the 46 included studies showed the low prevalence of BuV (1.%, 95% CI 0.6–1.5%), HCoSV (0.8%, 95% CI 0.4–1.5%), and SAFV (1.9%, 95% CI 1.1–3.1%) worldwide. Also, no significant association between these viruses and GE was observed. BuV was isolated from patients with GE in Africa, while SAFV was more common in Europe. BuV1 and BuV2 have the same prevalence between the three identified genotypes of BuV. HCoSV-C was the most prevalent genotype of HCoSV, and SAFV2 was the commonest genotype of SAFV. All of these viruses were more prevalent in children older than 5 years of age.Conclusion: This was the first meta-analysis on the prevalence and association of BuV, HCoSV, and SAFV with GE. While no significant association was found between infection with these viruses and GE, we suggest more studies, especially with case-control design and from different geographical regions in order to enhance our knowledge of these viruses.

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“…Human Cosavirus infection reports are still very limited worldwide, but the association of the viruses with gastroenteritis is increasing 4 , 8 , 9 . In Brazil, there is only one study considering Cosaviruses role; nevertheless its association with gastroenteritis could not be established 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Enteroviruses, polioviruses, hepatoviruses and aphthoviruses are the most exhaustively characterized animal pathogens, and are associated with a wide spectrum of clinical manifestations, including undifferentiated febrile illness, respiratory illness, aseptic meningitis and acute flaccid paralysis (AFP) 1 . Recently, metagenomics analysis made possible the identification of three new human picornaviruses: klassevirus, salivirus, and cosavirus 2 – 4 . The pathogenicity of Cosaviruses in humans remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil

Costa

Luchs

Milagres

et al. 2018

Sci Rep

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In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute flaccid paralysis patient. This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus.

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Identification of a novel cosavirus species in faeces of children and its relationship with acute gastroenteritis in China

Abstract: A low prevalence of HCosV was detected, but a novel Cosavirus species was found in children with and without gastroenteritis in this study. The evidence did not support a causative role for the novel virus in paediatric AGE.

Cited by 12 publications

References 24 publications

Assessment of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan

Assessment of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil

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