Detecting violations of sensory expectancies following cerebellar degeneration: A mismatch negativity study

Moberget, Torgeir; Karns, Christina M.; Deouell, Leon Y.; Lindgren, Magnus; Knight, Robert T.; Ivry, Richard B.

doi:10.1016/j.neuropsychologia.2008.03.016

Cited by 60 publications

(53 citation statements)

References 86 publications

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“…EEG research has identified a potent marker of violations of sensory expectations, the mismatch negativity response (MMN). This response is delayed in patients with cerebellar degeneration when the sensory violation is in the temporal domain (Moberget et al 2008). The results appear to be somewhat specific to timing given that the patients' MMN to pitch and location deviants was unaffected.…”

Section: Cerebellar Contributions To Perceptual Timing: Neuropsycholomentioning

confidence: 74%

Cerebellum and Timing

Spencer

Ivry

2013

Handbook of the Cerebellum and Cerebellar Disorders

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A functional characterization of the cerebellum centers on the hypothesis that this structure is essential for the representation of temporal relationships in the subsecond range. This hypothesis is supported by evidence involving a wide range of methods, including lesion studies, neuroimaging, and, to a limited extent, stimulation studies with transcranial magnetic stimulation. The extent of the cerebellar timing domain is not limited to tasks involving sensorimotor control but also extends to perceptual tasks that require the precise timing of salient events. Moreover, the timing hypothesis provides a parsimonious account of the cerebellar contribution to sensorimotor learning. This review presents a summary of this literature as well as highlights some of the limitations of cerebellar timing. History/BackgroundDavid Marr, in his 1969 classic A Theory of the Cerebellar Cortex, proposed that the "happy combination" of simple and repeating fine structure in the cerebellum was ideal for motor learning (Marr 1969). While Marr's model continues to inspire many lines of research, the regularity of cerebellar anatomy had already captivated the attention of anatomists, calling for a concise computational account of how the

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Section: Cerebellar Contributions To Perceptual Timing: Neuropsycholomentioning

confidence: 74%

Cerebellum and Timing

Spencer

Ivry

2013

Handbook of the Cerebellum and Cerebellar Disorders

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“…Activation in the dorsal premotor cortex was modulated by the metric structure of the auditory stimulus (27), subjects' cognitive set (e.g., motor imagery) (28), and their musical expertise (28,29). Furthermore, cerebellum and premotor cortex were involved in motor and perceptual timing, particularly at the millisecond range (12,(30)(31)(32)(33)(34)(35). Patients with cerebellar lesions showed increased variability on temporal production tasks such as rhythmic tapping (36).…”

Section: Resultsmentioning

confidence: 99%

Long-term music training tunes how the brain temporally binds signals from multiple senses

Lee

Noppeney

2011

Proc. Natl. Acad. Sci. U.S.A.

154

183

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Practicing a musical instrument is a rich multisensory experience involving the integration of visual, auditory, and tactile inputs with motor responses. This combined psychophysics-fMRI study used the musician's brain to investigate how sensory-motor experience molds temporal binding of auditory and visual signals. Behaviorally, musicians exhibited a narrower temporal integration window than nonmusicians for music but not for speech. At the neural level, musicians showed increased audiovisual asynchrony responses and effective connectivity selectively for music in a superior temporal sulcus-premotor-cerebellar circuitry. Critically, the premotor asynchrony effects predicted musicians' perceptual sensitivity to audiovisual asynchrony. Our results suggest that piano practicing fine tunes an internal forward model mapping from action plans of piano playing onto visible finger movements and sounds. This internal forward model furnishes more precise estimates of the relative audiovisual timings and hence, stronger prediction error signals specifically for asynchronous music in a premotor-cerebellar circuitry. Our findings show intimate links between action production and audiovisual temporal binding in perception.audiovisual synchrony | multisensory integration | sensorimotor learning | crossmodal integration | experience-dependent plasticity P racticing a musical instrument is a rich multisensory experience involving the integration of visual, auditory, and tactile inputs with motor responses. The musician's brain, thus, provides an ideal model to study experience-dependent plasticity in humans (1, 2).Previous research in musicians has focused on neural plasticity affecting unisensory and motor processing. Little is known about how musical expertise alters the integration of inputs from multiple senses. Because musical performance requires precise timing, musical expertise may specifically modulate the temporal binding of sensory signals. Given the variability in physical and neural transmission times, sensory signals do not have to be precisely synchronous but must co-occur within a temporal window that flexibly adapts to the temporal statistics of the sensory inputs as a consequence of music (3) or audiovisual training (4). At the neural level, audiovisual (a)synchrony processing relies on a widespread neural system encompassing subcortical, primary sensory, higher-order association, cerebellar, and premotor areas (5-8).This study used the musician's brain as a model to investigate how long-term sensory-motor experience (i.e., piano practicing) shapes the neural processes underlying temporal binding of auditory and visual signals. We presented subjects with synchronous and asynchronous speech and piano music as two stimulus classes that are both characterized by a rich hierarchical temporal structure but linked to different motor effectors (mouth vs. hand). Comparing the effect of musical expertise on synchrony perception of speech and music allowed us to dissociate generic and context-specific neural mechanisms ...

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“…Unlike previous studies which used a limited number of SOAs (two or three) and report an effect of temporal regularity on MMN amplitude (Imada et al, 1993;Takegata and Morotomi, 1999;Moberget et al, 2008), the current study used online randomization, i.e. no predefined set of SOAs, to generate irregular temporal structure.…”

Section: Discussionmentioning

confidence: 99%

Temporal regularity effects on pre-attentive and attentive processing of deviance

Schwartze

Rothermich

Schmidt-Kassow

et al. 2011

Biological Psychology

114

117

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Temporal regularity allows predicting the temporal locus of future information thereby potentially facilitating cognitive processing. We applied event-related brain potentials (ERPs) to investigate how temporal regularity impacts pre-attentive and attentive processing of deviance in the auditory modality. Participants listened to sequences of sinusoidal tones differing exclusively in pitch. The inter-stimulus interval (ISI) in these sequences was manipulated to convey either isochronous or random temporal structure. In the pre-attentive session, deviance processing was unaffected by the regularity manipulation as evidenced in three event-related-potentials (ERPs): mismatch negativity (MMN), P3a, and reorienting negativity (RON). In the attentive session, the P3b was smaller for deviant tones embedded in irregular temporal structure, while the N2b component remained unaffected. These findings confirm that temporal regularity can reinforce cognitive mechanisms associated with the attentive processing of deviance. Furthermore, they provide evidence for the dynamic allocation of attention in time and dissociable pre-attentive and attention-dependent temporal processing mechanisms.Article II

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Detecting violations of sensory expectancies following cerebellar degeneration: A mismatch negativity study

Cited by 60 publications

References 86 publications

Cerebellum and Timing

Cerebellum and Timing

Long-term music training tunes how the brain temporally binds signals from multiple senses

Temporal regularity effects on pre-attentive and attentive processing of deviance

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