Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes

Rachmawati, Heni; Rahma, Annisa; Shaal, Loaye Al; Müller, Rainer H.; Keck, Cornelia M.

doi:10.3390/scipharm84040685

Cited by 29 publications

(16 citation statements)

References 23 publications

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“…BM was expected to comminute the remaining larger particles that were left behind from the HPH, thus leading to small sized PlantCrystals with homogenous particle size. The further decrease in size was expected to increase the physical stability of the PlantCrystals [ 11 ] and to further increase the amount of plant components extracted. Consequently, to prove this theory, the third part of the study was conducted by milling plant material with HPH, BM and with a combination of HPH and BM, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, it is an industrially feasible and environmentally friendly process that avoids the use of organic solvents. The equipment required is low-cost, freely available and meanwhile established in many laboratories world-wide [ 10 , 11 , 12 , 13 , 14 ]. The feasibility of the PlantCrystal technology was proven in previous studies, where PlantCrystals were shown to increase the antimicrobial and antifungal activity of various plant materials [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

et al. 2020

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PlantCrystals are obtained by milling plant material to sizes <10 µm. Due to the disruption of the plant cells, active compounds are easily released, rendering the PlantCrystal technology an effective and low-cost process for the production of environmentally friendly plant extracts. The extracts can be used to produce phytomedicines, nutritional supplements or cosmetic products. Previous studies could already demonstrate the use of PlantCrystals to improve the antimicrobial or antifungal activity of different plants. This study investigated whether PlantCrystal technology is suitable to produce plant derived formulations with high antioxidant capacity. The study also aimed to identify the most suitable production methods for this. Methods: Various plant materials and parts of plants, i.e., seeds, leaves and flowers, and different methods were employed for the production. PlantCrystals were characterized regarding size, physical stability and antioxidant capacity (AOC). Results: PlantCrystals with particles <1 µm were produced from the different plant materials. Both production methods, i.e., high-pressure homogenization, bead milling or the combination of both were suitable to obtain PlantCrystals. Nano milling of the plant material greatly affected their AOC and resulted in formulations with distinctly higher AOC when compared to classical extracts. Conclusions: Rendering plant material into small sized particles is highly effective to obtain plant extracts with high biological efficacy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

et al. 2020

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“…Aqueous solutions of PVA of 1%, 3%, and 5% were used for the preparation of PNP in both techniques. The amount of surfactant plays an essential role in the emulsication-solvent evaporation process, by the protection of the droplets containing the PLGA against coalescence 65,66. Fig.…”

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confidence: 99%

PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters

et al. 2020

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“…When neutral polymers are used, a shift in the shear plane away from the surface was observed, resulting in lower values for zeta potential. 45 The polynomial regression equation generated for the coded factors is shown below…”

Section: Effect Of Independent Variables On Zeta Potentialmentioning

confidence: 99%

“…The effect of the parameters is clearly observed in the 3D plots shown in Figure 1A-F. As per the reports, an increase in the PVA concentration increases the particle size due to the increased viscosity of the dispersion medium, resulting in decreased attrition between balls and particles and also leading to greater amount of coating on the particle surface. [43][44][45][46] The increase in the amount of ACF was found to increase the particle size. This could be possibly due to the increased amount of drug in the dispersed phase that Figure 1 Three-dimensional plots showing the effect of independent variables on particle size.…”

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confidence: 99%

A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies

Narayan¹,

Pednekar²,

Bhuyan³

et al. 2017

IJN

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The aim of the present work was to tackle the solubility issue of a biopharmaceutics classification system (BCS)-II drug, aceclofenac. Although a number of attempts to increase the aqueous solubility have been made, none of the methods were taken up for scale-up. Hence size reduction technique by a top-down approach using wet milling process was utilized to improve the solubility and, consequently, the dissolution velocity of aceclofenac. The quality of the final product was ensured by Quality by Design approach wherein the effects of critical material attributes and critical process parameters were assessed on the critical quality attributes (CQAs) of nanocrystals. Box–Behnken design was applied to evaluate these effects on critical quality attributes. The optimized nanocrystals had a particle size of 484.7±54.12 nm with a polydispersity index (PDI) of 0.108±0.009. The solid state characterization of the formulation revealed that the crystalline nature of the drug was slightly reduced after the milling process. With the reduced particle size, the solubility of the nanocrystals was found to increase in both water and 0.1 N HCl when compared with that of unmilled pure aceclofenac. These results were further supported by in vitro release studies of nanocrystals where an appreciable dissolution velocity with 100.07%±2.38% release was observed for aceclofenac nanocrystals compared with 47.66%±4.53% release for pure unmilled aceclofenac at the end of 2 h. The in vivo pharmacokinetic data generated showed a statistically significant increase in the C max for aceclofenac nanocrystals of 3.75±0.28 µg/mL (for pure unmilled aceclofenac C max was 1.96±0.17 µg/mL). The results obtained indicated that the developed nanocrystals of aceclofenac were successful in improving the solubility, thus the absorption and bioavailability of the drug. Hence, it may be a viable and cost-effective alternative to the current therapy.

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Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes

Cited by 29 publications

References 23 publications

PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters

A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies

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