Detailed analysis of the behavior of Lister and Wistar rats in anxiety, object recognition and object location tasks

Ennaceur, Abdelkader; Michalíková, S.; Bradford, Andrea; Ahmed, Samrah

doi:10.1016/j.bbr.2004.11.006

Cited by 178 publications

(113 citation statements)

References 64 publications

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“…The mice failed to discriminate between the objects in the familiar and novel location 24 h later, precluding the assessment of SD effects. This incapacity is consistent with data showing that C57BL/6 mice and several rat strains (DA, Sprague-Dawley and Lister) tested in the object location task successfully discriminated between the familiar and novel object location after a delay interval of up to 6 h, while others (DBA/2 mice and Wistar rats) did not (Dix & Aggleton, 1999;Ennaceur, Michalikova, Bradford, & Ahmed, 2005;Hotte, Naudon, & Jay, 2005;Lee, Hunsaker, & Kesner, 2005;Roullet, Mele, & Ammassari-Teule, 1997). This failure in discrimination between the familiar and novel location of the objects can be related to either impaired memory for the object per se or inability to use spatial information after the relatively long delay of 24 h.…”

Section: Discussionsupporting

confidence: 89%

Sleep deprivation impairs object recognition in mice

Palchykova

Winsky‐Sommerer

Meerlo

et al. 2006

Neurobiology of Learning and Memory

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Section: Discussionsupporting

confidence: 89%

Sleep deprivation impairs object recognition in mice

Palchykova

Winsky‐Sommerer

Meerlo

et al. 2006

Neurobiology of Learning and Memory

160

123

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“…However, the OR and OP tasks do not use a training paradigm, and as such traditional 'learning' does not occur (Ennaceur et al, 2005), which should eliminate possible confounds of behavioral experience between the two cohorts. As such, we believe that the differences in BDNF found between NP and MP females in the CA1 are in greater part due to parity, and not behavior experience.…”

Section: Multiparity Significantly Elevated Bdnf Concentration In Ca1mentioning

confidence: 99%

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)

Macbeth

Scharfman

MacLusky

et al. 2008

Hormones and Behavior

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Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess possible enduring effects of multiparity at least 3 months after last litter was weaned. MP females performed significantly better than NP females on the non-spatial memory task, object recognition, and the spatial memory task, object placement. Anxiety as measured on the elevated plus maze did not differ between groups. Monoaminergic activity and levels were measured in prefrontal cortex, CA1 hippocampus, CA3 hippocampus, and olfactory bulb (OB). NP and MP females differed in monoamine concentrations in the OB only, with MP females having significantly greater concentrations of dopamine and metabolite DOPAC, norepinephrine and metabolite MHPG, and the serotonin metabolite 5-HIAA, as compared to NP females. These results indicate a long-term change in OB neurochemistry as a result of multiparity. Brain-derived neurotrophic factor (BDNF) was also measured in hippocampus (CA1, CA3, dentate gyrus), and septum. MP females had higher BDNF levels in both CA1 and septum; as these regions are implicated in memory performance, elevated BDNF may underlie the observed memory task differences. Thus, MP females (experiencing multiple bouts of pregnancy, birth, and pup rearing during the first year of life) displayed enhanced memory task performance, but equal anxiety responses, as compared to NP females. These results are consistent with previous studies showing long-term changes in behavioral function in MP, as compared to NP, rats, and suggest that alterations in monoamines and a neurotrophin, BDNF, may contribute to the observed behavioral changes.

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“…More specifically, we tested: (1) general anxiety behavior in an Elevated Plus Maze (EPM, Rodgers and Dalvi, 1997); (2) reward-based decision making in a rodent version of the Iowa Gambling Task (rIGT; Van den Bos et al, 2014) (3) non-stressful contextual learning in an object recognition task (ORT, Bevins and Besheer, 2006) and an object-in-location task (OLT, adapted from Ennaceur et al, 2005). Hippocampal structural measures included dentate gyrus (DG) volume, proliferation and neurogenesis that can be altered by (early life) stress and are involved in aspects of cognition (Lucassen et al, , 2013Oomen et al, 2011Oomen et al, , 2014.…”

Section: Introductionmentioning

confidence: 99%

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

et al. 2017

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Effects of early-life stress on cognitive function and hippocampal structure in female rodents Loi, M.; Mossink, J.C.L.; Meerhoff, G.F.; den Blaauwen, J.L.; Lucassen, P.J.; Joëls, M. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract-We tested the effect of early-life stress (ELS) -24 h maternal deprivation (MD) at postnatal day (PND) 3 -on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window , in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.

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Detailed analysis of the behavior of Lister and Wistar rats in anxiety, object recognition and object location tasks

Cited by 178 publications

References 64 publications

Sleep deprivation impairs object recognition in mice

Sleep deprivation impairs object recognition in mice

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

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