Detection and Diagnostic Accuracy of Rapid Urine Lipoarabinomannan Lateral-Flow Assay in Pulmonary Tuberculosis patients in Nigeria

Joseph, Aneio-Okopi A.; Okojokwu, Ocheme Julius; Joshua, Adetunji; Annaejane, Onoja; Folashade, Aminu; Gabriel, Ikwulono; Augustine, Ebonyi O.; Emeka, E. N.; Onyemocho, Audu

doi:10.31586/epidemiology.0301.05

Cited by 2 publications

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“…Presumptive TB cases were included in the study and urine sample was obtained from each child for LAM Alere Determine test (Alere Determine TB-LAM, Waltham, MA, USA) [21] and GeneXpert method. Caretakers or parents were oriented on how to collect child's midstream urine samples by trained data collectors.…”

Section: Laboratory Data Collection and Processingmentioning

confidence: 99%

GeneXpert has perfect test agreement with WHO recommended TB lipoarabinomannan antigen test for the diagnosis of TB among under five children from urine sample in Tuberculosis endemic setting of Ethiopia

Derese,

Teklu,

Kumalo

et al. 2023

Preprint

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Background Tuberculosis (TB) is one of the leading public health problems in children mainly due to difficulties in the diagnosis of disease in children. This study aimed to detect the diagnostic agreement between GeneXpert MTB/RIF and WHO recommended lipoarabinomannan (LAM) antigen test for the detection of TB in children using urine samples Methods Institutional based cross-sectional study was conducted on 337 children in Wolaita Sodo University comprehensive hospital. LAM antigen and GeneXpert methods were used to detect TB from urine sample. The agreement between two tests was assessed using Kappa statistics with the standard error (SE), concordance and disagreements statistics. Logistic regression was used to determine factors associated with TB and P-values less than 0.05 were considered as having a statistically significant association. Results M. tuberculosis was detected in 26 using TB LAM giving an overall prevalence of 7.7% and 29 (8.6%) using GeneXpert. The two tests had almost perfect agreement (Concordance of 99.1% and kappa value of 0.94 with standard error of 0.034) for the detection of TB in urine sample. Co-infections with other diseases [AOR = 4.00: 95% CI, 1.428, 11.203], cough for the previous two weeks [AOR = 3.700: 95% CI, 1.039, 13.183], night sweat [AOR = 4.255: 95% CI, 1.453, 12.463] and loss of appetite [AOR = 3.994: 95% CI, 1.444, 11.045] had significant associations with pulmonary TB among children in the study area. Conclusion Tuberculosis was still the public health concern among children of under five years old in the study area. The GeneXpert had almost perfect test agreement with WHO recommended TB LAM antigen test for the diagnosis TB among under five children, however, it needs further confirmation study with large sample size to use as diagnostic test.

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Section: Laboratory Data Collection and Processingmentioning

confidence: 99%

GeneXpert has perfect test agreement with WHO recommended TB lipoarabinomannan antigen test for the diagnosis of TB among under five children from urine sample in Tuberculosis endemic setting of Ethiopia

Derese,

Teklu,

Kumalo

et al. 2023

Preprint

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Concomitant opening of a bulk-gap with an emerging possible Majorana zero mode

et al. 2019

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Majorana quasiparticles are generally detected in a 1D topological superconductor by tunneling electrons into its edge, with an emergent zero-bias conductance peak (ZBCP). However, such a ZBCP can also result from other mechanisms, hence, additional verifications are required. Since the emergence of a Majorana must be accompanied by an opening of a topological gap in the bulk, two simultaneous measurements are performed: one in the bulk and another at the edge of a 1D InAs nanowire coated with epitaxial aluminum. Only under certain experimental parameters, a closing of the superconducting bulk-gap that is followed by its reopening, appears simultaneously with a ZBCP at the edge. Such events suggest the occurrence of a topologically non-trivial phase. Yet, we also find that ZBCPs are observed under different tuning parameters without simultaneous reopening of a bulk-gap. This demonstrates the importance of simultaneous probing of bulk and edge in the identification of Majorana edge-states.

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Detection and Diagnostic Accuracy of Rapid Urine Lipoarabinomannan Lateral-Flow Assay in Pulmonary Tuberculosis patients in Nigeria

Cited by 2 publications

References 0 publications

GeneXpert has perfect test agreement with WHO recommended TB lipoarabinomannan antigen test for the diagnosis of TB among under five children from urine sample in Tuberculosis endemic setting of Ethiopia

GeneXpert has perfect test agreement with WHO recommended TB lipoarabinomannan antigen test for the diagnosis of TB among under five children from urine sample in Tuberculosis endemic setting of Ethiopia

Concomitant opening of a bulk-gap with an emerging possible Majorana zero mode

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