Detection and characterization of hepatitis B virus strains from wild-caught gorillas and chimpanzees in Cameroon, Central Africa

Njouom, Richard; Sadeuh, Serge Alain; Nerrienet, Eric; Foupouapouognigni, Yacouba; Rousset, Dominique

doi:10.1016/j.meegid.2010.05.002

Cited by 16 publications

(14 citation statements)

References 19 publications

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“…Phylogenetic analysis of the HBV strains using 415 bp S gene fragments confirmed the grouping of the novel chimpanzee HBV strains with previously published HBV chimpanzee sequences and the grouping of the two novel gorilla HBV sequences with previously published HBV strains AJ131657 and FJ98095-97 [19] , [21] . (The novel HBV sequence ECO50065LIP3J and FJ98095 were retrospectively identified as originating from the same gorilla in Limbe Wildlife Centre) (Data not shown).…”

Section: Resultssupporting

confidence: 80%

“…1a), demonstrated monophyletic groupings for each human genotype (A–H), a clade containing gibbon and orangutans variants and a third containing chimpanzee and gorilla HBV sequences, each supported by high bootstrap values. Sequences of all novel chimpanzee HBV variants, irrespective of their sub species specific host, clustered with HBV sequences previously obtained from P. t. ellioti [21]. As the study samples were obtained from captive settings where P. t. troglodytes and P. t. ellioti are frequently co-housed, it remains unclear whether these findings reflect the HBV genotype distribution among wild chimpanzees in Cameroon or whether infection of troglodytes by ellioti -derived strains occurred in captivity.…”

Section: Resultsmentioning

confidence: 66%

“…Their occurrence demonstrates that despite their genetic divergence, human and non-human associated variants of HBV can share hosts in nature. A recently published study characterising HBV variants infecting ape populations in Cameroon [21] demonstrated the existence of a gorilla-specific HBV strain and evidence of recombination between HBV strains circulating in chimpanzees. This and previous studies of HBV nucleotide sequence similarity [14] indicate non-human primates (NHP) have distinct species-specific variants of HBV distinguishable both from each other and from human HBV despite occupying overlapping geographical areas.…”

Section: Introductionmentioning

confidence: 99%

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Species Association of Hepatitis B Virus (HBV) in Non-Human Apes; Evidence for Recombination between Gorilla and Chimpanzee Variants

et al. 2012

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Hepatitis B virus (HBV) infections are widely distributed in humans, infecting approximately one third of the world's population. HBV variants have also been detected and genetically characterised from Old World apes; Gorilla gorilla (gorilla), Pan troglodytes (chimpanzee), Pongo pygmaeus (orang-utan), Nomascus nastusus and Hylobates pileatus (gibbons) and from the New World monkey, Lagothrix lagotricha (woolly monkey). To investigate species-specificity and potential for cross species transmission of HBV between sympatric species of apes (such as gorillas and chimpanzees in Central Africa) or between humans and chimpanzees or gorillas, variants of HBV infecting captive wild-born non-human primates were genetically characterised. 9 of 62 chimpanzees (11.3%) and two from 11 gorillas (18%) were HBV-infected (15% combined frequency), while other Old world monkey species were negative. Complete genome sequences were obtained from six of the infected chimpanzee and both gorillas; those from P. t .ellioti grouped with previously characterised variants from this subspecies. However, variants recovered from P. t. troglodytes HBV variants also grouped within this clade, indicative of transmission between sub-species, forming a paraphyletic clade. The two gorilla viruses were phylogenetically distinct from chimpanzee and human variants although one showed evidence for a recombination event with a P.t.e. -derived HBV variant in the partial X and core gene region. Both of these observations provide evidence for circulation of HBV between different species and sub-species of non-human primates, a conclusion that differs from the hypothesis if of strict host specificity of HBV genotypes.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Species Association of Hepatitis B Virus (HBV) in Non-Human Apes; Evidence for Recombination between Gorilla and Chimpanzee Variants

et al. 2012

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“…NHP plasmas used in this study were from previous studies designed to document viral infections in various species of NHP in Cameroon. 13,14 Briefly, these samples were collected from 1997 to 2006 from wild-born orphaned monkeys living mainly in the southern rain forest areas of Cameroon. These animals have been transferred to zoos or rescue centres, generally after their mothers had been killed by hunters.…”

Section: Samplementioning

confidence: 99%

Detection of hepatitis E virus antibodies among Cercopithecidae and Hominidae monkeys in Cameroon

Modiyinji

Atsama

Chavely

et al. 2019

J of Medical Primatology

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We screened hepatitis E from 15 species of non-human primates. Anti-HEV IgG was detected in 11.1% (1/9) Mandrillus sphinx, 14.3% (2/14) Gorilla gorilla, 5.9% (4/67) pan troglodytes and 8.7% (2/23) Mandrillus leucophaeus, whereas anti-HEV IgM was detected in 1.5% (1/18) papio Anubis, 28.6% (2/7) Cercocebus agilis and 1.5% (1/67) pan troglodyte. K E Y W O R D SCameroon, hepatitis E virus, non-human primates

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“…It is therefore necessary in endemic areas to document the frequency of HBV infections in human and NHP populations. In a previous study, we show a high prevalence of HBV infection in chimpanzees (6.9%) and gorillas (11.6%) populations in Cameroon [9]. No information is available on the prevalence of HBV infection in Cercopithecidae monkey populations in Cameroon.…”

Section: Hbsag and Hepatitis B Virus (Hbv) Dna In Wild‐caught Cercopmentioning

confidence: 99%

Prevalence of hepatitis B virus infection among Cercopithecidae monkeys in Cameroon

Foupouapouognigni

Serge

Njouom

2011

Journal of Medical Primatology

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Detection and characterization of hepatitis B virus strains from wild-caught gorillas and chimpanzees in Cameroon, Central Africa

Cited by 16 publications

References 19 publications

Species Association of Hepatitis B Virus (HBV) in Non-Human Apes; Evidence for Recombination between Gorilla and Chimpanzee Variants

Species Association of Hepatitis B Virus (HBV) in Non-Human Apes; Evidence for Recombination between Gorilla and Chimpanzee Variants

Detection of hepatitis E virus antibodies among Cercopithecidae and Hominidae monkeys in Cameroon

Prevalence of hepatitis B virus infection among Cercopithecidae monkeys in Cameroon

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