Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid

Vijayan, Veena; Paul, Ajish; Babu, Kennedy; Madhan, Balasubramanian

doi:10.4103/0972-124x.182602

Cited by 13 publications

(18 citation statements)

References 5 publications

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“…Orthodontic treatment may initiate oral clinical manifestations, such as labial desquamation [15], gingival enlargement [16,17,18], multiform erythema [19] and gingivitis [20].…”

Section: Resultsmentioning

confidence: 99%

Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

Simon¹,

Bratu²,

Motoc³

et al. 2020

Rev. Chim.

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Our study started from the hypothesis that the gingival volume growth associated with fixed orthodontic treatment appeared during the use of leveling and aligning archwires, without any inflammatory signs, as a result of the mechanical stress and periodontal remodeling during the orthodontic dental movement.We selected and included in the study 35 patients (13 females and 12 males) between 12 and 38 years of age, all suffering from gingival overgrowth, diagnosed during the active treatment with fixed orthodontic appliances (braces). For each patient, two tissue samples were taken: one in the early stages of the lesion, coinciding with the use of leveling and aligning archwires and another in the late stages of the lesion, coinciding with the use of finishing archwires. The samples were taken from the same site in the oral cavity. Out of 35 gingival biopsies taken from patients, 8 cases showed no significant changes in the gingiva, while in the remaining 27 cases, significant changes were found after the histopathological exam.Out of 27 gingival biopsies, 16 cases presented a significantly greater number of T cells. In addition, a greater number of B cells were observed in the granulation tissues than in the gingiva. The relative number of B cells (CD20), T cells and dendritic cells (CD8) has been expressed, both in the early and the late stages of the gingival lesions. Our results revealed that the proportion of T lymphocytes and dendritic cells was greater in the early stages rather than at the late stages. The B cells showed a higher count in the late stages.

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“…Orthodontic treatment may initiate oral clinical manifestations, such as labial desquamation [15], gingival enlargement [16,17,18], multiform erythema [19] and gingivitis [20].…”

Section: Resultsmentioning

confidence: 99%

Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

Simon¹,

Bratu²,

Motoc³

et al. 2020

Rev. Chim.

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“…The oral cavity's lesions are seen in almost all reported cases and in 48% of patients, oral cavity is the first site of involvement. When there is oral lesion, gingival involvement is seen in 100% of cases (1,14).…”

Section: Discussionmentioning

confidence: 99%

“…The first lesion of MMP occurs once autoantibodies, directed against proteins within the basement membrane zone, acting with complement (C3), cause a subepithelial split and resultant vesicle formation. Antibodies against basement membrane antigens are known in cases of MMP (1)(2)(3). Lesions of MMP could involve any mucosal surface, however, the oral mucosa is involved in more than 80% of cases, seldom with scarring.…”

Section: Introductionmentioning

confidence: 99%

A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report

Koopaie

2018

J Arch Mil Med

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Desquamative gingivitis (DG) is a descriptive term, indicating inflamed and peeling gingiva. It is characterized by sloughing of the gingival epithelium as a result of formation and rupture of the vesicle. Consequently, the gingiva appears erythematous and often edematous. Desquamative gingivitis may represent an oral clinical manifestation of various systemic mucocutaneous diseases. This case report is on a 42-year-old female with chief complaint of burning sensation in the anterior maxillary gingiva. The patient did not have any other lesion at other sites of the oral cavity. The patient had been affected by asthma and her medications were salbutamol spray and tab cetirizine. Clinically, anterior gingiva appeared as the presentation of desquamative gingivitis. Therefore, an incisional biopsy of the affected area for histopathologic assessment and an incisional biopsy of clinically normal-appearing gingiva for direct immunofluorescence (DIF) study were performed. The histopathologic report was herpes simplex infection. However, this report was incompatible with the clinical view and the patient history. Therefore, a second biopsy was performed. The second histopathologic report was compatible with MMP. The treatment plan was local corticosteroid with follow-up. At the one-month examination visit, a significant improvement was observed in the clinical view of the gums.

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“…This is because 90 percent of patients diagnosed with MMP often show signs of gingival involvement. However, this alone should not be a finite diagnosis without the additional biopsy results, as there is a diverse amount of autoimmune diseases that share this characteristic as well [5].…”

Section: Prevalence Clinical Presentations and Severity Levelsmentioning

confidence: 99%

“…The root cicatrix, which is used to form the word Cicatricial, comes from Latin origins meaning "to scar". The presence of scars related to CP, were diagnosed with the inclusion of scar tissue as a baseline identifier in commonalities and contrasts in the variety of cases [5]. Today, MMP is most commonly located in the oral mucosa, but can also be found in the conjunctiva, hypopharyngeal mucosae, inner nostril lining, sinus cavity, esophagus, larynx, and genital mucous membranes [6].…”

Section: Introductionmentioning

confidence: 99%

Mucous membrane pemphigoid: A wide-ranging assessment of various cases and corresponding methods of diagnosis and treatment

Sivri¹,

Chandra²

2018

Med-Science

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Mucous Membrane Pemphigoid (MMP) is as an infrequent yet tenacious autoimmune blistering disease involving the mucosae of the oral cavity, as well as the conjunctiva, genitals, nasal cavity, pharynx and occasionally the skin. It is seen most commonly in older adults, although cases have been reported throughout early childhood. This review article will provide a thorough explanation of MMP by discussing common misdiagnosis scenarios, presenting rare case reports, and exploring recent treatment options in hopes of spreading awareness for furthering research on diagnosis techniques. The purpose this article is to bring light to the dental community, medical professionals and autoimmune disease researchers, the importance of an early and authentic diagnosis and corresponding methods of recent treatments.

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Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid

Cited by 13 publications

References 5 publications

Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report

Mucous membrane pemphigoid: A wide-ranging assessment of various cases and corresponding methods of diagnosis and treatment

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