Detecting the translocation of DNA through a nanopore using graphene nanoribbons

Traversi, Floriano; Raillon, Camille; Benameur, S. M.; Liu, K.; Khlybov, S. V.; Tosun, Mahmut; Krasnozhon, Daria; Kis, András; Radenović, Aleksandra

doi:10.1038/nnano.2013.240

Cited by 351 publications

(346 citation statements)

References 44 publications

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“…Our results imply that MoS 2 nanopore membranes can compete with graphene nanopore membranes in terms of spatial resolution and possibly better performance for transverse detection. 13 …”

Section: Resultsmentioning

confidence: 99%

Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation

et al. 2014

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Atomically thin nanopore membranes are considered to be a promising approach to achieve single base resolution with the ultimate aim of rapid and cheap DNA sequencing. Molybdenum disulfide (MoS2) is newly emerging as a material complementary to graphene due to its semiconductive nature and other interesting physical properties that can enable a wide range of potential sensing and nanoelectronics applications. Here, we demonstrate that monolayer or few-layer thick exfoliated MoS2 with subnanometer thickness can be transferred and suspended on a predesigned location on the 20 nm thick SiN x membranes. Nanopores in MoS2 are further sculpted with variable sizes using a transmission electron microscope (TEM) to drill through suspended portions of the MoS2 membrane. Various types of double-stranded (ds) DNA with different lengths and conformations are translocated through such a novel architecture, showing improved sensitivity (signal-to-noise ratio >10) compared to the conventional silicon nitride (SiN x ) nanopores with tens of nanometers thickness. Unlike graphene nanopores, no special surface treatment is needed to avoid hydrophobic interaction between DNA and the surface. Our results imply that MoS2 membranes with nanopore can complement graphene nanopore membranes and offer potentially better performance in transverse detection.

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“…Our results imply that MoS 2 nanopore membranes can compete with graphene nanopore membranes in terms of spatial resolution and possibly better performance for transverse detection. 13 …”

Section: Resultsmentioning

confidence: 99%

Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation

et al. 2014

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“…First experimental results on DNA translocation through graphene ribbons with nanopores were reported in 2013 [80] (Fig. 4C).…”

Section: Inplane Transport Of a Graphene Nanoribbon With A Nanoporementioning

confidence: 96%

“…Theoretical studies show that an armchair ribbon will be semiconducting [66][67][68][69] and that a zigzag-edged ribbon is metallic with a current profile that peaks at the edges [66,[69][70][71]. Both armchair and zigzag nanoribbons have been proposed to present promising platforms for DNA sequencing in a large number of theoretical reports [72][73][74][75][76][77][78][79], and experimentalists have begun to explore this approach [80][81][82][83][84][85].…”

Section: Inplane Transport Of a Graphene Nanoribbon With A Nanoporementioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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“…Another possibility for graphene-based DNA sensors, [202] is to configure a graphene nanoribbon FET with a nanopore and to probe the subtle differences in the conductance as the negatively charged DNA molecules translocating through the nanopore. [203] Interestingly, single-stranded DNA can also be used as a sensitizing agent to selectively probe various gases. [29] Contrarily to the inert sensing behavior of clean GFETs to various gas vapor such as dimethylmethylphosphonate (DMMP, black line, Fig.…”

Section: Gfet Glucose Dna and Protein Biosensorsmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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Abstract. 10Recent research trends now offer new opportunities for developing the next generations of label-free biochemical sensors using graphene and other two-dimensional materials. While the physics of graphene transistors operated in electrolyte is well grounded, important chemical challenges still remain to be addressed, namely the impact of the chemical functionalizations of graphene on the key electrical parameters and the sensing performances. In fact, graphene -at least ideal graphene -is highly chemically inert. The 15 functionalizations and chemical alterations of the graphene surface -both covalently and non-covalently -are crucial steps that define the sensitivity of graphene. The presence, reactivity, adsorption of gas and ions, proteins, DNA, cells and tissues on graphene have been successfully monitored with graphene. This review aims to unify most of the work done so far on biochemical sensing at the surface of a (chemically functionalized) graphene field-effect transistor and the challenges that lie ahead. We are convinced that graphene biochemical sensors 20 hold great promises to meet the ever-increasing demand for sensitivity, especially looking at the recent progresses suggesting that the obstacle of Debye screening can be overcome.2

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Detecting the translocation of DNA through a nanopore using graphene nanoribbons

Cited by 351 publications

References 44 publications

Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation

Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation

Graphene nanodevices for DNA sequencing

Sensing at the Surface of Graphene Field‐Effect Transistors

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