Detectable Anti-Dengue Virus Igm Antibodies Among Healthy Individuals in Ogbomoso, Oyo State, Nigeria

Abstract

Dengue fever is a zoonosis maintained in nature by mosquitoes transmitting virus between non-human primate species, most of which develop clinically in apparent infection. It has been found to be endemic in Africa and beyond. A survey for Dengue virus IgM antibody was carried out in Ogbomoso (urban and rural areas) using Enzyme Linked Immunosorbent Assay (WKEA Med Supplies Corp, Dengue fever virus ELISA Kit (China),) to determine the seroprevalence and true incidence of dengue virus in Ogbomoso. A total of 186 apparently healthy individuals were recruited into the study. The sera of 93 subjects who consented to participate were collected. The mean age of the subjects tested was 37.6±0.67. Anti-Dengue virus IgM antibodies were found in 16/93, (17.2%). The highest prevalence of anti-Dengue 28.6% was found in persons whose ages were between 0-15 years, males (18.9%), civil servants (26.3%) and urban dwellers (21.3%). The findings from this study show that there is primary infection of this virus in Ogbomoso and suggest the need for preventive and control measures against dengue fever virus.

Prevalence of Dengue Virus Infection Among Febrile Outpatients Attending University of Maiduguri Teaching Hospital in Borno State, Nigeria

“…However, this observation contrasts that of Oladipo et al [18] who reported a higher prevalence in males than females. The differences in prevalence rates between the genders could be attributed to differences in sample size in the different studies.…”

“…The higher prevalence of dengue NS1 in males than females reported in this study is in disagreement with Dawurung et al [16] who reported higher prevalence of dengue NS1 in females than males in Jos, Nigeria.The age bracket 1-14 years recorded the highest prevalence rate (76.9%) for DENV IgM antibodies. This result, although higher than the 28.6% reported by Oladipo et al [18] and 35% by Garg et al [24], tallies with their observation on the age bracket that recorded the highest prevalence rates. The findings of this study also agrees with the reports of Shah et al [25] and Anderson et al [26]who also observed a higher prevalence of dengue virus among age group 1-15 years.…”

“…al. [18] in a study conducted in Ogbomosho, Nigeria, 30.8% reported by Faneye et al [19] and the 0.6% reported by Baba et al [20] all in Nigeria. However, this result is lower than the 51.9% observed by Bello et al [21].…”

Seroprevalence of IgM Antibodies to Dengue Fever Virus among Patients Presenting with Symptoms of Fever in Some Hospitals in Kaduna State, Nigeria

“…A prevalence of 30.8% was reported by Faneye et al [12], 17.7% by Srinivas et al [13], 17.2% in Ogbomoso by Oladipo etbal. [14] and 0.6% reported by Baba et al [15]. The results of these studies emphasize the importance of surveying dengue fever virus.…”

“…The 51.9% prevalence obtained in this study is higher than the report of previous studies in Nigeria. A prevalence of 30.8% was reported by Faneye et al [12], 17.7% by Srinivas et al [13], 17.2% in Ogbomoso by Oladipo et al [14] and 0.6% reported by Baba et al [15].…”