Detailed anatomic segmentations of a fetal brain diffusion tensor imaging atlas between 23 and 30 weeks of gestation

Calixto, Camilo A.; Machado‐Rivas, Fedel; Karimi, Davood; Cortes-Albornoz, Maria Camila; Acosta‐Buitrago, Lina M.; Gallo-Bernal, Sebastián; Afacan, Onur; Warfield, Simon K.; Gholipour, Ali; Jaimes, Camilo

doi:10.1002/hbm.26160

Cited by 14 publications

(10 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calixto et al. [42] developed a system of neuroanatomical labels for a spatiotemporal atlas of fetal brain DTI from 23 to 30 weeks gestational age using a tensor‐to‐tensor registration algorithm; they also compared automated and manual segmentations (Figure 4). Song et al.…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

“…This technique may lead to development of noninvasive quantitative MRI biomarkers that might assist with diagnosis and characterization of pregnancies at high risk for congenital or developmental brain anomalies. Calixto et al [42] developed a system of neuroanatomical labels for a spatiotemporal atlas of fetal brain DTI from 23 to 30 weeks gestational age using a tensor-to-tensor registration algorithm; they also compared automated and manual segmentations (Figure 4). Song et al [43] compared prenatal (gestational age 23-35 weeks) and postnatal (age 1 day to 2 years) DTI in the corpus callosum and corticospinal tracts of 12 subjects using deterministic tractography.…”

Section: F I G U R Ementioning

confidence: 99%

See 1 more Smart Citation

Advanced neuroimaging in the fetal brain: An update on technical advances and clinical findings

Ren

Dong

2023

iRADIOLOGY

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is widely used to provide detailed information regarding fetal brain development in utero. Conventional T1-and T2weighted sequences provide anatomical details of the normal brain and demonstrate brain lesions. In addition to providing highly detailed qualitative assessments of fetal brain development, advanced MRI methods such as threedimensional high-resolution MRI, diffusion MRI, magnetic resonance spectroscopy, and functional MRI can provide quantitative morphologic assessments of tissue microstructure and functional activity. This review aims to describe normal fetal brain development and highlight current state-of-the-art MRI sequences for fetal neuroimaging. We focus on current clinical applications which can provide a better understanding of in utero impairments in fetal brain development.

show abstract

Section: Current Clinical Applicationsmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Advanced neuroimaging in the fetal brain: An update on technical advances and clinical findings

Ren

Dong

2023

iRADIOLOGY

View full text Add to dashboard Cite

show abstract

“…A few studies have developed dMRI atlases that map the spatio-temporal changes in diffusion tensor [37] and fiber orientation distribution [38,39]. These atlases have been used to perform various analyses and extract valuable new insights about fetal neurodevelopment [40][41][42].…”

Section: Introductionmentioning

confidence: 99%

A detailed spatio-temporal atlas of the white matter tracts for the fetal brain

Calixto,

Soldatelli,

Jaimes

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

This study presents the construction of a comprehensive spatiotemporal atlas detailing the development of white matter tracts in the fetal brain using diffusion magnetic resonance imaging (dMRI). Our research leverages data collected from fetal MRI scans conducted between 22 and 37 weeks of gestation, capturing the dynamic changes in the brain's microstructure during this critical period. The atlas includes 60 distinct white matter tracts, including commissural, projection, and association fibers. We employed advanced fetal dMRI processing techniques and tractography to map and characterize the developmental trajectories of these tracts. Our findings reveal that the development of these tracts is characterized by complex patterns of fractional anisotropy (FA) and mean diffusivity (MD), reflecting key neurodevelopmental processes such as axonal growth, involution of the radial-glial scaffolding, and synaptic pruning. This atlas can serve as a useful resource for neuroscience research and clinical practice, improving our understanding of the fetal brain and potentially aiding in the early diagnosis of neurodevelopmental disorders. By detailing the normal progression of white matter tract development, the atlas can be used as a benchmark for identifying deviations that may indicate neurological anomalies or predispositions to disorders.

show abstract

“…To understand the highly dynamic three-dimensional architecture and complex shape of the GE, a novel, more reliable and 31,32 precise method is necessary, which can be provided by the application of super-resolution MRI. Despite the application of advanced diffusion tensor imaging (DTI) in postmortem MRI 10,11 , the precise developmental dynamics of the GE in relation to the developing cortical plate and total brain growth remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the application of advanced diffusion tensor imaging (DTI) in postmortem MRI 10,11 , the precise developmental dynamics of the GE in relation to the developing cortical plate and total brain growth remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Ganglionic eminence: volumetric assessment of transient brain structure utilizing fetal magnetic resonance imaging

Stuempflen

Taymourtash

Kienast

et al. 2023

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

ObjectiveTo provide initial quantitative magnetic resonance (MR) super‐resolution‐based three‐dimensional volumetric reference data on the growth dynamics of the ganglionic eminence (GE) in relation to cortical (CV) and total fetal brain volumes (TBV).MethodsThis retrospective study investigated 120 fetuses (undergoing 127 MRI scans, mean gestational age 27.3 weeks, SD 4.8 weeks) without structural CNS anomalies or other confounding comorbidities. Super‐resolution reconstructions of 1.5 and 3 T T2‐weighted images were generated. In addition to semi‐automated segmentation of the TBV and the CV, manual segmentation of the ganglionic eminence was performed. CV, TBV, and GE were quantified and three‐dimensional reconstructions were generated to visualize the developmental dynamics of the GE.ResultsIn the observed gestational ages, the GE volumes ranged from 74.88 to 808.75 mm3 and a maximum was detected at 21 gestational weeks followed by a linear decrease (R2 = 0.559) throughout the second and trimester. A drastic reduction of GE relative to CV and TBV in the late second trimester was observed with an exponential reduction (R2 = 0.936 and 0.924, respectively). Three‐dimensional renderings visualized a continuous change in the shape and size of the GE throughout the second and third trimester.ConclusionsEven small compartments of the fetal brain, which are inaccessible by standardized two‐dimensional measurements, can be precisely determined by super‐resolution processed fetal MRI. The inverse growth dynamics of the GE compared to TBV and CV documents the transitory nature and physiological involution of this (patho‐)physiologically important brain structure. The normal development and involution of the ganglionic eminence is mandatory for normal cortical development. Pathological changes of this transient organ will precede impairment of cortical structures and thus may allow an earlier diagnosis thereof.This article is protected by copyright. All rights reserved.

show abstract

Detailed anatomic segmentations of a fetal brain diffusion tensor imaging atlas between 23 and 30 weeks of gestation

Cited by 14 publications

References 44 publications

Advanced neuroimaging in the fetal brain: An update on technical advances and clinical findings

Advanced neuroimaging in the fetal brain: An update on technical advances and clinical findings

A detailed spatio-temporal atlas of the white matter tracts for the fetal brain

Ganglionic eminence: volumetric assessment of transient brain structure utilizing fetal magnetic resonance imaging

Contact Info

Product

Resources

About