1999
DOI: 10.1590/s0037-86821999000100007
|View full text |Cite
|
Sign up to set email alerts
|

Despopulação neuronal cardíaca em hamsters (Mesocricetus auratus) cronicamente infectados com o Trypanosoma cruzi

Abstract: The aim of this study was to obtain an experimental animal model of destruction of cardiac neurons in order to investigate the behavior of the cardiac nervous system of hamsters chronically infected with Trypanosoma cruzi. We counted the neuronal cells of the cardiac autonomic nervous plexus in hamsters inoculated with 35,000 blood forms of three different T. cruzi strains and killed 5, 8 and 10 months after infection. We showed for the first time severe neuronal destruction in an experimental animal model wit… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
9
2

Year Published

2000
2000
2017
2017

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 13 publications
(11 citation statements)
references
References 8 publications
0
9
2
Order By: Relevance
“…Diffuse damage to the autonomic nervous system, principally of the parasympathetic branch affecting the heart and digestive tract, is a remarkable pathological feature commonly present in variable degrees and extents in the acute and all chronic forms of human Chagas disease 11,13,15,[17][18][19] and the corresponding forms of experimental Trypanosoma cruzi infection in different animal models [20][21][22][23][24] . This is a fact recognised soon after the description of the disease at the beginning of the past century.…”
Section: Cardiac Autonomic Nervous System In Chagas Diseasementioning
confidence: 99%
See 3 more Smart Citations
“…Diffuse damage to the autonomic nervous system, principally of the parasympathetic branch affecting the heart and digestive tract, is a remarkable pathological feature commonly present in variable degrees and extents in the acute and all chronic forms of human Chagas disease 11,13,15,[17][18][19] and the corresponding forms of experimental Trypanosoma cruzi infection in different animal models [20][21][22][23][24] . This is a fact recognised soon after the description of the disease at the beginning of the past century.…”
Section: Cardiac Autonomic Nervous System In Chagas Diseasementioning
confidence: 99%
“…Many autonomic components, mainly related to functional modulation of the heart and digestive viscera, including central neural structures at different levels, peripheral extrinsic and intrinsic autonomic ganglia, afferent neurons from receptors, sympathetic and parasympathetic efferent neurons and the beta-adrenergic and muscarinic cholinergic neurotransmitter cellular receptors, may be injured exclusively or in combination, and this has been demonstrated both in human and experimental Chagas disease 11,13,15,18,[20][21][22][23][26][27][28][29] .…”
Section: Cardiac Autonomic Nervous System In Chagas Diseasementioning
confidence: 99%
See 2 more Smart Citations
“…The human and experimental indeterminate forms present less conspicuous lesions of cardiac intrinsic innervation, which are usually represented by discrete to moderate focal or zonal chronic neuroganglionitis (Lopes and Tafuri, 1983;Andrade, 1984;Oliveira, 1985;Chapadeiro et al, 1991). Cardiac autonomic damage has also been observed in acute and chronic experimental Trypanosoma cruzi infection in mice (Tafuri, 1970;Souza et al, 1996), dogs (Andrade, 1984;Machado et al, 1998), rats (Chapadeiro et al, 1991;Junqueira et al, 1992), and hamsters (Chapadeiro et al, 1999) among other animal models.…”
Section: Introductionmentioning
confidence: 99%