Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers

Abstract

While numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of the self-assembled surfactants is the critical micelle concentration (cmc), which quantifies the tendency to associate, and provides the Gibbs energy of micellization. Several techniques are known for determining the cmc, but the isothermal titration calorimetry (ITC) can be used to measure both cmc and enthalpy change (ΔmicH) accompanying micelle formation. Outcomes of our calorimetric investigations were evaluated using a self-developed routine for handling ITC data and the thermodynamic parameters of mixed micelle formation were obtained from the nonlinear modelling of temperature- and composition- dependent enthalpograms. In the investigated temperature and micelle mole fractions interval, we observed some intervals where the cmc is lower than the ideal mixing model predicted value. These equimolar binary surfactant mixtures showed higher solubilization ability for poorly water-soluble model drugs than their individual compounds. Thus, the rapid and fairly accurate calorimetric analysis of mixed micelles can lead to the successful design of a nanoscale drug carrier.

Binary Mixed Micelles of Hexadecyltrimethylammonium Bromide–Sodium Deoxycholate and Dodecyltrimethylammonium Bromide–Sodium Deoxycholate: Thermodynamic Stabilization and Mixed Micelle Solubilization Capacity of Daidzein (Isoflavonoid)

“…The application of micellar systems (monocomponent and multicomponent) in pharmaceutical and food formulations is largely based on the micellar solubilization of poorly soluble (hydrophobic) particles in water. − If poorly soluble particles do not have polar groups or have an insufficient number of polar groups, they are incorporated into the hydrophobic core of the micelle (in contrast, if they have sufficient polar groups, they are located near the polar groups of surfactants with which they build hydrogen, dipole–dipole, and ion–dipole interactions, depending on whether the surfactants are ionic or nonionic). − …”

Investigation of the Effect of Dispersion Medium Parameters on the Aggregative Stability of Selenium Nanoparticles Stabilized with Catamine AB

“…They have been successfully used to stabilize various nanoscale materials, for example, Se NPs, silica nanospheres, and nanoscale ZnO [ 1 , 2 , 3 , 4 ]. They are one of the most effective stabilizers due to their adsorption ability on the surface of nanoparticles [ 5 , 6 , 7 , 8 ]. Scientists have found that cetyltrimethylammonium bromide (CTAB) can be adsorbed onto silver nanoparticles by strong chemisorption in an aqueous solution, which is accompanied by the stabilization of nanoparticles [ 9 ].…”