Desulfonylation reactions: Recent developments

Vinyl Sulfone: A Multi-Purpose Function in Proteomics

“…2). In all cases, the resulting 1,4-addition products contain either the sulfonyl moiety which can undergo subsequent functional group transformations or can be easily removed (by means of Mg or Hg/Na) making these compounds a perfect choice to afford easily naked alkyls (Nájera & Yus, 1999). Heteroatomic nucleophiles differ in the kinetic of their conjugate addition to Michael acceptors including vinyl sulfones, fact that is relied to their nucleophilicity.…”

Studies on stereoselective approaches to β-carboline derivatives

“…Diastereomers 4a and 4b were separated by chromatography, but the configuration of C-1 could not been elucidated. Even after trying several methods described in the literature [7] [sodium amalgam, magnesium/methanol, zinc/acetic acid, sodium metal in ethanol, sodium borohydride with tetrakis(triphenylphosphine) palladium(0)], we did not succeed in removing the camphor sulfonyl auxiliary. Moreover, in the presence of NICRA catalyst [8] (prepared from nickel diacetate, sodium hydride in tert.-amyl alcohol), only traces of 2 could be detected by thin-layer chromatography.…”

Synthesis of (E)-1,4-diaryl-2-butene-1,4-diones

“…[1][2][3][4][5][6] Notably, a number of examples have been reported for versatile functional group transformations. The diversified skeletons include (1) acyclic diketones, 7 α-methenyl ketones, [8][9] and styrylsulfones, 15 (2) monocyclic sulfones, 10 cyclopropanes, 16 triazoles, 11 pyrazoles, [12][13] dihydrofurans, 14,19 tetrahydrofurans, 17 tetrahydropyrans, 18 pyrroles, 20 furans, [21][22] benzenes, 23 and pyridazines, 24 (3) bicyclic benzosuberans, 25 tetralins, 26 and naphthalenes, 27 (4) tricyclic phenanthrenes, 28 and (5) tetracyclic phenanthrofurans.…”