Detection of hepatitis E virus antibodies among Cercopithecidae and Hominidae monkeys in Cameroon

Abstract

We screened hepatitis E from 15 species of non-human primates. Anti-HEV IgG was detected in 11.1% (1/9) Mandrillus sphinx, 14.3% (2/14) Gorilla gorilla, 5.9% (4/67) pan troglodytes and 8.7% (2/23) Mandrillus leucophaeus, whereas anti-HEV IgM was detected in 1.5% (1/18) papio Anubis, 28.6% (2/7) Cercocebus agilis and 1.5% (1/67) pan troglodyte. K E Y W O R D SCameroon, hepatitis E virus, non-human primates

Serological and molecular investigation of hepatitis E virus in pigs reservoirs from Cameroon reveals elevated seroprevalence and presence of genotype 3

“…There is accumulated evidence that HEV is enzootic in a broad range of animals in Cameroon. Serological analyses have revealed the presence of anti-HEV antibodies among pigs and nonhuman primates in previous studies in Cameroon [12,13]. We noted high anti-HEV seropositivity in this study of 47.7% similarly to the 43.2% that was previously reported in the North and West regions of Cameroon [12], confirming that pigs are indeed a main reservoir for HEV.…”

Seroprevalence of Hepatitis E Virus Infection and Factors Associated in HIV Infected Patients in Yaoundé (Cameroon)

“…All our patients were taking the antiretroviral treatment as recommended by national guidelines. Sixty-nine patients (76.7%) had a CD4 count greater than 200 cells per mm 3 . The HIV viral load was undetectable for 68 patients (75.6%).…”

“…The virus infects humans and animals such as pork and primates [2] [3]. A zoonotic transmission exists in humans through the consumption of porcine or monkeys foods, thought the consumption of the latter is prohibited [3] [4]. Contaminated water is also a route of transmission [2] [3] [5].…”

An epidemiological synthesis of emerging and re-emerging zoonotic disease threats in Cameroon, 2000–2022: a systematic review

“…Second, based on the risk of bias analysis, 73 out of the 76 studies included utilized a sampling frame that was not representative of the target population and none were representative of the national demographics. Third, some zoonotic diseases of known aetiology such as hepatitis E virus infection, fascioliasis, and microsporidiosis were excluded; human African trypanosomiasis was excluded because of indistinctness with the subspecies (zoonotic Trypanosoma brucei rhodesiense versus non-zoonotic Trypanosoma brucei gambiense ) in some studies [27] , [28] , [29] . Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) was intentionally not indexed, as while animal–human–animal cycles have occurred, the pandemic is dominated by human-to-human transmission, confounding observation of this dynamic [30] .…”