Desorption electrospray ionisation mass spectrometry: A rapid screening tool for veterinary drug preparations and forensic samples from hormone crime investigations

Fit‐for‐purpose in veterinary drug residue analysis: Development and validation of an LC‐MS/MS method for the screening of thirty illicit drugs in bovine urine

“…Besides officially non‐compliant samples, the present method finds wide application in the criminal investigation of new illegal administration protocols, drug cocktails 25 and disrespect of suspension periods, namely all situations where the residue urine concentration is too low to be detected by immunochemical methods. This investigation activity highlights the most critical farms susceptible of intensified surveillance.…”

“…As a multi‐class screening method, further developments will be addressed to update and extend the target analyte list as much as possible, so as to include all drug families for which the national residue detection plan prescribes urinary analysis. Another expected upgrading is the reduction of the analysis time by the use of ultra‐HPLC 25, 26, in order to improve the sample throughput.…”

Development of Novel Drugs from Marine Surface Associated Microorganisms

“…For example, the recently developed Ultra High Performance Liquid Chromatography (UPLC) coupled to high resolution mass spectrometers (MS), as well as capillary probe nuclear magnetic resonance spectrometers have greatly assisted the process of natural product discovery from mass limited samples [130,144,145]. Likewise, the newly developed Desorption Electrospray Ionisation Mass Spectrometry (DESI-MS) technique allows for the rapid detection of the compounds requiring minimal effort to be spent on sample preparation [131,132]. These techniques may soon eliminate, or, by some estimates, have already eliminated the purification and chemical characterisation step as a major drawback in natural product discovery [146–150].…”

Desorption electrospray ionization-high resolution mass spectrometry for the screening of veterinary drugs in cross-contaminated feedstuffs

“…Nevertheless, only few papers described the use of ambient techniques for the analysis of veterinary drugs [32,33]. DESI-MS has been applied for a rapid screening of hormones and veterinary drugs in samples from forensic investigations using an ion trap (IT) mass analyzer, although authors indicated the difficulty to detect tetracyclines under the DESI-MS conditions used [34]. Moreover, DART-HRMS has been applied for the target analysis of coccidiostats in feed samples using an orbitrap mass analyzer demonstrating the feasibility of this ambient technique to quantify these analytes at the levels established by the EU legislation [32].…”