Advanced neuroimaging in the fetal brain: An update on technical advances and clinical findings

Ren, Jing-Ya; Dong, Shumei

doi:10.1002/ird3.19

Cited by 1 publication

(1 citation statement)

References 63 publications

(73 reference statements)

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“…Molecular imaging is a new generation of imaging modality that employs contrast agents to enable in vivo qualitative and quantitative analysis and detection of physiological processes at the molecular level, thus providing information unavailable through traditional imaging modalities [1], such as optical imaging [2][3][4], ultrasound imaging [5,6], magnetic resonance imaging (MRI) [7][8][9], single-photon emission computed tomography (SPECT) [10], and positron emission tomography (PET) [11][12][13]. Molecular optical imaging based on phenomena such as fluorescence, Raman scattering, chemiluminescence, and bioluminescence is widely used for disease diagnosis, drug development, and pathological analysis owing to its high sensitivity, high contrast ratio, high resolution, and high imaging speed [14,15].…”

Section: Introductionmentioning

confidence: 99%

Harnessing the power of molecular imaging for drug discovery and development

Luo,

Tan,

Zhao

et al. 2023

iRADIOLOGY

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Non‐invasive, real‐time, dynamic, and quantitative molecular imaging has been developed to facilitate disease diagnosis, drug development, and pathological analysis at the molecular level. Qualitative and quantitative analysis and imaging of physiological processes at the molecular level can be achieved with advanced molecular imaging by employing imaging contrast agents in combination with traditional imaging modalities, such as optical imaging, ultrasound imaging, magnetic resonance imaging, single‐photon emission computed tomography, and positron emission tomography. With the aid of molecular imaging, absorption, distribution, metabolism, excretion, and other processes of drugs in various animals can be monitored quantitatively, and in vivo pharmacokinetics and pharmacodynamics can be simulated before clinical trials, which significantly shorten the period for drug development and reduce the number of animals participating in various tests. Here, the role of molecular imaging in drug target validation, drug screening, drug sensitivity analysis, pharmacokinetics research, drug efficacy evaluation, and other processes of chemical and biological drug research and development is summarized. Molecular imaging has become a powerful and effective tool in the research and development of various drugs for the treatment of a variety of diseases. Advanced molecular imaging can provide important support for disease and drug research, which will accelerate drug discovery and development.

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