Desoxyephedrine—a review of the literature

Haley, Thomas J.

doi:10.1002/jps.3030360602

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…(For reviews see Ivy and KRASNO 1941;and HALEY 1947. The technique of registration prevalent in the 1930s and 1940s (when the early clinical studies on amphetamine and its congeners were made) allowed demonstration only of major aberrations in physiologic parameters induced by the drug.…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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Amphetamine and related central stimulant drugs are derivatives of ß-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general ßphenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itselfhas central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the ex-methyl group, much less affinity for MAO and therefore has a longer half-Iife.Most amphetamines have cardiovascular, psychomotor stimulant, hyperthermic, and anorexigenic actions. All of the structural features of amphetamine are important far its spectrum of pharmacologic activity. Any alteration may enhance, diminish, or attenuate one or several components in the actions of the parent drug. (1) Substitution of the phenyl ring, (2) alteration of the length of the side chain, (3) substitution on the primary nitrogen group, (4) substitution of the ex-and ß-carbon atoms, and (5) their absolute configuration have been studied and will be briefly discussed here. For a more thorough review on the subject the reader is referred to the papers by BIEL (1970), vANRossuM and SIMONS (1969) and VREE (1973. The effect of ring and side-chain substitution on distribution and elimination of the amphetamines has been discussed by BECKETT and BROOKES (1970). recently reviewed the biochemical pharmacology of the amphetamines. The metabolism and disposition of methylphenidate were reported by F ARAJ et al.

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Section: Cardiovascular Effectsmentioning

confidence: 99%

General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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“…No studies were found in the literature concerning the effects of chronic administration of d-amphetamine on activity. Data on the effects of cocaine are limited to an experiment in which high doses of the drug were mixed in the food of rats and 24 hour activity was tested in revolving drums for a period of seven days. Average daily drug intake for this period was estimated.…”

Section: B Methamphetamine In Contrast Tomentioning

confidence: 99%

“…The drugs which will be discussed are: dl-amphetamine, d-amphetamine, methamphetamine, cocaine, pipradrol, methylphenidate, phenmetrazine, and caffeine. The task of compiling this survey of the literature has been facilitated by a number of review articles, including those of ConnelI,1 Leake,35 and Weiss and Laties 82 on the amphetamines; Ivy and Goetzl, 30 Haley,24 and Utena 77 on methamphetamine; Molina 44 and Gutierrez-Noriega and Zapata-Ortiz 23 on cocaine; and Krueger and Mc-Grath" on pipradrol and methylphenidate. The Psychopharmacology abstracts were an invaluable aid in the literature search.…”

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confidence: 99%

Effects of chronic administration of the amphetamines and other stimulants on behavior

Kosman

Unna

1968

Clin Pharma and Therapeutics

108

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“…In dogs the pressor effect was only about ~/ K O O that of epinephrine. s N A RECENT review of the literature of desoxy-I ephedrine, Haley (1) pointed out that, although the dextro isomer had been extensively studied, little was known concerning the racemic form of the drug. Inasmuch as clinical usage of the racemate had recently commenced, it was thought that a pharmacological and toxicological study might reveal some definite information about the mode of action of the drug.…”

mentioning

confidence: 99%