Destabilization of CARP mRNAs by aloe‐emodin contributes to caspase‐8‐mediated p53‐independent apoptosis of human carcinoma cells

Lin, Meng Liang; Lu, Yao; Su, Hong; Lin, Hsin Ting; Lee, Chuan Chun; Kang, Shang En; Lai, Tan Chen; Chung, Jing Gung; Chen, Shih Shun

doi:10.1002/jcb.23031

Cited by 35 publications

(25 citation statements)

References 40 publications

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“…Previous studies proved that activations of caspase-9 and caspase-3 lead to apoptosis in FaDu cells [39,40]. Here, deltonin treatment altered expression levels of caspase-3, caspase-8 and caspase-9 in concentration-and time-dependent manners and also increased the expression of Bax in concentration dependent manner ( Figure 4A and 4B).…”

Section: Discussionsupporting

confidence: 60%

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Xie¹,

Fan²,

Jiang³

et al. 2015

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For decades, despite the advancement of medical science, the prognosis of head and neck squamous cell carcinoma (HNSCC), has not improved. Deltonin is one of the major active components of Dioscorea Zingiberensis Wright that has been used for anthrax, rheumatic heart disease, rheumatoid arthritis etc. By employing HNSCC FaDu cell and normal human epidermal keratinocyte, we investigate deltonin efficacy and associated mechanism in both cell culture and nude mice xenografts. Deltonin treatment selectively prevents proliferation of FaDu cells by cell-cycle arrest and induction of apoptosis, via activating checkpoint kinase Chk1and Chk2 as well as caspases 8, 9 and 3. Meanwhile, we found that treatment with deltonin induced autophagy, which played a protective role against deltonin-induced apoptosis. Further studies revealed that deltonin activated autophagy by Akt-mTOR signaling. Additionally, xenograft model showed that administration of deltonin significantly inhibited tumor growth and prolonged survival of tumor bearing mice. Our studies suggested that deltonin might be a potential chemotherapeutic agent against HNSCC, which might contribute to clinical application and pharmacological study of deltonin in future anti-cancer research.

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Section: Discussionsupporting

confidence: 60%

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Xie¹,

Fan²,

Jiang³

et al. 2015

neo

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“…The stability of the mRNAs encoding caspase-8 and -10-associated RING proteins (CARPs) 1 and 2 was affected by aloe emodin, whereas CARP1 or 2 overexpression inhibited caspase-8 activation and apoptosis induced by aloe emodin. Collectively, the present data indicate aloe emodin induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner [39] . To evaluate the potential anticancer properties and modulatory effect of selected Aloe vera three active principles on antioxidant enzyme activities; aloesin, aloe emodin and barbaloin were extracted from Aloe vera leaves by supercritical fluid extraction and subsequently purified by high performance liquid chromatography.…”

Section: +supporting

confidence: 52%

Putative Prophylaxes of Aloe Vera for Age-Related Diseases

Yagi

2015

Journal of Gastroenterology and Hepatology Research

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The aim of the present review is focused on putative prophylaxes of Aloe vera for age-related diseases, and its check items are generally known traditional and specific diseases followed by In vitro, animal, and preliminary clinical studies: (1) prevention of cancer and alleviation of progeria; (2) prevention of cardiovascular and cerebro-vascular disorders, and inhibition of acetylcholinesterase; (3) preliminary clinical study of an aloemannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease; (4) prevention of photo-aging and polycystic ovarian syndrome; (5) stimulation of periodontal fibroblasts, bone formation, and healing of pain and nephro-toxicity; and (6) anti-inflammation and immuno-response, excluding diabetic and hepatic disorders.

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“…Concerning the involvement of apoptotic initiators, both caspase-8 and caspase-9 were increasingly reported in earlier papers [16,18,19] . The sole apoptotic executioner known so far to be involved in AE-induced cell death is caspase-3 [7,20] .…”

Section: Discussionmentioning

confidence: 99%

Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells

et al. 2012

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Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6.

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Destabilization of CARP mRNAs by aloe‐emodin contributes to caspase‐8‐mediated p53‐independent apoptosis of human carcinoma cells

Cited by 35 publications

References 40 publications

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Putative Prophylaxes of Aloe Vera for Age-Related Diseases

Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells

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