Detailed review on phytosomal formulation attenuating new pharmacological therapies

Dwivedi, Jyotsana; Sachan, Pranjal; Wal, Pranay; Dwivedi, Sumeet; Sharma, Mukesh Chandra; Rao, Surada Prakash

doi:10.1007/s13596-023-00712-3

Cited by 3 publications

(1 citation statement)

References 160 publications

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“…In mice with dementia caused by conotoxin, M. oleifera leaves also operate as a neuroprotective and augment cognitive function (Dwivedi et al, 2023a). In response to the administration of leaf extract, lower levels of brain lipid peroxidation and higher levels of superoxide dismutase and catalase were seen.…”

Section: Potential For Neuroprotectionmentioning

confidence: 99%

Moringa oleifera (Moringaceae) an in-depth review of its nutritional classification and therapeutic application

Sachan,

Goswami,

Goswami

2024

RIP

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The nutritional and various medical benefits of Moringa oleifera have been recognized for ages in a variety of habitats and introduced areas. A common tree in many tropical and subtropical nations is the M. oleifera. It belongs to the family Moringaceae. Various plant parts, including the leaves, roots, seeds, fruit, bark, flowers, and immature pods, it is used as analgesic, antioxidant, antibacterial, anticancer, antipyretic, anti-inflammatory, antiulcer, antispasmodic, diuretic, and antihypertensive properties both humans and animals can benefit from eating Moringa leaves. M. oleifera is a plant whose many components are used to make traditional human meals. Protein, vitamins A, B, and C, as well as minerals, are all abundant in Moringa leaves. Up to 25% of M. oleifera leaf is made up of crude protein. Various M. oleifera plant components, including leaves, fruits, immature pods, and flowers, are grown in many tropical and subtropical nations.

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Section: Potential For Neuroprotectionmentioning

confidence: 99%

Moringa oleifera (Moringaceae) an in-depth review of its nutritional classification and therapeutic application

Sachan,

Goswami,

Goswami

2024

RIP

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Nano-phytosome loaded Retama raetam extract/colistin: antibacterial, antioxidant activities and in vivo lipopolysaccharide-induced-neurotoxicity inhibition

Elsabrouty,

Elwakil,

Salam

et al. 2024

Braz J Microbiol

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Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets

Rahman,

Rakib-Uz-Zaman,

Chakraborti

et al. 2024

Cells

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Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance and cytoplasmic quality control, in addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes of cancer deaths globally and shows resistance to several anticancer drugs. Despite the rising incidence and poor prognosis of malignant HCC, the underlying molecular mechanisms driving this aggressive cancer remain unclear. Several natural compounds, such as phytochemicals of dietary and non-dietary origin, affect hepatocarcinogenesis signaling pathways in vitro and in vivo, which may help prevent and treat HCC cells. Current HCC cells treatments include chemotherapy, radiation, and surgery. However, these standard therapies have substantial side effects, and combination therapy enhances side effects for an acceptable therapeutic benefit. Therefore, there is a need to develop treatment strategies for HCC cells that are more efficacious and have fewer adverse effects. Multiple genetic and epigenetic factors are responsible for the HCC cells to become resistant to standard treatment. Autophagy contributes to maintain cellular homeostasis, which activates autophagy for biosynthesis and mitochondrial regulation and recycling. Therefore, modifying autophagic signaling would present a promising opportunity to identify novel therapies to treat HCC cells resistant to current standard treatments. This comprehensive review illustrates how natural compounds demonstrate their anti-hepatocellular carcinoma function through autophagy.

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Detailed review on phytosomal formulation attenuating new pharmacological therapies

Cited by 3 publications

References 160 publications

Moringa oleifera (Moringaceae) an in-depth review of its nutritional classification and therapeutic application

Moringa oleifera (Moringaceae) an in-depth review of its nutritional classification and therapeutic application

Nano-phytosome loaded Retama raetam extract/colistin: antibacterial, antioxidant activities and in vivo lipopolysaccharide-induced-neurotoxicity inhibition

Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets

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